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    Zfp708 zinc finger protein 708 [ Mus musculus (house mouse) ]

    Gene ID: 432769, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp708provided by MGI
    Official Full Name
    zinc finger protein 708provided by MGI
    Primary source
    MGI:MGI:3040674
    See related
    Ensembl:ENSMUSG00000058883 AllianceGenome:MGI:3040674
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rslcan11
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF28 (zinc finger protein 28); ZNF429 (zinc finger protein 429); and ZNF611 (zinc finger protein 611). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 2.3), CNS E14 (RPKM 2.1) and 22 other tissues See more
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    Genomic context

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    See Zfp708 in Genome Data Viewer
    Location:
    13 B3; 13 34.54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67217462..67246040, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67069398..67097976, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene phosphatidylserine synthase 1 Neighboring gene RIKEN cDNA 4933433G19 gene Neighboring gene STARR-seq mESC enhancer starr_34892 Neighboring gene zinc finger protein 712 Neighboring gene STARR-positive B cell enhancer ABC_E3085 Neighboring gene STARR-positive B cell enhancer ABC_E9879 Neighboring gene uncharacterized LOC118568057 Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1465 Neighboring gene regulator of sex-limitation candidate 18 Neighboring gene zinc finger protein 759 Neighboring gene STARR-seq mESC enhancer starr_34894 Neighboring gene STARR-positive B cell enhancer ABC_E2411 Neighboring gene regulator of sex limited protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons. Seah MKY, et al. Development, 2019 Jul 10. PMID 30846446, Free PMC Article
    2. Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2. Krebs CJ, et al. Genomics, 2005 Jun. PMID 15885501
    3. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs CJ, et al. Genes Dev, 2003 Nov 1. PMID 14563677, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZFP708 recruits the repressive TRIM28 complex to RMER19B retrotransposons to evoke regional heterochromatin formation.
      Title: The KRAB-zinc-finger protein ZFP708 mediates epigenetic repression at RMER19B retrotransposons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102251

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 708
    Names
    regulator of sex-limitation candidate 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012325.2 → NP_001012325.2  zinc finger protein 708 isoform a

      See identical proteins and their annotated locations for NP_001012325.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BC089368, CF174027
      UniProtKB/TrEMBL
      F8VPP0
      Related
      ENSMUSP00000105365.4, ENSMUST00000109743.5
      Conserved Domains (5) summary
      smart00349
      Location:17 → 77
      KRAB; krueppel associated box
      COG5048
      Location:119 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:17 → 56
      KRAB; KRAB box
      pfam13465
      Location:303 → 328
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001012448.2 → NP_001012450.2  zinc finger protein 708 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a shorter and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      BB612019, BC089368
      Consensus CDS
      CCDS49298.1
      UniProtKB/TrEMBL
      F2Z422
      Related
      ENSMUSP00000105364.4, ENSMUST00000109742.11
      Conserved Domains (5) summary
      smart00349
      Location:5 → 65
      KRAB; krueppel associated box
      COG5048
      Location:107 → 528
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:279 → 299
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:5 → 44
      KRAB; KRAB box
      pfam13465
      Location:291 → 316
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001012449.2 → NP_001012451.2  zinc finger protein 708 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform c).
      Source sequence(s)
      BC089368, CF174027
      Conserved Domains (5) summary
      smart00349
      Location:17 → 62
      KRAB; krueppel associated box
      COG5048
      Location:87 → 508
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:17 → 56
      KRAB; KRAB box
      pfam13465
      Location:271 → 296
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001292066.1 → NP_001278995.1  zinc finger protein 708 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK132353, BC089368
      Consensus CDS
      CCDS79206.1
      UniProtKB/TrEMBL
      A0A087WPV0
      Related
      ENSMUSP00000139928.2, ENSMUST00000190566.3
      Conserved Domains (4) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:74 → 495
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:246 → 266
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:258 → 283
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      67217462..67246040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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