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    rpa1 replication protein A1 [ Danio rerio (zebrafish) ]

    Gene ID: 327491, updated on 12-Sep-2024

    Summary

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    Official Symbol
    rpa1provided by ZNC
    Official Full Name
    replication protein A1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030912-3
    See related
    Ensembl:ENSDARG00000003938 AllianceGenome:ZFIN:ZDB-GENE-030912-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55337; zgc:77092; wu:fi14b08
    Summary
    Predicted to enable damaged DNA binding activity and single-stranded telomeric DNA binding activity. Acts upstream of or within heart development. Predicted to be located in nucleus. Predicted to be part of DNA replication factor A complex. Is expressed in head and pectoral fin. Orthologous to human RPA1 (replication protein A1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See rpa1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (26498339..26538989, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (26565463..26606113, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene diphthamide biosynthesis 1 Neighboring gene reticulon 4 receptor-like 1b Neighboring gene uncharacterized LOC137487755 Neighboring gene serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b Neighboring gene WD repeat domain 81

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of zebrafish Rad52 and replication protein A for oligonucleotide-mediated mutagenesis. Takahashi N, et al. Nucleic Acids Res, 2005 Aug 1. PMID 16061934, Free PMC Article
    2. Ionizing radiation induces transgenerational effects of DNA methylation in zebrafish. Kamstra JH, et al. Sci Rep, 2018 Oct 18. PMID 30337673, Free PMC Article
    3. Distinct roles of Shh and Fgf signaling in regulating cell proliferation during zebrafish pectoral fin development. Prykhozhij SV, et al. BMC Dev Biol, 2008 Sep 23. PMID 18811955, Free PMC Article
    4. Knock-In Strategy for Editing Human and Zebrafish Mitochondrial DNA Using Mito-CRISPR/Cas9 System. Bian WP, et al. ACS Synth Biol, 2019 Apr 19. PMID 30955321
    5. Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization. Milan DJ, et al. Circulation, 2009 Aug 18. PMID 19652097, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables single-stranded telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA replication factor A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA replication factor A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    replication protein A 70 kDa DNA-binding subunit
    Names
    RF-A protein 1
    RP-A p70
    replication factor A protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199811.2 → NP_956105.2  replication protein A 70 kDa DNA-binding subunit

      See identical proteins and their annotated locations for NP_956105.2

      Status: PROVISIONAL

      Source sequence(s)
      BC066711
      UniProtKB/Swiss-Prot
      Q6NY74
      Related
      ENSDARP00000029067.5, ENSDART00000032880.6
      Conserved Domains (5) summary
      cd04474
      Location:173 → 275
      RPA1_DBD_A; RPA1_DBD_A: A subfamily of OB folds corresponding to the second OB fold, the ssDNA-binding domain (DBD)-A, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
      cd04477
      Location:8 → 102
      RPA1N; RPA1N: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be involved in all ...
      TIGR00617
      Location:3 → 597
      rpa1; replication factor-a protein 1 (rpa1)
      pfam08646
      Location:446 → 591
      Rep_fac-A_C; Replication factor-A C terminal domain
      pfam16900
      Location:292 → 388
      REPA_OB_2; Replication protein A OB domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      26498339..26538989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NY74.1 GenPept UniProtKB/Swiss-Prot:Q6NY74

    Gene LinkOut

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