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    Mki67 antigen identified by monoclonal antibody Ki 67 [ Mus musculus (house mouse) ]

    Gene ID: 17345, updated on 5-Nov-2024

    Summary

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    Official Symbol
    Mki67provided by MGI
    Official Full Name
    antigen identified by monoclonal antibody Ki 67provided by MGI
    Primary source
    MGI:MGI:106035
    See related
    Ensembl:ENSMUSG00000031004 AllianceGenome:MGI:106035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ki67; Ki-67; D630048A14Rik
    Summary
    Predicted to enable ATP binding activity and DNA binding activity. Involved in regulation of chromatin organization. Acts upstream of or within several processes, including cholangiocyte proliferation; hepatocyte proliferation; and stem cell proliferation. Located in chromosome; cytoplasm; and nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; colorectal cancer; endocrine gland cancer (multiple); graft-versus-host disease; and human immunodeficiency virus infectious disease. Orthologous to human MKI67 (marker of proliferation Ki-67). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E14 (RPKM 21.8), liver E14.5 (RPKM 14.9) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mki67 in Genome Data Viewer
    Location:
    7 F3; 7 81.32 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (135291513..135318286, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (135689784..135716450, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type E Neighboring gene microRNA 1962 Neighboring gene STARR-seq mESC enhancer starr_20364 Neighboring gene STARR-seq mESC enhancer starr_20365 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:142829243-142829444 Neighboring gene RIKEN cDNA 5830432E09 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:142844161-142844270 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:142849909-142850110 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:142860527-142860728 Neighboring gene STARR-positive B cell enhancer ABC_E1096 Neighboring gene STARR-positive B cell enhancer ABC_E1745 Neighboring gene STARR-positive B cell enhancer ABC_E8218 Neighboring gene predicted gene, 36431 Neighboring gene RIKEN cDNA 6330420H09 gene Neighboring gene predicted gene 45241

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression. Starborg M, et al. J Cell Sci, 1996 Jan. PMID 8834799
    2. A comparison of Ki-67 antigen presentation in acute generalized exanthematous pustulosis and pustular psoriasis. Chang SL, et al. Arch Dermatol Res, 2010 Sep. PMID 20336306
    3. Trophoblast glycogen cells differentiate early in the mouse ectoplacental cone: putative role during placentation. Tesser RB, et al. Histochem Cell Biol, 2010 Jul. PMID 20544215
    4. Towards a unified model of naive T cell dynamics across the lifespan. Rane S, et al. Elife, 2022 Jun 9. PMID 35678373, Free PMC Article
    5. Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement. Ding Z, et al. J Exp Med, 2024 Aug 5. PMID 38842525,

    See all (1000) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement.
      Title: Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement.
    2. Immunohistochemical expression of Ki-67 and Glypican-3 to distinguish aggressive from nonaggressive benign odontogenic tumors.
      Title: Immunohistochemical expression of Ki-67 and Glypican-3 to distinguish aggressive from nonaggressive benign odontogenic tumors.
    3. Expression of Ki67 as detected by MIB-1 and its association with histopathological high-risk factors among patients with retinoblastoma tumour: a cross-sectional study.
      Title: Expression of Ki67 as detected by MIB-1 and its association with histopathological high-risk factors among patients with retinoblastoma tumour: a cross-sectional study.
    4. Changes in Ki-67 in Residual Tumor and Outcome of Primary Inflammatory Breast Cancer Treated With Trimodality Therapy.
      Title: Changes in Ki-67 in Residual Tumor and Outcome of Primary Inflammatory Breast Cancer Treated With Trimodality Therapy.
    5. Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis.
      Title: Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis.
    6. Photobiomodulation invigorating collagen deposition, proliferating cell nuclear antigen and Ki67 expression during dermal wound repair in mice.
      Title: Photobiomodulation invigorating collagen deposition, proliferating cell nuclear antigen and Ki67 expression during dermal wound repair in mice.
    7. Deletion of NKX3.1 via CRISPR/Cas9 Induces Prostatic Intraepithelial Neoplasia in C57BL/6 Mice.
      Title: Deletion of NKX3.1 via CRISPR/Cas9 Induces Prostatic Intraepithelial Neoplasia in C57BL/6 Mice.
    8. Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis.
      Title: Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis.
    9. Somatostatin Analogs for Pancreatic Neuroendocrine Tumors: Any Benefit When Ki-67 Is >/=10%?
      Title: Somatostatin Analogs for Pancreatic Neuroendocrine Tumors: Any Benefit When Ki-67 Is ≥10%?
    10. S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3.
      Title: S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cholangiocyte proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hepatocyte proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proliferation marker protein Ki-67
    Names
    antigen KI-67 homolog
    antigen Ki67 homolog
    antigen identified by monoclonal antibody Ki-67 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081117.2 → NP_001074586.2  proliferation marker protein Ki-67

      Status: VALIDATED

      Source sequence(s)
      AC123047, AK052772, AK143677, BC053453
      Consensus CDS
      CCDS52421.1
      UniProtKB/Swiss-Prot
      E9PVX6, Q61769, Q7TSF6
      Related
      ENSMUSP00000033310.8, ENSMUST00000033310.9
      Conserved Domains (4) summary
      COG1716
      Location:11 → 92
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:7 → 101
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam08065
      Location:1109 → 1216
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:463 → 529
      PP1_bind; Protein phosphatase 1 binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      135291513..135318286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507413.5 → XP_006507476.1  proliferation marker protein Ki-67 isoform X2

      Conserved Domains (3) summary
      cd00060
      Location:7 → 101
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam08065
      Location:1854 → 1964
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:143 → 184
      PP1_bind; Protein phosphatase 1 binding

    2. XM_036152742.1 → XP_036008635.1  proliferation marker protein Ki-67 isoform X1

      Conserved Domains (2) summary
      pfam08065
      Location:2030 → 2140
      K167R; K167R (NUC007) repeat
      pfam15276
      Location:318 → 360
      PP1_bind; Protein phosphatase 1 binding
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9PVX6.1 GenPept UniProtKB/Swiss-Prot:E9PVX6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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