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    Dpp8 dipeptidylpeptidase 8 [ Mus musculus (house mouse) ]

    Gene ID: 74388, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dpp8provided by MGI
    Official Full Name
    dipeptidylpeptidase 8provided by MGI
    Primary source
    MGI:MGI:1921638
    See related
    Ensembl:ENSMUSG00000032393 AllianceGenome:MGI:1921638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DP8; DPP VIII; 2310004I03Rik; 4932434F09Rik
    Summary
    Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in negative regulation of programmed cell death and proteolysis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; immune system; limb mesenchyme; metanephros; and skin. Orthologous to human DPP8 (dipeptidyl peptidase 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 15.6), cerebellum adult (RPKM 15.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dpp8 in Genome Data Viewer
    Location:
    9 C; 9 35.06 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64939688..64991785)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65032406..65084503)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene 3-hydroxyacyl-CoA dehydratase 3 Neighboring gene STARR-positive B cell enhancer ABC_E9330 Neighboring gene predicted gene, 39362 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24441 Neighboring gene immunoglobulin superfamily, DCC subclass, member 4 Neighboring gene immunoglobulin superfamily, DCC subclass, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation. Han R, et al. Sci Rep, 2015 Aug 5. PMID 26242871, Free PMC Article
    2. The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease. Buljevic S, et al. J Cell Biochem, 2018 Aug. PMID 29693275
    3. Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome. Okondo MC, et al. Cell Chem Biol, 2018 Mar 15. PMID 29396289, Free PMC Article
    4. The in vivo expression of dipeptidyl peptidases 8 and 9. Yu DM, et al. J Histochem Cytochem, 2009 Nov. PMID 19581630, Free PMC Article
    5. DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages. de Vasconcelos NM, et al. Life Sci Alliance, 2019 Feb. PMID 30718379, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease.
      Title: The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease.
    2. Blocking the expression or activities of DPP8 and DPP9 attenuates PPARgamma2 induction during preadipocyte differentiation.
      Title: Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation.
    3. Suggest roles for DPP8 and DPP9 in lymphocyte activation and apoptosis and in hepatocytes during liver disease pathogenesis.
      Title: Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver.
    4. DP8 and DP9 tissue and cellular expression
      Title: The in vivo expression of dipeptidyl peptidases 8 and 9.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dipeptidyl-peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dipeptidyl peptidase 8
    Names
    dipeptidyl peptidase VIII
    NP_001388065.1
    NP_083182.2
    XP_006511580.1
    XP_030100547.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401136.1 → NP_001388065.1  dipeptidyl peptidase 8

      Status: VALIDATED

      Source sequence(s)
      AC122463
      UniProtKB/Swiss-Prot
      Q80YA7, Q9D4G6
      Related
      ENSMUSP00000126065.2, ENSMUST00000167773.2

    2. NM_028906.3 → NP_083182.2  dipeptidyl peptidase 8

      See identical proteins and their annotated locations for NP_083182.2

      Status: VALIDATED

      Source sequence(s)
      AC122463
      Consensus CDS
      CCDS23285.1
      UniProtKB/Swiss-Prot
      Q80YA7, Q9D4G6
      Related
      ENSMUSP00000034960.7, ENSMUST00000034960.14
      Conserved Domains (2) summary
      pfam00326
      Location:680 → 885
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:169 → 589
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      64939688..64991785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511517.5 → XP_006511580.1  dipeptidyl peptidase 8 isoform X2

      Conserved Domains (2) summary
      pfam00326
      Location:671 → 876
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:160 → 579
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    2. XM_030244687.2 → XP_030100547.1  dipeptidyl peptidase 8 isoform X3

      Conserved Domains (2) summary
      pfam00326
      Location:267 → 472
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:11 → 175
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RNA

    1. XR_003948041.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80YA7.1 GenPept UniProtKB/Swiss-Prot:Q80YA7

    Gene LinkOut

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