Ifnar2 interferon (alpha and beta) receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifnar2provided by MGI
Official Full Name: interferon (alpha and beta) receptor 2provided by MGI
Primary source: MGI:MGI:1098243
See related: Ensembl:ENSMUSG00000022971 AllianceGenome:MGI:1098243
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IFN-R-2; Ifnar-2
Summary: Enables type I interferon receptor activity. Acts upstream of or within immature T cell proliferation in thymus and regulation of transcription by RNA polymerase II. Located in extracellular space. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; liver; and nervous system. Human ortholog(s) of this gene implicated in hepatitis B and immunodeficiency 45. Orthologous to human IFNAR2 (interferon alpha and beta receptor subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 31.7), lung adult (RPKM 17.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.3; 16 52.82 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (91166517..91202477)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (91372783..91405589)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads.
Title: Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads.
A role for IFNAR2 in induction of anti-IAV immune responses.
Title: IFNAR2 Is Required for Anti-influenza Immunity and Alters Susceptibility to Post-influenza Bacterial Superinfections.
Data, including data from studies in knockout and double-knockout mice, suggest complex and sex-specific roles of Ifnar1 and Ifnar2 in type 1 diabetes (T1D); female NOD mice develop T1D in absence of both Ifnar1 and Ifnar2, whereas male mice do not.
Title: Type I and II Interferon Receptors Differentially Regulate Type 1 Diabetes Susceptibility in Male Versus Female NOD Mice.
We found that STAT-1(-/-) MRL lpr m, but not IRF-9(-/-) or IFNAR-2(-/-) mice, developed interstitial nephritis characterized by infiltration with RORgammat-positive lymphocytes, macrophages, and eosinophils.
Title: Development of Th17-Associated Interstitial Kidney Inflammation in Lupus-Prone Mice Lacking the Gene Encoding STAT-1.
mTORC2 has a central role in IFNgamma signaling and type II IFN responses
Title: Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses.
In this study, we elucidate the in vivo importance of the soluble type I IFNAR, soluble (s)IFNAR2a
Title: Soluble IFN receptor potentiates in vivo type I IFN signaling and exacerbates TLR4-mediated septic shock.
Our studies provide a critical link between the IFN-I pathway and the regulation of TLR-specific B-cell responses in a murine model of Systemic lupus erythematosus
Title: Type I interferon receptor controls B-cell expression of nucleic acid-sensing Toll-like receptors and autoantibody production in a murine model of lupus.
ability of L. pneumophila to induce IFN-I expression was found to be dependent on IRF-3, but not NF-kappaB. Secreted IFN-Is then in turn suppress the intracellular replication of L. pneumophila
Title: Interferons direct an effective innate response to Legionella pneumophila infection.
Data show that that DC, especially the CD8alpha(+) subset, from type I IFN receptor knock out (IFNAR KO) mice, display a reduced turnover rate when compared with DC from WT mice.
Title: Type I IFN regulate DC turnover in vivo.
The local transgenic expression of GM-CSF in the stomach overrides any possible modulatory effects of IFNAR2 on experimental autoimmune gastritis development.
Title: GM-CSF-induced autoimmune gastritis in interferon alpha receptor deficient mice.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ifnar2 (e-PCR), detects polymorphism
- UniSTS:259091

Ifnar2 (e-PCR), detects polymorphism
- UniSTS:259620

AI747302 (e-PCR)
- UniSTS:160592

NoName (e-PCR)
- UniSTS:224359

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables interleukin-22 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables type I interferon binding	ISO Inferred from Sequence Orthology more info
enables type I interferon receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables type I interferon receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables type I interferon receptor activity	ISO Inferred from Sequence Orthology more info
enables type I interferon receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within immature T cell proliferation in thymus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-alpha	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-beta	ISS Inferred from Sequence or Structural Similarity more info
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: interferon alpha/beta receptor 2

Names: IFN-alpha/beta receptor 2; interferon receptor 2a'; interferon receptor 2c; type I interferon alpha/beta receptor 2a; type I interferon receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110498.1 → NP_001103968.1 interferon alpha/beta receptor 2 isoform b precursor

See identical proteins and their annotated locations for NP_001103968.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1, that results in a frameshift. It encodes isoform b, which has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AK003185, BE993108, BX515017

Consensus CDS

CCDS49910.1

UniProtKB/TrEMBL

Q9CS01, Q9D1R7

Related

ENSMUSP00000113358.2, ENSMUST00000117836.8

Conserved Domains (2) summary

pfam09294
Location:132 → 228

Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

cl21522
Location:42 → 107

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001347258.1 → NP_001334187.1 interferon alpha/beta receptor 2 isoform c precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform 1.

Source sequence(s)

AC152503

Consensus CDS

CCDS84262.1

UniProtKB/TrEMBL

Q923Z6, Q9CS01

Related

ENSMUSP00000086443.7, ENSMUST00000089042.7
NM_010509.2 → NP_034639.2 interferon alpha/beta receptor 2 isoform a precursor

See identical proteins and their annotated locations for NP_034639.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC152503, AK139169, AK153317, AV351897, BE691178, BX515017

Consensus CDS

CCDS28325.1

UniProtKB/Swiss-Prot

O35238, O35663, O35664, O35983, Q923Z5

UniProtKB/TrEMBL

Q3UCC3

Related

ENSMUSP00000023693.8, ENSMUST00000023693.14

Conserved Domains (2) summary

pfam09294
Location:132 → 228

Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

cl21522
Location:42 → 107

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

91166517..91202477

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159790.1 → XP_036015683.1 interferon alpha/beta receptor 2 isoform X4

UniProtKB/TrEMBL

Q9CS01

Conserved Domains (2) summary

pfam09294
Location:132 → 228

Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

cl21522
Location:16 → 107

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_036159789.1 → XP_036015682.1 interferon alpha/beta receptor 2 isoform X3

UniProtKB/TrEMBL

Q9CS01

Conserved Domains (2) summary

pfam09294
Location:132 → 228

Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

cl21522
Location:16 → 107

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_011246100.4 → XP_011244402.1 interferon alpha/beta receptor 2 isoform X1

UniProtKB/TrEMBL

Q3UCC3

Conserved Domains (1) summary

pfam09294
Location:30 → 126

Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
XM_036159788.1 → XP_036015681.1 interferon alpha/beta receptor 2 isoform X2

UniProtKB/TrEMBL

Q8VHN0