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    Cdc42se1 CDC42 small effector 1 [ Mus musculus (house mouse) ]

    Gene ID: 57912, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cdc42se1provided by MGI
    Official Full Name
    CDC42 small effector 1provided by MGI
    Primary source
    MGI:MGI:1889510
    See related
    Ensembl:ENSMUSG00000046722 AllianceGenome:MGI:1889510
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SCIP1; Spec1; Cdcse1; 1300002M12Rik
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in phagocytosis and regulation of Rho protein signal transduction. Predicted to act upstream of or within negative regulation of JNK cascade; regulation of cell shape; and small GTPase-mediated signal transduction. Predicted to be located in cell cortex and cell junction. Predicted to be active in plasma membrane. Is expressed in cerebral cortex and cerebral cortex ventricular layer. Orthologous to human CDC42SE1 (CDC42 small effector 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 34.7), thymus adult (RPKM 34.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdc42se1 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95135735..95143735)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95228424..95236424)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C Neighboring gene GA repeat binding protein, beta 2 Neighboring gene STARR-seq mESC enhancer starr_08372 Neighboring gene predicted gene, 16740 Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene prune exopolyphosphatase Neighboring gene STARR-positive B cell enhancer ABC_E2672 Neighboring gene MINDY lysine 48 deubiquitinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sequential and morphological analyses of aberrant crypt foci formation in mice of differing susceptibility to azoxymethane-induced colon carcinogenesis. Papanikolaou A, et al. Carcinogenesis, 2000 Aug. PMID 10910960
    2. SPECs, small binding proteins for Cdc42. Pirone DM, et al. J Biol Chem, 2000 Jul 28. PMID 10816584
    3. A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development. Hasenpusch-Theil K, et al. Elife, 2020 Aug 25. PMID 32840212, Free PMC Article
    4. Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus. Hasenpusch-Theil K, et al. Cereb Cortex, 2012 Dec. PMID 22235033, Free PMC Article
    5. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within small GTPase-mediated signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CDC42 small effector protein 1
    Names
    small protein effector 1 of Cdc42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038708.3 → NP_001033797.1  CDC42 small effector protein 1

      See identical proteins and their annotated locations for NP_001033797.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK004859, BC060964, CF105339, CJ290563
      Consensus CDS
      CCDS38545.1
      UniProtKB/Swiss-Prot
      Q8BHL7
      Related
      ENSMUSP00000102819.3, ENSMUST00000107201.9
      Conserved Domains (1) summary
      cl00113
      Location:29 → 67
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    2. NM_172395.3 → NP_765983.1  CDC42 small effector protein 1

      See identical proteins and their annotated locations for NP_765983.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK004859, AV456394, CJ290563
      Consensus CDS
      CCDS38545.1
      UniProtKB/Swiss-Prot
      Q8BHL7
      Related
      ENSMUSP00000052986.6, ENSMUST00000053872.12
      Conserved Domains (1) summary
      cl00113
      Location:29 → 67
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95135735..95143735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHL7.1 GenPept UniProtKB/Swiss-Prot:Q8BHL7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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