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    Ptbp2 polypyrimidine tract binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 56195, updated on 2-Nov-2024

    Summary

    Official Symbol
    Ptbp2provided by MGI
    Official Full Name
    polypyrimidine tract binding protein 2provided by MGI
    Primary source
    MGI:MGI:1860489
    See related
    Ensembl:ENSMUSG00000028134 AllianceGenome:MGI:1860489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ptb2; nPTB; brPTB
    Summary
    Enables mRNA binding activity. Acts upstream of or within mRNA splice site recognition and regulation of neural precursor cell proliferation. Part of spliceosomal complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PTBP2 (polypyrimidine tract binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E14 (RPKM 48.5), whole brain E14.5 (RPKM 48.4) and 12 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ptbp2 in Genome Data Viewer
    Location:
    3 G1; 3 52.18 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (119512390..119578296, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (119718741..119784647, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08825 Neighboring gene predicted gene, 23432 Neighboring gene ribosomal protein S20 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08826 Neighboring gene ribonucleotide reductase M2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08827 Neighboring gene predicted gene, 23733

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    polypyrimidine tract-binding protein 2
    Names
    RRM-type RNA-binding protein brPTB
    brain-enriched PTB
    brain-enriched polypyrimidine tract-binding protein
    neural polypyrimidine tract-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310711.2NP_001297640.1  polypyrimidine tract-binding protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001297640.1

      Status: VALIDATED

      Source sequence(s)
      AC111029
      Consensus CDS
      CCDS80010.1
      UniProtKB/Swiss-Prot
      Q7TNW7, Q91Z31, Q9CUW2, Q9QYC2, Q9R0V9
      Related
      ENSMUSP00000143510.2, ENSMUST00000200097.5
      Conserved Domains (1) summary
      TIGR01649
      Location:57531
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    2. NM_001428875.1NP_001415804.1  polypyrimidine tract-binding protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC111029
    3. NM_001428876.1NP_001415805.1  polypyrimidine tract-binding protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC111029
    4. NM_019550.3NP_062423.1  polypyrimidine tract-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_062423.1

      Status: VALIDATED

      Source sequence(s)
      AC111029
      Consensus CDS
      CCDS38616.1
      UniProtKB/Swiss-Prot
      Q91Z31
      Related
      ENSMUSP00000029780.8, ENSMUST00000029780.12
      Conserved Domains (1) summary
      TIGR01649
      Location:57532
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    RNA

    1. NR_190519.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC111029
    2. NR_190520.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC111029
    3. NR_190521.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC111029
    4. NR_190522.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC111029

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      119512390..119578296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501731.2XP_006501794.1  polypyrimidine tract-binding protein 2 isoform X1

      Conserved Domains (1) summary
      TIGR01649
      Location:57537
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    2. XM_006501732.3XP_006501795.1  polypyrimidine tract-binding protein 2 isoform X2

      Conserved Domains (1) summary
      TIGR01649
      Location:57536
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    RNA

    1. XR_001783719.3 RNA Sequence

    2. XR_375550.4 RNA Sequence

    3. XR_375549.3 RNA Sequence

    4. XR_001783718.3 RNA Sequence