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    Cntrl centriolin [ Mus musculus (house mouse) ]

    Gene ID: 26920, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cntrlprovided by MGI
    Official Full Name
    centriolinprovided by MGI
    Primary source
    MGI:MGI:1889576
    See related
    Ensembl:ENSMUSG00000057110 AllianceGenome:MGI:1889576
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cep1; IB3/5; Ma2a8; Cep110; b2b1468Clo; b2b1468.1Clo; 6720467O09Rik
    Summary
    Predicted to enable dynein complex binding activity. Acts upstream of or within circulatory system development; female germ-line stem cell asymmetric division; and kidney development. Located in meiotic spindle pole; mitotic spindle pole; and perinuclear region of cytoplasm. Is expressed in cerebral cortex ventricular layer; midbrain ventricular layer; and telencephalon ventricular layer. Used to study nephronophthisis. Orthologous to human CNTRL (centriolin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.2), thymus adult (RPKM 3.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cntrl in Genome Data Viewer
    Location:
    2 B; 2 23.36 cM
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34999504..35068834)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (35109476..35178822)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene hemolytic complement Neighboring gene STARR-seq mESC enhancer starr_04276 Neighboring gene predicted gene, 39794 Neighboring gene expressed sequence AI182371 Neighboring gene STARR-positive B cell enhancer ABC_E4440 Neighboring gene STARR-positive B cell enhancer ABC_E2616 Neighboring gene STARR-positive B cell enhancer ABC_E5906 Neighboring gene RAB14, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E7811 Neighboring gene predicted gene 13605 Neighboring gene predicted gene, 52553

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Centriolin, a centriole-appendage protein, regulates peripheral spindle migration and asymmetric division in mouse meiotic oocytes. Sun TY, et al. Cell Cycle, 2017 Oct 2. PMID 28075662, Free PMC Article
    2. Molecular cloning of a cDNA encoding an antigen which is salt-stably attached to centrosomes. Angiolillo A, et al. Biochim Biophys Acta, 1996 Dec 11. PMID 8982254
    3. Assignment of the centrosomal protein 110 gene (Cep110) to mouse chromosome bands 2B-C1 by in situ hybridization. Popovici C, et al. Cytogenet Cell Genet, 2000. PMID 10965126
    4. Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models. Ren M, et al. Blood, 2013 Aug 8. PMID 23777766, Free PMC Article
    5. Planar cell polarity induces local microtubule bundling for coordinated ciliary beating. Nakayama S, et al. J Cell Biol, 2021 Jul 5. PMID 33929515, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Centriolin depletion affects spindle size and peripheral spindle migration in oocytes.
      Title: Centriolin, a centriole-appendage protein, regulates peripheral spindle migration and asymmetric division in mouse meiotic oocytes.
    2. CNTRL and FGFR1 have roles in myeloid and lymphoid malignancies in both human and mouse models
      Title: Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aorta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cardiac septum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within female germ-line stem cell asymmetric division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of centriolar subdistal appendage IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in meiotic spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    centriolin
    Names
    110 kDa centrosomal protein
    antigen identified by monoclonal antibody 2A8
    centrosomal protein 110
    centrosomal protein of 110 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290635.1 → NP_001277564.1  centriolin isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several 5' and 3' exons but contains alternate 5' and 3' terminal exons, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus and has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      BC060146, BY032373
      UniProtKB/TrEMBL
      A2AS42
      Related
      ENSMUSP00000108656.3, ENSMUST00000113033.6
      Conserved Domains (1) summary
      pfam01496
      Location:173 → 259
      V_ATPase_I; V-type ATPase 116kDa subunit family

    2. NM_001379274.1 → NP_001366203.1  centriolin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL773523, AL845534
      UniProtKB/Swiss-Prot
      A0A4W6, A0A4X1, A2AL36, A2AL37, A2AL40, Q6KAR8, Q8CHX3, Q9CRM3
      UniProtKB/TrEMBL
      B2RXX1
      Related
      ENSMUSP00000028237.9, ENSMUST00000028237.15
      Conserved Domains (6) summary
      COG1196
      Location:440 → 1134
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1407 → 2216
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam06346
      Location:1239 → 1310
      Drf_FH1; Formin Homology Region 1
      cd21340
      Location:89 → 261
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    3. NM_001379275.1 → NP_001366204.1  centriolin isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL773523, AL845534
      Conserved Domains (3) summary
      COG1196
      Location:2 → 581
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:854 → 1663
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06346
      Location:686 → 757
      Drf_FH1; Formin Homology Region 1

    4. NM_012018.2 → NP_036148.2  centriolin isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL773523, AL845534
      Consensus CDS
      CCDS57170.2
      UniProtKB/TrEMBL
      B2RXX1, R4GML3
      Related
      ENSMUSP00000108655.3, ENSMUST00000113032.8
      Conserved Domains (9) summary
      COG1196
      Location:440 → 1133
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00116
      Location:86 → 228
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam14580
      Location:83 → 279
      LRR_9; Leucine-rich repeat
      TIGR02168
      Location:1406 → 2215
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam06346
      Location:1238 → 1309
      Drf_FH1; Formin Homology Region 1
      pfam07851
      Location:1955 → 2046
      TMPIT; TMPIT-like protein
      pfam12799
      Location:148 → 185
      LRR_4; Leucine Rich repeats (2 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      34999504..35068834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251616.2 → XP_030107476.1  centriolin isoform X2

      UniProtKB/TrEMBL
      B2RXX1
      Conserved Domains (5) summary
      COG1196
      Location:287 → 981
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1254 → 2063
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00031
      Location:18 → 41
      LRR_1; leucine-rich repeat [structural motif]
      pfam06346
      Location:1086 → 1157
      Drf_FH1; Formin Homology Region 1
      pfam14580
      Location:8 → 126
      LRR_9; Leucine-rich repeat

    2. XM_006498069.4 → XP_006498132.1  centriolin isoform X1

      UniProtKB/TrEMBL
      B2RXX1
      Conserved Domains (8) summary
      PHA02562
      Location:304 → 538
      46; endonuclease subunit; Provisional
      COG1196
      Location:440 → 1134
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1407 → 2214
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam06346
      Location:1239 → 1310
      Drf_FH1; Formin Homology Region 1
      pfam14580
      Location:152 → 279
      LRR_9; Leucine-rich repeat
      pfam12799
      Location:126 → 167
      LRR_4; Leucine Rich repeats (2 copies)

    3. XM_036162232.1 → XP_036018125.1  centriolin isoform X3

      UniProtKB/TrEMBL
      B2RXX1
      Conserved Domains (6) summary
      COG1196
      Location:440 → 1134
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1407 → 2083
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00031
      Location:100 → 119
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:127 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      pfam06346
      Location:1239 → 1310
      Drf_FH1; Formin Homology Region 1
      cd21340
      Location:89 → 261
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    4. XM_030251617.2 → XP_030107477.1  centriolin isoform X4

      UniProtKB/TrEMBL
      B2RXX1
      Conserved Domains (3) summary
      COG1196
      Location:44 → 738
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:1011 → 1820
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06346
      Location:843 → 914
      Drf_FH1; Formin Homology Region 1

    5. XM_036162235.1 → XP_036018128.1  centriolin isoform X8

      Conserved Domains (3) summary
      COG1196
      Location:2 → 580
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:853 → 1660
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06346
      Location:685 → 756
      Drf_FH1; Formin Homology Region 1

    6. XM_030251620.2 → XP_030107480.1  centriolin isoform X5

      Conserved Domains (3) summary
      COG1196
      Location:2 → 581
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:854 → 1663
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06346
      Location:686 → 757
      Drf_FH1; Formin Homology Region 1

    7. XM_006498073.5 → XP_006498136.1  centriolin isoform X5

      See identical proteins and their annotated locations for XP_006498136.1

      Conserved Domains (3) summary
      COG1196
      Location:2 → 581
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:854 → 1663
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06346
      Location:686 → 757
      Drf_FH1; Formin Homology Region 1

    8. XM_006498074.5 → XP_006498137.1  centriolin isoform X5

      See identical proteins and their annotated locations for XP_006498137.1

      Conserved Domains (3) summary
      COG1196
      Location:2 → 581
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:854 → 1663
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06346
      Location:686 → 757
      Drf_FH1; Formin Homology Region 1

    9. XM_036162233.1 → XP_036018126.1  centriolin isoform X6

      UniProtKB/TrEMBL
      E9Q9E7
      Related
      ENSMUSP00000108660.4, ENSMUST00000113037.10
      Conserved Domains (3) summary
      COG1196
      Location:2 → 580
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:853 → 1662
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06346
      Location:685 → 756
      Drf_FH1; Formin Homology Region 1

    10. XM_006498075.5 → XP_006498138.1  centriolin isoform X5

      See identical proteins and their annotated locations for XP_006498138.1

      Conserved Domains (3) summary
      COG1196
      Location:2 → 581
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:854 → 1663
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06346
      Location:686 → 757
      Drf_FH1; Formin Homology Region 1

    11. XM_036162234.1 → XP_036018127.1  centriolin isoform X7

      Conserved Domains (3) summary
      COG1196
      Location:2 → 581
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:854 → 1661
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06346
      Location:686 → 757
      Drf_FH1; Formin Homology Region 1

    RNA

    1. XR_004940615.1 RNA Sequence

    2. XR_004940616.1 RNA Sequence

    3. XR_004940618.1 RNA Sequence

    4. XR_004940617.1 RNA Sequence

    5. XR_004940619.1 RNA Sequence

    6. XR_866015.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_030000.2: Suppressed sequence

      Description
      NM_030000.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AL36.2 GenPept UniProtKB/Swiss-Prot:A2AL36

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