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    Thap3 THAP domain containing, apoptosis associated protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 69876, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Thap3provided by MGI
    Official Full Name
    THAP domain containing, apoptosis associated protein 3provided by MGI
    Primary source
    MGI:MGI:1917126
    See related
    Ensembl:ENSMUSG00000039759 AllianceGenome:MGI:1917126
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010013E08Rik; 2210418H06Rik
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Is expressed in central nervous system and genitourinary system. Orthologous to human THAP3 (THAP domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 23.1), adrenal adult (RPKM 20.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Thap3 in Genome Data Viewer
    Location:
    4 E2; 4 82.8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152067095..152073443, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (151982638..151988986, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene calmodulin binding transcription activator 1 Neighboring gene RIKEN cDNA 9230110K08 gene Neighboring gene STARR-positive B cell enhancer ABC_E30 Neighboring gene predicted gene, 42357 Neighboring gene STARR-positive B cell enhancer ABC_E6290 Neighboring gene STARR-positive B cell enhancer ABC_E3557 Neighboring gene DnaJ heat shock protein family (Hsp40) member C11 Neighboring gene kelch-like 21 Neighboring gene PHD finger protein 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Global gene expression analysis of murine limb development. Taher L, et al. PLoS One, 2011. PMID 22174793, Free PMC Article
    2. RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse. Hüttenhofer A, et al. EMBO J, 2001 Jun 1. PMID 11387227, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    THAP domain-containing protein 3
    Names
    snoRNA MBI-15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145929.1 → NP_001139401.1  THAP domain-containing protein 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL611931, BC059091, BY013572
      Consensus CDS
      CCDS51387.1
      UniProtKB/TrEMBL
      A2A8D4
      Related
      ENSMUSP00000101290.3, ENSMUST00000105665.3
      Conserved Domains (1) summary
      pfam05485
      Location:4 → 82
      THAP; THAP domain

    2. NM_175152.4 → NP_780361.2  THAP domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_780361.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC059091, BC094395, BY013572
      Consensus CDS
      CCDS18982.1
      UniProtKB/Swiss-Prot
      Q8BII6, Q8BJ25
      UniProtKB/TrEMBL
      Q52KE1
      Related
      ENSMUSP00000035240.2, ENSMUST00000036680.8
      Conserved Domains (1) summary
      pfam05485
      Location:4 → 82
      THAP; THAP domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      152067095..152073443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJ25.1 GenPept UniProtKB/Swiss-Prot:Q8BJ25

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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