Cd53 CD53 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd53provided by MGI
Official Full Name: CD53 antigenprovided by MGI
Primary source: MGI:MGI:88341
See related: Ensembl:ENSMUSG00000040747 AllianceGenome:MGI:88341
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ox-44; Tspan25
Summary: Predicted to enable identical protein binding activity and protein-membrane adaptor activity. Involved in positive regulation of myoblast fusion. Located in cell-cell junction and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Orthologous to human CD53 (CD53 molecule). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in spleen adult (RPKM 20.6), mammary gland adult (RPKM 14.1) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.3; 3 46.53 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (106666177..106697465, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (106758861..106790149, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cutting Edge: The Tetraspanin CD53 Promotes CXCR4 Signaling and Bone Marrow Homing in B Cells.
Title: Cutting Edge: The Tetraspanin CD53 Promotes CXCR4 Signaling and Bone Marrow Homing in B Cells.
The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes.
Title: The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes.
Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function.
Title: Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function.
Tetraspanin CD53 modulates lymphocyte trafficking but not systemic autoimmunity in Lyn-deficient mice.
Title: Tetraspanin CD53 modulates lymphocyte trafficking but not systemic autoimmunity in Lyn-deficient mice.
Open conformation of tetraspanins shapes interaction partner networks on cell membranes.
Title: Open conformation of tetraspanins shapes interaction partner networks on cell membranes.
Leukocyte Tetraspanin CD53 Restrains alpha3 Integrin Mobilization and Facilitates Cytoskeletal Remodeling and Transmigration in Mice.
Title: Leukocyte Tetraspanin CD53 Restrains α(3) Integrin Mobilization and Facilitates Cytoskeletal Remodeling and Transmigration in Mice.
The Cd53(-/-) mice have reduced surface expression of IL-7Ralpha and diminished phosphatidylinositol 3 kinase and JAK/STAT signaling in prepro- and pro-B cells.
Title: The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling.
Cd53-deficient B cells were defective in the phosphorylation of protein kinase C substrates.
Title: Tetraspanin microdomains control localized protein kinase C signaling in B cells.
CD53 has a role in macrophage protection against LPS-induced oxidative stress and UVB irradiation
Title: LPS-induced CD53 expression: a protection mechanism against oxidative and radiation stress.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

AI323659 (e-PCR)
- UniSTS:178914

Cd53 (e-PCR), detects polymorphism
- UniSTS:141290

D2Arb17 (e-PCR), detects polymorphism
- UniSTS:227315

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein-membrane adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-membrane adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT involved_in cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of myoblast fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor clustering	IEA Inferred from Electronic Annotation more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of myoblast differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in immunological synapse	IEA Inferred from Electronic Annotation more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leukocyte surface antigen CD53

Names: cell surface glycoprotein CD53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007651.3 → NP_031677.1 leukocyte surface antigen CD53

See identical proteins and their annotated locations for NP_031677.1

Status: VALIDATED

Source sequence(s)

AA177409, AC117255, AK160326

Consensus CDS

CCDS17728.1

UniProtKB/Swiss-Prot

Q61451, Q61721

UniProtKB/TrEMBL

Q3TV80, Q3U0W1

Related

ENSMUSP00000035781.9, ENSMUST00000038845.10

Conserved Domains (2) summary

cd03164
Location:104 → 186

CD53_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

pfam00335
Location:9 → 210

Tetraspannin; Tetraspanin family