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    Orc6 origin recognition complex, subunit 6 [ Mus musculus (house mouse) ]

    Gene ID: 56452, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Orc6provided by MGI
    Official Full Name
    origin recognition complex, subunit 6provided by MGI
    Primary source
    MGI:MGI:1929285
    See related
    Ensembl:ENSMUSG00000031697 AllianceGenome:MGI:1929285
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Orc6l; 6720420I10Rik
    Summary
    Predicted to enable DNA binding activity. Acts upstream of or within DNA-templated DNA replication. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in several structures, including brain ventricular layer; early conceptus; jaw; liver lobe; and submandibular gland primordium. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 3. Orthologous to human ORC6 (origin recognition complex subunit 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 33.8), CNS E11.5 (RPKM 28.8) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Orc6 in Genome Data Viewer
    Location:
    8 C3; 8 41.61 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (86026261..86034908)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85299632..85308279)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily C member 19 Neighboring gene STARR-seq mESC enhancer starr_22152 Neighboring gene VPS35 retromer complex component Neighboring gene STARR-positive B cell enhancer ABC_E9120 Neighboring gene predicted gene, 22336 Neighboring gene myosin light chain kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Recruitment of Orc6l, a dormant maternal mRNA in mouse oocytes, is essential for DNA replication in 1-cell embryos. Murai S, et al. Dev Biol, 2010 May 1. PMID 20219456, Free PMC Article
    2. The dynamic nature of the human origin recognition complex revealed through five cryoEM structures. Jaremko MJ, et al. Elife, 2020 Aug 18. PMID 32808929, Free PMC Article
    3. Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. Kneissl M, et al. J Mol Biol, 2003 Mar 14. PMID 12614612
    4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study reports that ORC6L is another component required for acquisition of DNA replication competence that is absent in mouse oocytes.
      Title: Recruitment of Orc6l, a dormant maternal mRNA in mouse oocytes, is essential for DNA replication in 1-cell embryos.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91038

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA-templated DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear origin of replication recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear origin of replication recognition complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of origin recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    origin recognition complex subunit 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163791.1 → NP_001157263.1  origin recognition complex subunit 6 isoform b

      See identical proteins and their annotated locations for NP_001157263.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC134854, AK078405, AK163256, BF661105, BP771997
      Consensus CDS
      CCDS52623.1
      UniProtKB/TrEMBL
      Q3TQX1
      Related
      ENSMUSP00000126925.2, ENSMUST00000170141.3
      Conserved Domains (2) summary
      cd11583
      Location:18 → 110
      Orc6_mid; Middle domain of the origin recognition complex subunit 6
      cd16075
      Location:135 → 183
      ORC6_CTD; C-terminal domain of the eukaryotic origin recognition complex subunit ORC6

    2. NM_019716.2 → NP_062690.2  origin recognition complex subunit 6 isoform a

      See identical proteins and their annotated locations for NP_062690.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC134854, AK078405, AK163256, BC080739, BF661105, BP771997
      Consensus CDS
      CCDS22497.1
      UniProtKB/Swiss-Prot
      Q9WUJ8
      UniProtKB/TrEMBL
      Q66JV6
      Related
      ENSMUSP00000034132.6, ENSMUST00000034132.13
      Conserved Domains (3) summary
      cd11583
      Location:94 → 186
      Orc6_mid; Middle domain of the origin recognition complex subunit 6
      pfam05460
      Location:6 → 94
      ORC6; Origin recognition complex subunit 6 (ORC6)
      cd16075
      Location:211 → 259
      ORC6_CTD; C-terminal domain of the eukaryotic origin recognition complex subunit ORC6

    RNA

    1. NR_028268.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC134854, AK078405, AK163256, BC080739, BF661105, BP771997

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      86026261..86034908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUJ8.1 GenPept UniProtKB/Swiss-Prot:Q9WUJ8

    Gene LinkOut

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