Rabac1 Rab acceptor 1 (prenylated) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rabac1provided by MGI
Official Full Name: Rab acceptor 1 (prenylated)provided by MGI
Primary source: MGI:MGI:1201692
See related: Ensembl:ENSMUSG00000003380 AllianceGenome:MGI:1201692
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PRA1; Gbpap1; prenylin; 2310040I06Rik
Summary: Predicted to enable GTPase binding activity; identical protein binding activity; and proline-rich region binding activity. Located in Golgi apparatus and membrane. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; integumental system; and nervous system. Orthologous to human RABAC1 (Rab acceptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 327.7), adrenal adult (RPKM 305.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 13.73 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (24669175..24672153, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (24969750..24972728, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Di-arginine and FFAT-like motifs retain a subpopulation of PRA1 at ER-mitochondria membrane contact sites.
Title: Di-arginine and FFAT-like motifs retain a subpopulation of PRA1 at ER-mitochondria membrane contact sites.
Identification of novel PRA1 binding partners suggests a role for PRA1 within the early secretory pathway.
Title: Novel binding partners for Prenylated Rab Acceptor 1 identified by a split-ubiquitin yeast two-hybrid screen.
PRA1 plays a role in vesicular trafficking between the Golgi and cilia in differentiating and mature rod photoreceptors.
Title: A role for prenylated rab acceptor 1 in vertebrate photoreceptor development.
The study reports the identification of a Dexras1 interactor, prenylated Rab acceptor domain family member 1, which plays a novel role in adrenocorticotrophic hormone stimulated secretion.
Title: Prenylated Rab acceptor domain family member 1 is involved in stimulated ACTH secretion and inhibition.
A single C-terminal valine residue (Val185) is essential for the proper dimerization and ER export of prenylin.
Title: The C-terminus of prenylin is important in forming a dimer conformation necessary for endoplasmic-reticulum-to-Golgi transport.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables proline-rich region binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prenylated Rab acceptor protein 1

Names: GTP binding protein associated protein 1; PRA1 family protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.