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    P5CDh2 delta-1-Pyrroline-5-carboxylate dehydrogenase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32625, updated on 2-Nov-2024

    Summary

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    Official Symbol
    P5CDh2provided by FlyBase
    Official Full Name
    delta-1-Pyrroline-5-carboxylate dehydrogenase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0053092
    Locus tag
    Dmel_CG33092
    See related
    AllianceGenome:FB:FBgn0053092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33092; CG6670; Dmel\CG33092; DmP5CDh2
    Summary
    Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See P5CDh2 in Genome Data Viewer
    Location:
    93F14-93F14; 3-73 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21877936..21880696)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17703658..17706418)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45046 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene female-specific independent of transformer Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDh) is required for proline breakdown and mitochondrial integrity-Establishing a fly model for human type II hyperprolinemia. He F, et al. Mitochondrion, 2011 May. PMID 21168532
    2. Sequences, phylogeny and evolution of mitochondrial delta-1-pyrroline-5-carboxylate dehydrogenases (ALDH4A1). Evidence for a second locus (ALDH4A2) in Drosophila. Holmes RS. Chem Biol Interact, 2023 Sep 25. PMID 37597643
    3. Enteric bacterial infection in Drosophila induces whole-body alterations in metabolic gene expression independently of the immune deficiency signaling pathway. Deshpande R, et al. G3 (Bethesda), 2022 Nov 4. PMID 35781508, Free PMC Article
    4. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article
    5. Protein interaction mapping: a Drosophila case study. Formstecher E, et al. Genome Res, 2005 Mar. PMID 15710747, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sequences, phylogeny and evolution of mitochondrial delta-1-pyrroline-5-carboxylate dehydrogenases (ALDH4A1). Evidence for a second locus (ALDH4A2) in Drosophila.
      Title: Sequences, phylogeny and evolution of mitochondrial delta-1-pyrroline-5-carboxylate dehydrogenases (ALDH4A1). Evidence for a second locus (ALDH4A2) in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-pyrroline-5-carboxylate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-pyrroline-5-carboxylate dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proline catabolic process to glutamate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    delta-1-Pyrroline-5-carboxylate dehydrogenase 2
    Names
    CG33092-PA
    CG33092-PB
    CG33092-PC
    CG33092-PD
    CG33092-PE
    CG33092-PG
    P5CDh2-PA
    P5CDh2-PB
    P5CDh2-PC
    P5CDh2-PD
    P5CDh2-PE
    P5CDh2-PG
    NP_788705.1
    NP_788706.1
    NP_788707.1
    NP_788709.1
    NP_788710.1
    NP_788711.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21877936..21880696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176528.2 → NP_788705.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788705.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDM6, Q8T0Q8, Q9VD67
      Conserved Domains (1) summary
      cl11961
      Location:50 → 570
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily

    2. NM_176533.1 → NP_788710.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788710.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDM6, Q8IN18
      Conserved Domains (1) summary
      cl11961
      Location:45 → 565
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily

    3. NM_176534.1 → NP_788711.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788711.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDM6, Q8IN17
      Conserved Domains (1) summary
      cl11961
      Location:44 → 564
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily

    4. NM_176530.1 → NP_788707.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788707.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDM6, Q8T0Q8, Q9VD67
      Conserved Domains (1) summary
      cl11961
      Location:50 → 570
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily

    5. NM_176532.1 → NP_788709.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788709.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDM6, Q8IN18
      Conserved Domains (1) summary
      cl11961
      Location:45 → 565
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily

    6. NM_176529.1 → NP_788706.1  delta-1-Pyrroline-5-carboxylate dehydrogenase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788706.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDM6, Q8T0Q8, Q9VD67
      Conserved Domains (1) summary
      cl11961
      Location:50 → 570
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IN17 Q8IN17
    Q8IN18 Q8IN18
    Q8T0Q8 Q8T0Q8

    Gene LinkOut

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