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    usp11 ubiquitin specific peptidase 11 [ Danio rerio (zebrafish) ]

    Gene ID: 568334, updated on 28-Oct-2024

    Summary

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    Official Symbol
    usp11provided by ZNC
    Official Full Name
    ubiquitin specific peptidase 11provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081104-421
    See related
    Ensembl:ENSDARG00000076303 AllianceGenome:ZFIN:ZDB-GENE-081104-421
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-52h10.4
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to act upstream of or within protein deubiquitination and proteolysis. Predicted to be active in nucleus. Orthologous to human USP11 (ubiquitin specific peptidase 11). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See usp11 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (8643853..8683543)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (8605196..8644963)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene activator of basal transcription 1 Neighboring gene glutamate receptor, metabotropic 6a Neighboring gene zgc:86609 Neighboring gene ubiquitously-expressed, prefoldin-like chaperone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11. Vlasschaert C, et al. BMC Evol Biol, 2015 Oct 26. PMID 26503449, Free PMC Article
    2. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 11
    XP_002663119.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      8643853..8683543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002663073.7 → XP_002663119.3  ubiquitin carboxyl-terminal hydrolase 11

      UniProtKB/TrEMBL
      A0A8M1RR50, F1QPF4
      Related
      ENSDARP00000070106.4, ENSDART00000075624.7
      Conserved Domains (6) summary
      COG5560
      Location:15 → 947
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02674
      Location:793 → 946
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:242 → 419
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam06337
      Location:34 → 119
      DUSP; DUSP domain
      pfam14533
      Location:413 → 504
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam14836
      Location:133 → 219
      Ubiquitin_3; Ubiquitin-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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