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    Gstt3 glutathione S-transferase, theta 3 [ Mus musculus (house mouse) ]

    Gene ID: 103140, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gstt3provided by MGI
    Official Full Name
    glutathione S-transferase, theta 3provided by MGI
    Primary source
    MGI:MGI:2143526
    See related
    Ensembl:ENSMUSG00000001665 AllianceGenome:MGI:2143526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables glutathione transferase activity. Acts upstream of or within glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; metatarsal bone; olfactory epithelium; submandibular gland primordium; and urinary system. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver adult (RPKM 70.4), bladder adult (RPKM 44.4) and 16 other tissues See more
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    Genomic context

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    See Gstt3 in Genome Data Viewer
    Location:
    10 C1; 10 38.58 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75609951..75617256, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75774117..75781422, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene cytochrome b-c1 complex subunit 7 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9346 Neighboring gene D-dopachrome tautomerase Neighboring gene glutathione S-transferase, theta 1 Neighboring gene glutathione S-transferase, theta 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of GSTT3, a third murine Theta class glutathione transferase. Coggan M, et al. Biochem J, 2002 Aug 15. PMID 12038961, Free PMC Article
    2. A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice. Endoh-Yamagami S, et al. Dev Biol, 2010 Apr 1. PMID 20096683
    3. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification and characterization of GSTT3 [GSTT3]
      Title: Identification and characterization of GSTT3, a third murine Theta class glutathione transferase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase theta-3
    NP_001333452.1
    NP_598755.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346523.1 → NP_001333452.1  glutathione S-transferase theta-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC142499, AK138669, BY232658, CX204823
      Consensus CDS
      CCDS88023.1
      UniProtKB/TrEMBL
      G3UX05
      Related
      ENSMUSP00000133498.2, ENSMUST00000173537.2

    2. NM_133994.3 → NP_598755.1  glutathione S-transferase theta-3 isoform 1

      See identical proteins and their annotated locations for NP_598755.1

      Status: VALIDATED

      Source sequence(s)
      AC142499
      Consensus CDS
      CCDS23931.1
      UniProtKB/Swiss-Prot
      Q6P6I4, Q99L20
      Related
      ENSMUSP00000001715.4, ENSMUST00000001715.10
      Conserved Domains (3) summary
      cd03183
      Location:92 → 216
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      COG0625
      Location:3 → 217
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03050
      Location:3 → 78
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      75609951..75617256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99L20.1 GenPept UniProtKB/Swiss-Prot:Q99L20

    Gene LinkOut

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