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    ttk ttk protein kinase [ Danio rerio (zebrafish) ]

    Gene ID: 317763, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ttkprovided by ZNC
    Official Full Name
    ttk protein kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030123-1
    See related
    Ensembl:ENSDARG00000041361 AllianceGenome:ZFIN:ZDB-GENE-030123-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ncp; mps1
    Summary
    Predicted to enable protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in negative regulation of exit from mitosis and tissue regeneration. Acts upstream of or within anatomical structure homeostasis; fin regeneration; and meiotic chromosome segregation. Predicted to be active in kinetochore and nucleus. Is expressed in caudal fin and proliferative region. Orthologous to human TTK (TTK protein kinase). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ttk in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (5110455..5143124, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (5210829..5243498, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene terminal nucleotidyltransferase 5Aa Neighboring gene branched chain keto acid dehydrogenase E1 subunit beta Neighboring gene dynactin 3 (p22) Neighboring gene ELOVL fatty acid elongase 4a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. Poss KD, et al. Genes Dev, 2004 Jul 1. PMID 15231734, Free PMC Article
    2. Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. Poss KD, et al. Development, 2002 Nov. PMID 12399306
    3. MicroRNA-133b Negatively Regulates Zebrafish Single Mauthner-Cell Axon Regeneration through Targeting tppp3 in Vivo. Huang R, et al. Front Mol Neurosci, 2017. PMID 29209165, Free PMC Article
    4. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Jopling C, et al. Nature, 2010 Mar 25. PMID 20336145, Free PMC Article
    5. Hsp47 mediates Cx43-dependent skeletal growth and patterning in the regenerating fin. Bhadra J, et al. Mech Dev, 2015 Nov. PMID 26103547

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the proximal blastema comprises an essential subpopulation of the fin regenerate defined by the induction and function of Mps1
      Title: Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration.
    2. Mps1 is a critical regulator of chromosome number in zebrafish
      Title: Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anatomical structure homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within female meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fin regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic cell cycle checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein kinase Ttk
    Names
    mitotic checkpoint serine/threonine-protein kinase Mps1
    monopolar spindle 1
    monopolar spindle protein 1
    nightcap
    protein nightcap
    NP_778207.1
    XP_005157890.1
    XP_005157891.1
    XP_068069988.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175042.2 → NP_778207.1  dual specificity protein kinase Ttk

      See identical proteins and their annotated locations for NP_778207.1

      Status: PROVISIONAL

      Source sequence(s)
      AF488735
      UniProtKB/Swiss-Prot
      Q7T2A4, Q8AYG3
      Related
      ENSDARP00000121369.1, ENSDART00000131876.2
      Conserved Domains (2) summary
      cd14131
      Location:652 → 917
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
      pfam00069
      Location:656 → 917
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      5110455..5143124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213887.1 → XP_068069988.1  dual specificity protein kinase Ttk isoform X3

    2. XM_005157834.5 → XP_005157891.1  dual specificity protein kinase Ttk isoform X1

      UniProtKB/Swiss-Prot
      Q7T2A4, Q8AYG3
      UniProtKB/TrEMBL
      A0A8M2B447, F1R3H9
      Related
      ENSDARP00000060629.6, ENSDART00000060630.8
      Conserved Domains (2) summary
      cd14131
      Location:651 → 916
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
      pfam00069
      Location:655 → 916
      Pkinase; Protein kinase domain

    3. XM_005157833.5 → XP_005157890.1  dual specificity protein kinase Ttk isoform X2

      UniProtKB/Swiss-Prot
      Q7T2A4, Q8AYG3
      UniProtKB/TrEMBL
      A0A8M2B4P6
      Conserved Domains (2) summary
      cd14131
      Location:652 → 917
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
      pfam00069
      Location:656 → 917
      Pkinase; Protein kinase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8AYG3.2 GenPept UniProtKB/Swiss-Prot:Q8AYG3

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