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    Rrp8 ribosomal RNA processing 8 [ Mus musculus (house mouse) ]

    Gene ID: 101867, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rrp8provided by MGI
    Official Full Name
    ribosomal RNA processing 8provided by MGI
    Primary source
    MGI:MGI:1914251
    See related
    Ensembl:ENSMUSG00000030888 AllianceGenome:MGI:1914251
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NML; 1500003O22Rik; 2900001K19Rik
    Summary
    Predicted to enable methylated histone binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of gene expression. Predicted to act upstream of with a negative effect on regulation of G1 to G0 transition. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and rDNA heterochromatin. Predicted to be part of eNoSc complex. Predicted to be active in nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human RRP8 (ribosomal RNA processing 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.5), bladder adult (RPKM 9.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rrp8 in Genome Data Viewer
    Location:
    7 E3; 7 55.97 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105380937..105386592, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (105731730..105737385, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 10B Neighboring gene predicted gene, 22504 Neighboring gene dynein heavy chain domain 1 Neighboring gene mitochondrial ribosomal protein S36, pseudogene 2 Neighboring gene STARR-positive B cell enhancer mm9_chr7:112892770-112893071 Neighboring gene STARR-positive B cell enhancer mm9_chr7:112900636-112900937 Neighboring gene integrin linked kinase Neighboring gene TATA-box binding protein associated factor 10 Neighboring gene tripeptidyl peptidase I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hepatic rRNA transcription regulates high-fat-diet-induced obesity. Oie S, et al. Cell Rep, 2014 May 8. PMID 24746822
    2. Nucleomethylin deficiency impairs embryonic erythropoiesis. Murakami S, et al. J Biochem, 2018 May 1. PMID 29244083
    3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rDNA heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rDNA heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rDNA heterochromatin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_negative_effect regulation of G1 to G0 transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by glucose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by glucose ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin silencing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin silencing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin silencing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eNoSc complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in rDNA heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in rDNA heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in rDNA heterochromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal RNA-processing protein 8
    Names
    cerebral protein 1 homolog
    nucleomethylin protein
    ribosomal RNA processing 8, methyltransferase, homolog
    NP_080173.1
    NP_598712.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025897.2 → NP_080173.1  ribosomal RNA-processing protein 8 isoform 2

      See identical proteins and their annotated locations for NP_080173.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC121823, AK005138, AV460242
      Consensus CDS
      CCDS21658.1
      UniProtKB/Swiss-Prot
      Q3T9X9, Q3TDD7, Q3U3A5, Q8BHW3, Q9DB85
      UniProtKB/TrEMBL
      Q3U4B0
      Related
      ENSMUSP00000033179.7, ENSMUST00000033179.14
      Conserved Domains (1) summary
      pfam05148
      Location:243 → 457
      Methyltransf_8; Hypothetical methyltransferase

    2. NM_133951.1 → NP_598712.1  ribosomal RNA-processing protein 8 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC121823
      Consensus CDS
      CCDS57576.1
      UniProtKB/TrEMBL
      E9PVA2, Q3U4B0
      Related
      ENSMUSP00000095752.5, ENSMUST00000098148.6
      Conserved Domains (1) summary
      pfam05148
      Location:289 → 503
      Methyltransf_8; Hypothetical methyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      105380937..105386592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_378204.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DB85.1 GenPept UniProtKB/Swiss-Prot:Q9DB85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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