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    Pygl liver glycogen phosphorylase [ Mus musculus (house mouse) ]

    Gene ID: 110095, updated on 2-Nov-2024

    Summary

    Official Symbol
    Pyglprovided by MGI
    Official Full Name
    liver glycogen phosphorylaseprovided by MGI
    Primary source
    MGI:MGI:97829
    See related
    Ensembl:ENSMUSG00000021069 AllianceGenome:MGI:97829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables glycogen phosphorylase activity. Involved in glycogen catabolic process. Acts upstream of or within necroptotic process and response to bacterium. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; cranium; sensory organ; and urinary system. Used to study glycogen storage disease VI. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease VI; and lactic acidosis. Orthologous to human PYGL (glycogen phosphorylase L). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 115.1), liver E18 (RPKM 102.5) and 12 other tissues See more
    Orthologs
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    Genomic context

    See Pygl in Genome Data Viewer
    Location:
    12 C2; 12 29.01 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (70237589..70274457, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (70190815..70227683, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:71246077-71246378 Neighboring gene predicted gene, 53726 Neighboring gene abhydrolase domain containing 12B Neighboring gene STARR-seq mESC enhancer starr_32387 Neighboring gene RIKEN cDNA F730035M05 gene Neighboring gene STARR-seq mESC enhancer starr_32388 Neighboring gene predicted gene, 38467 Neighboring gene tripartite motif-containing 9 Neighboring gene STARR-seq mESC enhancer starr_32389

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1,4-alpha-oligoglucan phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables D-glucose binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables D-glucose binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables bile acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables bile acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycogen phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glycogen phosphorylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glycogen phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables purine nucleobase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables purine nucleobase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables vitamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycogen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    glycogen phosphorylase, liver form
    NP_573461.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133198.2NP_573461.2  glycogen phosphorylase, liver form

      See identical proteins and their annotated locations for NP_573461.2

      Status: VALIDATED

      Source sequence(s)
      AK145989, BY435276
      Consensus CDS
      CCDS25957.1
      UniProtKB/Swiss-Prot
      Q3UKJ0, Q9ET01
      UniProtKB/TrEMBL
      Q91WP9
      Related
      ENSMUSP00000071231.7, ENSMUST00000071250.13
      Conserved Domains (2) summary
      cd04300
      Location:29827
      GT1_Glycogen_Phosphorylase; This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of ...
      TIGR02093
      Location:32827
      P_ylase; glycogen/starch/alpha-glucan phosphorylases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      70237589..70274457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)