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    Epcip exosomal polycystin 1 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 74387, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Epcipprovided by MGI
    Official Full Name
    exosomal polycystin 1 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1921637
    See related
    Ensembl:ENSMUSG00000039851 AllianceGenome:MGI:1921637
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4931406G06Rik; 4932438H23Rik
    Summary
    Predicted to be involved in mitocytosis. Predicted to be located in extracellular exosome. Predicted to be active in migrasome. Is expressed in several structures, including genitourinary system; heart; nervous system; sensory organ; and thymus. Orthologous to human EPCIP (exosomal polycystin 1 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 4.0), genital fat pad adult (RPKM 1.3) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Epcip in Genome Data Viewer
    Location:
    16 C3.3; 16 52.35 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (90841534..90866040, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91054877..91130103, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene synaptojanin 1 Neighboring gene RIKEN cDNA 4930404I05 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:91012148-91012449 Neighboring gene STARR-seq mESC enhancer starr_41471 Neighboring gene PAX3 and PAX7 binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_41472 Neighboring gene STARR-positive B cell enhancer ABC_E8977 Neighboring gene H3.3 histone A, pseudogene 2 Neighboring gene VISTA enhancer mm817 Neighboring gene STARR-seq mESC enhancer starr_41473 Neighboring gene predicted gene, 41492 Neighboring gene predicted gene 9881

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
    2. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular exosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in migrasome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in migrasome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in migrasome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    exosomal polycystin-1-interacting protein; polycystin-1-interacting protein 1
    Names
    uncharacterized protein C21orf62 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163695.2 → NP_001157167.2  exosomal polycystin-1-interacting protein precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC141885
      Related
      ENSMUSP00000109710.2, ENSMUST00000114076.2
      Conserved Domains (1) summary
      pfam15137
      Location:6 → 212
      DUF4571; Domain of unknown function (DUF4571)

    2. NM_028905.4 → NP_083181.2  exosomal polycystin-1-interacting protein precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC141885
      Related
      ENSMUSP00000040111.2, ENSMUST00000035689.8
      Conserved Domains (1) summary
      pfam15137
      Location:6 → 212
      DUF4571; Domain of unknown function (DUF4571)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      90841534..90866040 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160168.1 → XP_036016061.1  polycystin-1-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q544A2, Q9D4G1
      Conserved Domains (1) summary
      pfam15137
      Location:24 → 230
      DUF4571; Domain of unknown function (DUF4571)

    2. XM_036160167.1 → XP_036016060.1  polycystin-1-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q544A2, Q9D4G1
      Conserved Domains (1) summary
      pfam15137
      Location:24 → 230
      DUF4571; Domain of unknown function (DUF4571)

    3. XM_030249315.2 → XP_030105175.1  polycystin-1-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q544A2, Q9D4G1
      Conserved Domains (1) summary
      pfam15137
      Location:24 → 230
      DUF4571; Domain of unknown function (DUF4571)

    4. XM_030249314.2 → XP_030105174.1  polycystin-1-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q544A2, Q9D4G1
      Conserved Domains (1) summary
      pfam15137
      Location:24 → 230
      DUF4571; Domain of unknown function (DUF4571)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4G1.1 GenPept UniProtKB/Swiss-Prot:Q9D4G1

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