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    NAP1L2 nucleosome assembly protein 1 like 2 [ Homo sapiens (human) ]

    Gene ID: 4674, updated on 2-Nov-2024

    Summary

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    Official Symbol
    NAP1L2provided by HGNC
    Official Full Name
    nucleosome assembly protein 1 like 2provided by HGNC
    Primary source
    HGNC:HGNC:7638
    See related
    Ensembl:ENSG00000186462 MIM:300026; AllianceGenome:HGNC:7638
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BPX
    Summary
    The protein encoded by this intronless gene is a member of the nucleosome assembly protein (NAP) family. The encoded protein represents a class of tissue-specific factors that interact with chromatin to regulate neuronal cell proliferation. [provided by RefSeq, Jan 2011]
    Orthologs
    mouse all
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    Genomic context

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    See NAP1L2 in Genome Data Viewer
    Location:
    Xq13.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (73212299..73214851, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (71645741..71648293, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (72432135..72434687, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928380 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:72326297-72326910 Neighboring gene nucleosome assembly protein 1 like 6, pseudogene Neighboring gene TOMM20 pseudogene 4 Neighboring gene LRRFIP2 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SNPs in the CpG island of NAP1L2: a possible link between DNA methylation and neural tube defects? Rogner UC, et al. Am J Med Genet, 2002 Jul 1. PMID 12116227
    2. Control of neurulation by the nucleosome assembly protein-1-like 2. Rogner UC, et al. Nat Genet, 2000 Aug. PMID 10932189
    3. Cloning and characterization of a murine brain specific gene Bpx and its human homologue lying within the Xic candidate region. Rougeulle C, et al. Hum Mol Genet, 1996 Jan. PMID 8789438
    4. Identification of candidate genes in atopic dermatitis based on bioinformatic methods. Ding Y, et al. Int J Dermatol, 2016 Jul. PMID 26967585
    5. Interaction between nucleosome assembly protein 1-like family members. Attia M, et al. J Mol Biol, 2011 Apr 15. PMID 21333655

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC26243

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone acetyltransferase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of stem cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nucleosome assembly protein 1-like 2
    Names
    brain specific gene BPX
    brain-specific protein, X-linked

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013274.1 RefSeqGene

      Range
      4998..7550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021963.4 → NP_068798.1  nucleosome assembly protein 1-like 2

      Status: REVIEWED

      Source sequence(s)
      AB027013, AK316569, CB242638
      Consensus CDS
      CCDS14423.1
      UniProtKB/Swiss-Prot
      B2RE61, B4E161, Q8TAN6, Q9ULW6
      UniProtKB/TrEMBL
      A8K5I2
      Related
      ENSP00000362616.3, ENST00000373517.4
      Conserved Domains (1) summary
      pfam00956
      Location:111 → 410
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      73212299..73214851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      71645741..71648293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULW6.1 GenPept UniProtKB/Swiss-Prot:Q9ULW6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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