PLAAT1 phospholipase A and acyltransferase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLAAT1provided by HGNC
Official Full Name: phospholipase A and acyltransferase 1provided by HGNC
Primary source: HGNC:HGNC:14922
See related: Ensembl:ENSG00000127252 MIM:606487; AllianceGenome:HGNC:14922
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: A-C1; HRSL1; HSD28; HRASLS; HRASLS1; PLA/AT1; PLAAT-1; H-REV107
Summary: Enables acyltransferase activity, transferring groups other than amino-acyl groups and phospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process and phosphatidylcholine metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis (RPKM 17.3), thyroid (RPKM 1.8) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q29

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (193240606..193281426)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (195935989..195976800)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (192959011..192988644)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS on Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell Carcinoma.
Title: Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS on Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell Carcinoma.
A novel molecular mechanism describing K-Ras and H-REV107 binding is suggested and insights into new K-Ras effector target drugs are provided.
Title: Molecular interaction between K-Ras and H-REV107 in the Ras signaling pathway.
The HRASLS (PLA/AT) subfamily of enzymes.
Title: The HRASLS (PLA/AT) subfamily of enzymes.
a possible enzyme activity of A-C1
Title: Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes.
The phospholipase active site possesses a structurally conserved Cys-His-His triad as found in NlpC/P60 peptidases, indicating H-REV107 should adopt a similar catalytic mechanism towards phospholipid substrates to that of NlpC/P60 peptidases.
Title: Solution structure of the N-terminal catalytic domain of human H-REV107--a novel circular permutated NlpC/P60 domain.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

HRASLS (e-PCR)
- UniSTS:505530

SHGC-110035 (e-PCR)
- UniSTS:170178

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables N-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables calcium-independent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine 1-acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A1 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in N-acylphosphatidylethanolamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acylphosphatidylethanolamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lens fiber cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in organelle disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylcholine metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear envelope lumen	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phospholipase A and acyltransferase 1

Names: H-REV107 protein-related protein; HRAS like suppressor; HRAS-like suppressor 1; phospholipase A/acyltransferase 1; phospholipid-metabolizing enzyme A-C1

NP_001353041.1

EC 3.1.1.32

EC 3.1.1.4

NP_065119.3

EC 3.1.1.32

EC 3.1.1.4

XP_011511336.2

EC 3.1.1.32

EC 3.1.1.4

XP_011511337.2

EC 3.1.1.32

EC 3.1.1.4

XP_047304580.1

EC 3.1.1.32

EC 3.1.1.4

XP_047304581.1

EC 3.1.1.32

EC 3.1.1.4

XP_047304582.1

EC 3.1.1.32

EC 3.1.1.4

XP_054203328.1

EC 3.1.1.32

EC 3.1.1.4

XP_054203329.1

EC 3.1.1.32

EC 3.1.1.4

XP_054203330.1

EC 3.1.1.32

EC 3.1.1.4

XP_054203331.1

EC 3.1.1.32

EC 3.1.1.4

XP_054203332.1

EC 3.1.1.32

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001366112.1 → NP_001353041.1 phospholipase A and acyltransferase 1

Status: VALIDATED

Source sequence(s)

AC092966, AC105057

Consensus CDS

CCDS3303.3

UniProtKB/Swiss-Prot

D2KX19, Q6X7C0, Q86WS9, Q9HDD0, X6R3D1

Conserved Domains (1) summary

pfam04970
Location:26 → 130

LRAT; Lecithin retinol acyltransferase
NM_020386.5 → NP_065119.3 phospholipase A and acyltransferase 1

Status: VALIDATED

Source sequence(s)

BC048095, BX098792

Consensus CDS

CCDS3303.3

UniProtKB/Swiss-Prot

D2KX19, Q6X7C0, Q86WS9, Q9HDD0, X6R3D1

Related

ENSP00000264735.4, ENST00000264735.4

Conserved Domains (1) summary

pfam04970
Location:26 → 130

LRAT; Lecithin retinol acyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

193240606..193281426

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047448626.1 → XP_047304582.1 phospholipase A and acyltransferase 1 isoform X5

UniProtKB/Swiss-Prot

D2KX19, Q6X7C0, Q86WS9, Q9HDD0, X6R3D1
XM_011513035.3 → XP_011511337.2 phospholipase A and acyltransferase 1 isoform X2
XM_011513034.2 → XP_011511336.2 phospholipase A and acyltransferase 1 isoform X1
XM_047448625.1 → XP_047304581.1 phospholipase A and acyltransferase 1 isoform X4
XM_047448624.1 → XP_047304580.1 phospholipase A and acyltransferase 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

195935989..195976800

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054347357.1 → XP_054203332.1 phospholipase A and acyltransferase 1 isoform X5

UniProtKB/Swiss-Prot

D2KX19, Q6X7C0, Q86WS9, Q9HDD0, X6R3D1
XM_054347354.1 → XP_054203329.1 phospholipase A and acyltransferase 1 isoform X2
XM_054347353.1 → XP_054203328.1 phospholipase A and acyltransferase 1 isoform X1
XM_054347355.1 → XP_054203330.1 phospholipase A and acyltransferase 1 isoform X3
XM_054347356.1 → XP_054203331.1 phospholipase A and acyltransferase 1 isoform X4