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    Zbtb20 zinc finger and BTB domain containing 20 [ Mus musculus (house mouse) ]

    Gene ID: 56490, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Zbtb20provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 20provided by MGI
    Primary source
    MGI:MGI:1929213
    See related
    Ensembl:ENSMUSG00000022708 AllianceGenome:MGI:1929213
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HOF; J20; DPZF; Oda8; ODA-8S; Zfp288; D16Wsu73e; 1300017A20Rik; 7330412A13Rik; A930017C21Rik; Tg(PDGFB-APPSwInd)20Lms
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of glycolytic process; and regulation of gene expression. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study Alzheimer's disease. Orthologous to human ZBTB20 (zinc finger and BTB domain containing 20). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 5.3), heart adult (RPKM 4.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb20 in Genome Data Viewer
    Location:
    16 B4; 16 28.44 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (42728008..43462981)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (42875689..43634392)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4932412D23 gene Neighboring gene predicted gene, 29960 Neighboring gene STARR-seq mESC enhancer starr_40870 Neighboring gene STARR-positive B cell enhancer mm9_chr16:42836127-42836428 Neighboring gene STARR-seq mESC enhancer starr_40871 Neighboring gene STARR-positive B cell enhancer ABC_E52 Neighboring gene predicted gene, 19522 Neighboring gene STARR-seq mESC enhancer starr_40874 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S5, pseudogene Neighboring gene STARR-seq mESC enhancer starr_40875 Neighboring gene STARR-seq mESC enhancer starr_40877 Neighboring gene STARR-seq mESC enhancer starr_40878 Neighboring gene predicted gene, 25873 Neighboring gene ribosomal protein L3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40879 Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene predicted gene 9968 Neighboring gene STARR-seq mESC enhancer starr_40880 Neighboring gene predicted gene 15713 Neighboring gene STARR-seq mESC enhancer starr_40881 Neighboring gene STARR-positive B cell enhancer mm9_chr16:43507109-43507410 Neighboring gene STARR-seq mESC enhancer starr_40882 Neighboring gene STARR-seq mESC enhancer starr_40883 Neighboring gene STARR-seq mESC enhancer starr_40885 Neighboring gene STARR-positive B cell enhancer ABC_E7450 Neighboring gene STARR-positive B cell enhancer ABC_E4170 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:43690256-43690365 Neighboring gene microRNA 568 Neighboring gene predicted gene, 53956 Neighboring gene T cell immunoreceptor with Ig and ITIM domains

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Impact of Aging on Brain Pituitary Adenylate Cyclase Activating Polypeptide, Pathology and Cognition in Mice and Rhesus Macaques. Han P, et al. Front Aging Neurosci, 2017. PMID 28659785, Free PMC Article
    2. Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality. Martínez-Frailes C, et al. Front Cell Neurosci, 2019. PMID 31031598, Free PMC Article
    3. Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model. Fang F, et al. Biochim Biophys Acta, 2012 Feb. PMID 22015470, Free PMC Article
    4. Estrogen-Dominant Ovarian Cycle Stages Are Associated with Neural Network Dysfunction and Cognitive and Behavioral Deficits in the hAPP-J20 Mouse Model of Alzheimer's Disease. Carney RSE DPhil. eNeuro, 2019 May/Jun. PMID 31147386, Free PMC Article
    5. Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid. Henderson BW, et al. Sci Signal, 2019 Jun 25. PMID 31239325, Free PMC Article

    See all (368) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZBTB20 Regulates SERCA2a Activity and Myocardial Contractility Through Phospholamban.
      Title: ZBTB20 Regulates SERCA2a Activity and Myocardial Contractility Through Phospholamban.
    2. ZBTB20 is essential for cochlear maturation and hearing in mice.
      Title: ZBTB20 is essential for cochlear maturation and hearing in mice.
    3. ZBTB20 Regulates Prolactin Expression and Lactotrope Function in Adult Mice.
      Title: ZBTB20 Regulates Prolactin Expression and Lactotrope Function in Adult Mice.
    4. ZBTB20 regulates cardiac allograft rejection through NFsmall ka, CyrillicB-mediated inflammation in mouse heart transplantation.
      Title: ZBTB20 regulates cardiac allograft rejection through NFкB-mediated inflammation in mouse heart transplantation.
    5. Zbtb20 identifies and controls a thymus-derived population of regulatory T cells that play a role in intestinal homeostasis.
      Title: Zbtb20 identifies and controls a thymus-derived population of regulatory T cells that play a role in intestinal homeostasis.
    6. The zinc finger and BTB domain containing protein ZBTB20 regulates plasma triglyceride metabolism by repressing lipoprotein lipase gene transcription in hepatocytes.
      Title: The zinc finger and BTB domain containing protein ZBTB20 regulates plasma triglyceride metabolism by repressing lipoprotein lipase gene transcription in hepatocytes.
    7. An epigenetic circuit controls neurogenic programs during neocortex development.
      Title: An epigenetic circuit controls neurogenic programs during neocortex development.
    8. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.
      Title: ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.
    9. Zinc Finger Protein ZBTB20 protects against cardiac remodelling post-myocardial infarction via ROS-TNFalpha/ASK1/JNK pathway regulation.
      Title: Zinc Finger Protein ZBTB20 protects against cardiac remodelling post-myocardial infarction via ROS-TNFα/ASK1/JNK pathway regulation.
    10. Zbtb20 deficiency causes cardiac contractile dysfunction in mice.
      Title: Zbtb20 deficiency causes cardiac contractile dysfunction in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of interferon-beta production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 20
    Names
    APP Tg
    BTB/POZ domain zinc finger factor HOF
    PDGF-APPSwInd
    PDGF-hAPP695,751,770V171F, KM670/671NL
    POZ/zinc finger transcription factor ODA-8
    zinc finger protein 288

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285805.1 → NP_001272734.1  zinc finger and BTB domain-containing protein 20 isoform L

      See identical proteins and their annotated locations for NP_001272734.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variant 1 and 3 encode the same isoform (L).
      Source sequence(s)
      BC056446, BI659024
      Consensus CDS
      CCDS28178.1
      UniProtKB/Swiss-Prot
      A6X916, Q8K0L9, Q9DBD4, Q9QZ87
      UniProtKB/TrEMBL
      Q9QZF3
      Conserved Domains (5) summary
      sd00017
      Location:580 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:79 → 195
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:634 → 656
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:648 → 673
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:608 → 657
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    2. NM_001393397.1 → NP_001380326.1  zinc finger and BTB domain-containing protein 20 isoform L

      Status: VALIDATED

      Source sequence(s)
      AC120871, CT010512, CT010517
      UniProtKB/Swiss-Prot
      A6X916, Q8K0L9, Q9DBD4, Q9QZ87
      UniProtKB/TrEMBL
      Q9QZF3
      Related
      ENSMUSP00000110342.3, ENSMUST00000114694.9
      Conserved Domains (5) summary
      sd00017
      Location:580 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:79 → 195
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:634 → 656
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:648 → 673
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:608 → 657
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    3. NM_001393398.1 → NP_001380327.1  zinc finger and BTB domain-containing protein 20 isoform L

      Status: VALIDATED

      Source sequence(s)
      AC120871, CT010512, CT010517
      UniProtKB/Swiss-Prot
      A6X916, Q8K0L9, Q9DBD4, Q9QZ87
      UniProtKB/TrEMBL
      Q9QZF3
      Conserved Domains (5) summary
      sd00017
      Location:580 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:79 → 195
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:634 → 656
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:648 → 673
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:608 → 657
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    4. NM_001393399.1 → NP_001380328.1  zinc finger and BTB domain-containing protein 20 isoform S

      Status: VALIDATED

      Source sequence(s)
      AC120871, CT010512, CT010517
      UniProtKB/TrEMBL
      Q9QZF3
      Conserved Domains (6) summary
      COG5048
      Location:432 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:6 → 122
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:561 → 583
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:575 → 600
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:535 → 584
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    5. NM_019778.2 → NP_062752.2  zinc finger and BTB domain-containing protein 20 isoform L

      See identical proteins and their annotated locations for NP_062752.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (L).
      Source sequence(s)
      AK005028, BC056446
      Consensus CDS
      CCDS28178.1
      UniProtKB/Swiss-Prot
      A6X916, Q8K0L9, Q9DBD4, Q9QZ87
      UniProtKB/TrEMBL
      Q9QZF3
      Related
      ENSMUSP00000078410.7, ENSMUST00000079441.13
      Conserved Domains (5) summary
      sd00017
      Location:580 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:79 → 195
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:634 → 656
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:648 → 673
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:608 → 657
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    6. NM_181058.1 → NP_851401.1  zinc finger and BTB domain-containing protein 20 isoform S

      See identical proteins and their annotated locations for NP_851401.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate 5' UTR exon and the alternate exon containing the translation start site compared to variant 1. The resulting isoform (S) is shorter at the N-terminus compared to isoform L.
      Source sequence(s)
      AK005028, BC056446
      Consensus CDS
      CCDS49851.1
      UniProtKB/TrEMBL
      Q9QZF3
      Related
      ENSMUSP00000110339.2, ENSMUST00000114691.8
      Conserved Domains (6) summary
      COG5048
      Location:432 → 574
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18208
      Location:6 → 122
      BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
      pfam00096
      Location:561 → 583
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:575 → 600
      zf-H2C2_2; Zinc-finger double domain
      cd20908
      Location:535 → 584
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      42728008..43462981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0L9.1 GenPept UniProtKB/Swiss-Prot:Q8K0L9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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