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    Cep192 centrosomal protein 192 [ Mus musculus (house mouse) ]

    Gene ID: 70799, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cep192provided by MGI
    Official Full Name
    centrosomal protein 192provided by MGI
    Primary source
    MGI:MGI:1918049
    See related
    Ensembl:ENSMUSG00000024542 AllianceGenome:MGI:1918049
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4631422C13Rik; D430014P18Rik
    Summary
    Predicted to enable phosphatase binding activity and protein kinase binding activity. Acts upstream of or within response to bacterium. Located in cytoplasm and pericentriolar material. Is expressed in cerebral cortex ventricular layer and meninges. Orthologous to human CEP192 (centrosomal protein 192). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.7), limb E14.5 (RPKM 5.8) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cep192 in Genome Data Viewer
    Location:
    18 E1- E2; 18 40.11 cM
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (67933124..68018241)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (67800054..67885170)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930549G23 gene Neighboring gene STARR-positive B cell enhancer ABC_E11001 Neighboring gene STARR-positive B cell enhancer ABC_E1518 Neighboring gene predicted gene, 26910 Neighboring gene STARR-positive B cell enhancer ABC_E11662 Neighboring gene SEH1-like (S. cerevisiae Neighboring gene STARR-seq mESC enhancer starr_44916 Neighboring gene STARR-seq mESC enhancer starr_44917 Neighboring gene STARR-seq mESC enhancer starr_44919 Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene STARR-seq mESC enhancer starr_44922 Neighboring gene low density lipoprotein receptor class A domain containing 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:68126707-68126976 Neighboring gene predicted gene, 52336

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192. Guo J, et al. HGG Adv, 2024 Jan 11. PMID 37981762, Free PMC Article
    2. Distinct roles of Cep192 and Cep152 in acentriolar MTOCs and spindle formation during mouse oocyte maturation. Lee IW, et al. FASEB J, 2018 Feb. PMID 28970258
    3. CIP2A acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation. Wang H, et al. Development, 2017 Oct 15. PMID 28935709
    4. The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis. Zhu F, et al. Curr Biol, 2008 Jan 22. PMID 18207742
    5. A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve. Siguero-Álvarez M, et al. Circulation, 2023 Jan 3. PMID 36325906

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192.
      Title: Mosaic variegated aneuploidy syndrome with tetraploid, and predisposition to male infertility triggered by mutant CEP192.
    2. results demonstrate the different roles of Cep192 and Cep152 in MTOC remodeling and a novel regulatory mechanism during meiotic spindle formation in mouse oocytes.
      Title: Distinct roles of Cep192 and Cep152 in acentriolar MTOCs and spindle formation during mouse oocyte maturation.
    3. CIP2A acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation in mouse oocytes
      Title: CIP2A acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centrosome-templated microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein localization to centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in pericentriolar material IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in procentriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of procentriole replication complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 192 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027556.1 → NP_081832.1  centrosomal protein of 192 kDa

      Status: VALIDATED

      Source sequence(s)
      AC127236, AK052420, AK158414, BC064462, BE982606, CD538408, CK391255, CK639048, CO045915
      Consensus CDS
      CCDS50313.1
      UniProtKB/TrEMBL
      E9Q4Y4
      Related
      ENSMUSP00000025425.6, ENSMUST00000025425.7
      Conserved Domains (1) summary
      cl13764
      Location:1636 → 1703
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      67933124..68018241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526241.3 → XP_006526304.1  centrosomal protein of 192 kDa isoform X1

      See identical proteins and their annotated locations for XP_006526304.1

      Conserved Domains (2) summary
      pfam08626
      Location:1651 → 1772
      TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
      cl13764
      Location:1636 → 1703
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    2. XM_011247001.4 → XP_011245303.1  centrosomal protein of 192 kDa isoform X5

      Conserved Domains (2) summary
      pfam08626
      Location:1651 → 1772
      TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
      cl13764
      Location:1636 → 1703
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    3. XM_006526243.4 → XP_006526306.1  centrosomal protein of 192 kDa isoform X2

      Conserved Domains (2) summary
      pfam08626
      Location:1608 → 1729
      TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
      cl13764
      Location:1593 → 1660
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    4. XM_006526242.3 → XP_006526305.1  centrosomal protein of 192 kDa isoform X1

      See identical proteins and their annotated locations for XP_006526305.1

      Conserved Domains (2) summary
      pfam08626
      Location:1651 → 1772
      TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
      cl13764
      Location:1636 → 1703
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    5. XM_036161275.1 → XP_036017168.1  centrosomal protein of 192 kDa isoform X3

      Conserved Domains (1) summary
      cl13764
      Location:1406 → 1473
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    6. XM_011247000.4 → XP_011245302.1  centrosomal protein of 192 kDa isoform X4

      Conserved Domains (2) summary
      pfam08626
      Location:1019 → 1140
      TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit
      cl13764
      Location:1004 → 1071
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    Nucleotide Protein Strain
    Heading Accession and Version

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