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    Itprid2 ITPR interacting domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 70599, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Itprid2provided by MGI
    Official Full Name
    ITPR interacting domain containing 2provided by MGI
    Primary source
    MGI:MGI:1917849
    See related
    Ensembl:ENSMUSG00000027007 AllianceGenome:MGI:1917849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CS1; CS-1; KRAP; Ssfa2; SPAG13; mKIAA1927; 5730488C15Rik
    Summary
    Predicted to enable actin filament binding activity. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Orthologous to human ITPRID2 (ITPR interacting domain containing 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 10.2), small intestine adult (RPKM 10.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Itprid2 in Genome Data Viewer
    Location:
    2 C3; 2 47.58 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (79419207..79503310)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (79588863..79672966)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54165 Neighboring gene predicted gene, 39867 Neighboring gene STARR-positive B cell enhancer ABC_E2625 Neighboring gene STARR-seq mESC enhancer starr_04937 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 1C Neighboring gene STARR-seq mESC enhancer starr_04938 Neighboring gene STARR-seq mESC enhancer starr_04939 Neighboring gene phosphodiesterase 1A, calmodulin-dependent Neighboring gene predicted gene, 54166

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice. Fujimoto T, et al. PLoS One, 2009. PMID 19156225, Free PMC Article
    2. Pancreatic hypertrophy in Ki-ras-induced actin-interacting protein gene knockout mice. Miyasaka K, et al. Pancreas, 2011 Jan. PMID 21160370
    3. KRAS-induced actin-interacting protein: a potent target for obesity, diabetes and cancer. Fujimoto T, et al. Anticancer Res, 2011 Jul. PMID 21873152
    4. KRAS-induced actin-interacting protein is required for the proper localization of inositol 1,4,5-trisphosphate receptor in the epithelial cells. Fujimoto T, et al. Biochem Biophys Res Commun, 2011 Apr 8. PMID 21420385
    5. Deregulated expression of KRAP, a novel gene encoding actin-interacting protein, in human colon cancer cells. Inokuchi J, et al. J Hum Genet, 2004. PMID 14673706

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KRAP physically associates with IP3 receptors and regulates their proper localization in the mucous cells and the chief cells of the stomach and in the proximal tubular cells of the kidneys.
      Title: Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney.
    2. KRAP-deficient mice show altered whole-body energy metabolism & resistance to diet-induced obesity and diabetes. Review.
      Title: KRAS-induced actin-interacting protein: a potent target for obesity, diabetes and cancer.
    3. KRAP is involved in the proper regulation of IP3R-mediated Ca2+ release.
      Title: KRAS-induced actin-interacting protein regulates inositol 1,4,5-trisphosphate-receptor-mediated calcium release.
    4. These findings demonstrate that KRAP physically associates with IP(3)R and regulates the proper localization of IP(3)R in the epithelial cells in vivo and cultured cells.
      Title: KRAS-induced actin-interacting protein is required for the proper localization of inositol 1,4,5-trisphosphate receptor in the epithelial cells.
    5. The lack and/or decrease in Ki-ras-induced actin-interacting protein level in the pancreas may promote the pancreatic growth and hypertrophy.
      Title: Pancreatic hypertrophy in Ki-ras-induced actin-interacting protein gene knockout mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein ITPRID2
    Names
    ITPR-interacting domain-containing protein 2
    ki-ras-induced actin-interacting protein
    sperm specific antigen 2
    sperm-specific antigen 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080558.4 → NP_542125.3  protein ITPRID2

      See identical proteins and their annotated locations for NP_542125.3

      Status: VALIDATED

      Source sequence(s)
      BC079535, CF539296, CJ129385
      Consensus CDS
      CCDS16170.1
      UniProtKB/Swiss-Prot
      A2AQD4, A5D8Z6, Q08E80, Q14BJ9, Q544I3, Q68FN1, Q75WU7, Q8CH96, Q8VEF7, Q922B9
      UniProtKB/TrEMBL
      A2AQD6
      Related
      ENSMUSP00000107415.3, ENSMUST00000111785.9
      Conserved Domains (2) summary
      pfam14722
      Location:146 → 297
      KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
      pfam14723
      Location:861 → 1029
      SSFA2_C; Sperm-specific antigen 2 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      79419207..79503310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162564.1 → XP_036018457.1  protein ITPRID2 isoform X1

      UniProtKB/Swiss-Prot
      A2AQD4, A5D8Z6, Q08E80, Q14BJ9, Q544I3, Q68FN1, Q75WU7, Q8CH96, Q8VEF7, Q922B9
      UniProtKB/TrEMBL
      A2AQD6
      Conserved Domains (2) summary
      pfam14722
      Location:146 → 297
      KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
      pfam14723
      Location:861 → 1029
      SSFA2_C; Sperm-specific antigen 2 C-terminus

    2. XM_036162565.1 → XP_036018458.1  protein ITPRID2 isoform X2

      UniProtKB/TrEMBL
      A2AQD5, A2AQD6
      Related
      ENSMUSP00000107414.3, ENSMUST00000111784.9
      Conserved Domains (2) summary
      pfam14722
      Location:146 → 297
      KRAP_IP3R_bind; Ki-ras-induced actin-interacting protein-IP3R-interacting domain
      pfam14723
      Location:861 → 1029
      SSFA2_C; Sperm-specific antigen 2 C-terminus

    3. XM_006500165.4 → XP_006500228.1  protein ITPRID2 isoform X3

      Conserved Domains (1) summary
      pfam14723
      Location:373 → 539
      SSFA2_C; Sperm-specific antigen 2 C-terminus

    RNA

    1. XR_001783177.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922B9.3 GenPept UniProtKB/Swiss-Prot:Q922B9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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