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    Pde4b phosphodiesterase 4B, cAMP specific [ Mus musculus (house mouse) ]

    Gene ID: 18578, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pde4bprovided by MGI
    Official Full Name
    phosphodiesterase 4B, cAMP specificprovided by MGI
    Primary source
    MGI:MGI:99557
    See related
    Ensembl:ENSMUSG00000028525 AllianceGenome:MGI:99557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dpde4; dunce
    Summary
    Enables gamma-tubulin binding activity. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and neutrophil homeostasis. Located in several cellular components, including centrosome; postsynaptic density; and synaptic vesicle. Part of gamma-tubulin complex. Is expressed in several structures, including alimentary system; ear; genitourinary system; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human PDE4B (phosphodiesterase 4B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 9.7), frontal lobe adult (RPKM 9.3) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pde4b in Genome Data Viewer
    Location:
    4 C6; 4 46.99 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (101944529..102464459)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (102087332..102607275)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10922 Neighboring gene STARR-seq mESC enhancer starr_10923 Neighboring gene PRAME like 62 Neighboring gene STARR-seq mESC enhancer starr_10924 Neighboring gene RNA binding motif protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10925 Neighboring gene predicted gene, 52669 Neighboring gene zinc finger protein 352 pseudogene Neighboring gene zinc finger protein 352 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10926 Neighboring gene STARR-positive B cell enhancer ABC_E3498 Neighboring gene STARR-positive B cell enhancer mm9_chr4:102178342-102178642 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:102184116-102184299 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:102184409-102184518 Neighboring gene STARR-positive B cell enhancer ABC_E4639 Neighboring gene STARR-positive B cell enhancer ABC_E1034 Neighboring gene predicted gene, 52668 Neighboring gene STARR-seq mESC enhancer starr_10927 Neighboring gene predicted gene, 52667 Neighboring gene predicted gene, 24869 Neighboring gene STARR-seq mESC enhancer starr_10929 Neighboring gene SH3-domain GRB2-like (endophilin) interacting protein 1 Neighboring gene predicted gene 12709

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme. Siuciak JA, et al. Psychopharmacology (Berl), 2007 Jun. PMID 17333137
    2. Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation. Avila DV, et al. Neuropharmacology, 2017 Oct. PMID 28807677, Free PMC Article
    3. Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus. Campbell SL, et al. BMC Neurosci, 2017 Dec 2. PMID 29197324, Free PMC Article
    4. Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia. Myers SA, et al. Neurobiol Dis, 2019 Apr. PMID 30557659, Free PMC Article
    5. Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis. Avila DV, et al. J Pathol, 2016 Sep. PMID 27287961, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDE4B Missense Variant Increases Susceptibility to Post-traumatic Stress Disorder-Relevant Phenotypes in Mice.
      Title: PDE4B Missense Variant Increases Susceptibility to Post-traumatic Stress Disorder-Relevant Phenotypes in Mice.
    2. Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice.
      Title: Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice.
    3. LncRNA GAS5 Knockdown Mitigates Hepatic Lipid Accumulation via Regulating MiR-26a-5p/PDE4B to Activate cAMP/CREB Pathway.
      Title: LncRNA GAS5 Knockdown Mitigates Hepatic Lipid Accumulation via Regulating MiR-26a-5p/PDE4B to Activate cAMP/CREB Pathway.
    4. Declines in PDE4B activity promote myopia progression through downregulation of scleral collagen expression.
      Title: Declines in PDE4B activity promote myopia progression through downregulation of scleral collagen expression.
    5. Phosphodiesterase 4B is required for NLRP3 inflammasome activation by positive feedback with Nrf2 in the early phase of LPS- induced acute lung injury.
      Title: Phosphodiesterase 4B is required for NLRP3 inflammasome activation by positive feedback with Nrf2 in the early phase of LPS- induced acute lung injury.
    6. Evidence for reprogramming of monocytes into reparative alveolar macrophages in vivo by targeting PDE4b.
      Title: Evidence for reprogramming of monocytes into reparative alveolar macrophages in vivo by targeting PDE4b.
    7. circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.
      Title: circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.
    8. Ablation of PDE4B protects from Pseudomonas aeruginosa-induced acute lung injury in mice by ameliorating the cytostorm and associated hypothermia.
      Title: Ablation of PDE4B protects from Pseudomonas aeruginosa-induced acute lung injury in mice by ameliorating the cytostorm and associated hypothermia.
    9. Selective Inhibition of PDE4B Reduces Binge Drinking in Two C57BL/6 Substrains.
      Title: Selective Inhibition of PDE4B Reduces Binge Drinking in Two C57BL/6 Substrains.
    10. these findings indicate that PDE4B plays an important role in the development of acute and chronic inflammatory response and consequent recovery following spinal cord injury
      Title: Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables gamma-tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within leukocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neutrophil homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in excitatory synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of gamma-tubulin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3',5'-cyclic-AMP phosphodiesterase 4B
    NP_001171451.1
    NP_001171452.1
    NP_001171453.1
    NP_001171454.1
    NP_001361709.1
    NP_001391715.1
    NP_001391716.1
    NP_001391717.1
    NP_001391718.1
    NP_001391720.1
    NP_001391722.1
    NP_001391723.1
    NP_001391725.1
    NP_001391733.1
    NP_001391765.1
    NP_062814.2
    XP_006502919.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177980.2 → NP_001171451.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 5' exons but has an alternate 5' segment, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
      Source sequence(s)
      AL732551, AL772358
      Consensus CDS
      CCDS51243.1
      UniProtKB/TrEMBL
      B1AWD0, Q91VY2
      Related
      ENSMUSP00000095562.3, ENSMUST00000097950.9
      Conserved Domains (1) summary
      pfam00233
      Location:233 → 474
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. NM_001177981.1 → NP_001171452.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 3

      See identical proteins and their annotated locations for NP_001171452.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (3) is shorter and has a different N-terminus, as compared to isoform 1.
      Source sequence(s)
      AL732551, BB654856, BC071259
      Consensus CDS
      CCDS51244.1
      UniProtKB/TrEMBL
      Q6IQY6, Q91VY2
      Related
      ENSMUSP00000095561.5, ENSMUST00000097949.11
      Conserved Domains (1) summary
      pfam00233
      Location:172 → 413
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. NM_001177982.1 → NP_001171453.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 4

      See identical proteins and their annotated locations for NP_001171453.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks several 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (4) has a much shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK161341, AL732551
      Consensus CDS
      CCDS51245.1
      UniProtKB/TrEMBL
      Q3TTI9, Q91VY2
      Related
      ENSMUSP00000030251.7, ENSMUST00000030251.13
      Conserved Domains (1) summary
      pfam00233
      Location:153 → 394
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    4. NM_001177983.2 → NP_001171454.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 5

      See identical proteins and their annotated locations for NP_001171454.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks several 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (5) is shorter and has a different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AL772293, AL772358
      Consensus CDS
      CCDS57289.1
      UniProtKB/TrEMBL
      Q80VK8
      Related
      ENSMUSP00000102520.3, ENSMUST00000106907.9

    5. NM_001374780.2 → NP_001361709.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772358, AL807794
      Consensus CDS
      CCDS89787.1
      UniProtKB/TrEMBL
      B1AWC8, Q9QXI7
      Related
      ENSMUSP00000102517.3, ENSMUST00000106904.9
      Conserved Domains (2) summary
      pfam00233
      Location:328 → 569
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:89 → 204
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    6. NM_001404786.1 → NP_001391715.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772293, AL772358
      UniProtKB/TrEMBL
      B1AWC9
      Related
      ENSMUSP00000102524.2, ENSMUST00000106911.8

    7. NM_001404787.1 → NP_001391716.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL772293, AL772358

    8. NM_001404788.1 → NP_001391717.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL772293, AL772358

    9. NM_001404789.1 → NP_001391718.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772293, AL772358, AL807794
      UniProtKB/TrEMBL
      B1AWC8

    10. NM_001404791.1 → NP_001391720.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772293, AL772358

    11. NM_001404793.1 → NP_001391722.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772358

    12. NM_001404794.1 → NP_001391723.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772358

    13. NM_001404796.1 → NP_001391725.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772358

    14. NM_001404804.1 → NP_001391733.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772358

    15. NM_001404836.1 → NP_001391765.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 15

      Status: VALIDATED

      Source sequence(s)
      AL732551, AL772358

    16. NM_019840.3 → NP_062814.2  3',5'-cyclic-AMP phosphodiesterase 4B isoform 1

      See identical proteins and their annotated locations for NP_062814.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL732551, AL772293, AL772358
      Consensus CDS
      CCDS18403.1
      UniProtKB/TrEMBL
      Q8VBU5, Q9QXI7
      Related
      ENSMUSP00000102521.3, ENSMUST00000106908.9
      Conserved Domains (1) summary
      pfam00233
      Location:390 → 631
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      101944529..102464459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502856.2 → XP_006502919.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X2

      UniProtKB/TrEMBL
      Q9QXI7
      Conserved Domains (2) summary
      pfam00233
      Location:344 → 585
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam18100
      Location:105 → 220
      PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

    RNA

    1. XR_004941842.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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