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    slc6a3 solute carrier family 6 member 3 [ Danio rerio (zebrafish) ]

    Gene ID: 80787, updated on 28-Oct-2024

    Summary

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    Official Symbol
    slc6a3provided by ZNC
    Official Full Name
    solute carrier family 6 member 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010316-1
    See related
    Ensembl:ENSDARG00000004219 AllianceGenome:ZFIN:ZDB-GENE-010316-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    dat
    Summary
    Predicted to enable metal ion binding activity and symporter activity. Predicted to be located in cell projection and membrane. Is expressed in female organism; male organism; and nervous system. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; classic dopamine transporter deficiency syndrome; mild cognitive impairment; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Oct 2024]
    Annotation information
    Annotation category: suggests misassembly
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See slc6a3 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (248239..263658, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (361269..376736, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene neurensin 1 Neighboring gene uncharacterized LOC553446 Neighboring gene lysophosphatidylcholine acyltransferase 1 Neighboring gene uncharacterized LOC101883647

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The influence of acute dopamine transporter inhibition on manic-, depressive-like phenotypes, and brain oxidative status in adult zebrafish. Canzian J, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2024 Apr 20. PMID 38325745
    2. Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo. Holzschuh J, et al. Mech Dev, 2001 Mar. PMID 11231083
    3. Gender differences in zebrafish responses to cocaine withdrawal. López Patiño MA, et al. Physiol Behav, 2008 Sep 3. PMID 18499199, Free PMC Article
    4. Cis-acting elements responsible for dopaminergic neuron-specific expression of zebrafish slc6a3 (dopamine transporter) in vivo are located remote from the transcriptional start site. Bai Q, et al. Neuroscience, 2009 Dec 15. PMID 19755139
    5. Chemogenetic ablation of dopaminergic neurons leads to transient locomotor impairments in zebrafish larvae. Godoy R, et al. J Neurochem, 2015 Oct. PMID 26118896

    See all (152) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The influence of acute dopamine transporter inhibition on manic-, depressive-like phenotypes, and brain oxidative status in adult zebrafish.
      Title: The influence of acute dopamine transporter inhibition on manic-, depressive-like phenotypes, and brain oxidative status in adult zebrafish.
    2. Transgenic zebrafish expressing green fluorescent protein in dopaminergic neurons of the ventral diencephalon.
      Title: Transgenic zebrafish expressing green fluorescent protein in dopaminergic neurons of the ventral diencephalon.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent dopamine transporter
    Names
    dopamine transporter
    solute carrier family 6 (neurotransmitter transporter), member 3
    solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131755.1 → NP_571830.1  sodium-dependent dopamine transporter

      See identical proteins and their annotated locations for NP_571830.1

      Status: PROVISIONAL

      Source sequence(s)
      AF318177
      UniProtKB/TrEMBL
      Q90ZV1
      Related
      ENSDARP00000111850.3, ENSDART00000129303.3
      Conserved Domains (1) summary
      cd11514
      Location:76 → 623
      SLC6sbd_DAT1; Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      248239..263658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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