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    Inca1 inhibitor of CDK, cyclin A1 interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 103844, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Inca1provided by MGI
    Official Full Name
    inhibitor of CDK, cyclin A1 interacting protein 1provided by MGI
    Primary source
    MGI:MGI:2144284
    See related
    Ensembl:ENSMUSG00000057054 AllianceGenome:MGI:2144284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables cyclin binding activity. Acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of fibroblast proliferation; and positive regulation of apoptotic signaling pathway. Predicted to be located in nuclear body. Predicted to be active in cytoplasm. Is expressed in female reproductive system; germ cell of ovary; mesenchymal stroma of ovary; and ovary. Orthologous to human INCA1 (inhibitor of CDK, cyclin A1 interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver adult (RPKM 8.3), testis adult (RPKM 7.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Inca1 in Genome Data Viewer
    Location:
    11 B3; 11 43.21 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70579187..70593177, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70688361..70700285, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E62 Neighboring gene sperm associated antigen 7 Neighboring gene calmodulin binding transcription activator 2 Neighboring gene STARR-positive B cell enhancer ABC_E7009 Neighboring gene kinesin family member 1C Neighboring gene microRNA 6925 Neighboring gene predicted gene 12320

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Maintenance of leukemia-initiating cells is regulated by the CDK inhibitor Inca1. Bäumer N, et al. PLoS One, 2014. PMID 25525809, Free PMC Article
    2. Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. Bäumer N, et al. J Biol Chem, 2011 Aug 12. PMID 21540187, Free PMC Article
    3. The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects. Zhang F, et al. PLoS One, 2011. PMID 21750715, Free PMC Article
    4. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. Diederichs S, et al. J Biol Chem, 2004 Aug 6. PMID 15159402
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of fibroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of fibroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein INCA1
    Names
    inhibitor of CDK interacting with cyclin A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252482.2 → NP_001239411.1  protein INCA1 isoform 1

      See identical proteins and their annotated locations for NP_001239411.1

      Status: VALIDATED

      Source sequence(s)
      AL596117
      Consensus CDS
      CCDS24964.1
      UniProtKB/Swiss-Prot
      Q4VAE2, Q6PKN7
      Related
      ENSMUSP00000118761.3, ENSMUST00000126114.9
      Conserved Domains (1) summary
      pfam15142
      Location:12 → 187
      INCA1

    2. NM_001252483.2 → NP_001239412.1  protein INCA1 isoform 1

      See identical proteins and their annotated locations for NP_001239412.1

      Status: VALIDATED

      Source sequence(s)
      AL596117
      Consensus CDS
      CCDS24964.1
      UniProtKB/Swiss-Prot
      Q4VAE2, Q6PKN7
      Related
      ENSMUSP00000104181.3, ENSMUST00000108541.9
      Conserved Domains (1) summary
      pfam15142
      Location:12 → 187
      INCA1

    3. NM_001252484.2 → NP_001239413.1  protein INCA1 isoform 1

      See identical proteins and their annotated locations for NP_001239413.1

      Status: VALIDATED

      Source sequence(s)
      AL596117
      Consensus CDS
      CCDS24964.1
      UniProtKB/Swiss-Prot
      Q4VAE2, Q6PKN7
      Related
      ENSMUSP00000104182.2, ENSMUST00000108542.8
      Conserved Domains (1) summary
      pfam15142
      Location:12 → 187
      INCA1

    4. NM_001252485.2 → NP_001239414.1  protein INCA1 isoform 2

      See identical proteins and their annotated locations for NP_001239414.1

      Status: VALIDATED

      Source sequence(s)
      AL596117
      Consensus CDS
      CCDS56789.1
      UniProtKB/Swiss-Prot
      Q6PKN7
      Related
      ENSMUSP00000104183.4, ENSMUST00000108543.4
      Conserved Domains (1) summary
      pfam15142
      Location:1 → 152
      INCA1

    5. NM_001419090.1 → NP_001406019.1  protein INCA1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596117
      UniProtKB/Swiss-Prot
      Q4VAE2, Q6PKN7

    6. NM_001419091.1 → NP_001406020.1  protein INCA1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596117
      UniProtKB/Swiss-Prot
      Q4VAE2, Q6PKN7

    7. NM_001419092.1 → NP_001406021.1  protein INCA1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596117
      UniProtKB/Swiss-Prot
      Q4VAE2, Q6PKN7

    8. NM_001419093.1 → NP_001406022.1  protein INCA1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596117
      UniProtKB/Swiss-Prot
      Q4VAE2, Q6PKN7

    9. NM_001419094.1 → NP_001406023.1  protein INCA1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596117

    10. NM_001419095.1 → NP_001406024.1  protein INCA1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596117

    11. NM_001419096.1 → NP_001406025.1  protein INCA1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596117

    12. NM_001419097.1 → NP_001406026.1  protein INCA1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596117

    13. NM_213729.2 → NP_998894.1  protein INCA1 isoform 1

      See identical proteins and their annotated locations for NP_998894.1

      Status: VALIDATED

      Source sequence(s)
      AL596117
      Consensus CDS
      CCDS24964.1
      UniProtKB/Swiss-Prot
      Q4VAE2, Q6PKN7
      Related
      ENSMUSP00000073311.2, ENSMUST00000073625.8
      Conserved Domains (1) summary
      pfam15142
      Location:12 → 187
      INCA1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70579187..70593177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156197.1 → XP_036012090.1  protein INCA1 isoform X2

      Conserved Domains (1) summary
      pfam15142
      Location:1 → 152
      INCA1

    2. XM_036156195.1 → XP_036012088.1  protein INCA1 isoform X2

      Conserved Domains (1) summary
      pfam15142
      Location:1 → 152
      INCA1

    3. XM_036156198.1 → XP_036012091.1  protein INCA1 isoform X3

      Conserved Domains (1) summary
      pfam15142
      Location:12 → 109
      INCA1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PKN7.1 GenPept UniProtKB/Swiss-Prot:Q6PKN7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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