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    postnb periostin, osteoblast specific factor b [ Danio rerio (zebrafish) ]

    Gene ID: 337176, updated on 10-Nov-2024

    Summary

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    Official Symbol
    postnbprovided by ZNC
    Official Full Name
    periostin, osteoblast specific factor bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9120
    See related
    Ensembl:ENSDARG00000104267 AllianceGenome:ZFIN:ZDB-GENE-030131-9120
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pn; postn; fa99h07; wu:fa99h07; wu:fc70f09; zgc:153873
    Summary
    Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within muscle attachment. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in epidermis; musculature system; myotome; and somite. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human POSTN (periostin). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See postnb in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (32711641..32740635)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (32853555..32882656)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 4b Neighboring gene si:dkey-74i1.3 Neighboring gene spartin b Neighboring gene doublecortin-like kinase 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Differential reparative phenotypes between zebrafish and medaka after cardiac injury. Ito K, et al. Dev Dyn, 2014 Sep. PMID 24947076
    2. Pan-epicardial lineage tracing reveals that epicardium derived cells give rise to myofibroblasts and perivascular cells during zebrafish heart regeneration. González-Rosa JM, et al. Dev Biol, 2012 Oct 15. PMID 22877945
    3. Zebrafish periostin is required for the adhesion of muscle fiber bundles to the myoseptum and for the differentiation of muscle fibers. Kudo H, et al. Dev Biol, 2004 Mar 15. PMID 15013807
    4. Beneficial impacts of neuromuscular electrical stimulation on muscle structure and function in the zebrafish model of Duchenne muscular dystrophy. Kilroy EA, et al. Elife, 2022 Mar 24. PMID 35324428, Free PMC Article
    5. Istaroxime treatment ameliorates calcium dysregulation in a zebrafish model of phospholamban R14del cardiomyopathy. Kamel SM, et al. Nat Commun, 2021 Dec 9. PMID 34887420, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153873

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    periostin, osteoblast specific factor b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077786.1 → NP_001071254.1  periostin, osteoblast specific factor b isoform 1 precursor

      See identical proteins and their annotated locations for NP_001071254.1

      Status: PROVISIONAL

      Source sequence(s)
      BC125907
      UniProtKB/TrEMBL
      A0JMK0
      Related
      ENSDARP00000135751.1, ENSDART00000157854.2
      Conserved Domains (1) summary
      pfam02469
      Location:245 → 367
      Fasciclin; Fasciclin domain

    2. NM_203421.1 → NP_981966.1  periostin, osteoblast specific factor b isoform 2 precursor

      See identical proteins and their annotated locations for NP_981966.1

      Status: PROVISIONAL

      Source sequence(s)
      AB126325
      UniProtKB/TrEMBL
      A0A0R4IWU6, B3DG50, Q75U66
      Related
      ENSDARP00000141296.1, ENSDART00000167515.2
      Conserved Domains (1) summary
      pfam02469
      Location:245 → 367
      Fasciclin; Fasciclin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      32711641..32740635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009291791.4 → XP_009290066.1  periostin, osteoblast specific factor b isoform X1

      UniProtKB/TrEMBL
      A0A0R4IS83, A0A8M3AHK2
      Related
      ENSDARP00000139439.1, ENSDART00000168135.3
      Conserved Domains (1) summary
      pfam02469
      Location:245 → 367
      Fasciclin; Fasciclin domain

    2. XM_009291792.4 → XP_009290067.1  periostin, osteoblast specific factor b isoform X2

      UniProtKB/TrEMBL
      A0A0R4IPF4, A0A8M3B181
      Related
      ENSDARP00000138099.2, ENSDART00000163936.2
      Conserved Domains (1) summary
      pfam02469
      Location:245 → 367
      Fasciclin; Fasciclin domain

    3. XM_068213481.1 → XP_068069582.1  periostin, osteoblast specific factor b isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.