Ahsp alpha hemoglobin stabilizing protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ahspprovided by MGI
Official Full Name: alpha hemoglobin stabilizing proteinprovided by MGI
Primary source: MGI:MGI:2158492
See related: Ensembl:ENSMUSG00000121605 AllianceGenome:MGI:2158492
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EDRF; Eraf
Summary: Predicted to enable hemoglobin binding activity. Acts upstream of or within erythrocyte differentiation; protein folding; and protein stabilization. Located in cytoplasm. Is expressed in blood; cerebral cortex vascular element; embryo; and liver. Orthologous to human AHSP (alpha hemoglobin stabilizing protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 7 F3; 7

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (127902016..127902926)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000073.7 Chromosome 7 Reference GRCm39 C57BL/6J

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nrf2 expands the intracellular pool of the chaperone AHSP in a cellular model of beta-thalassemia.
Title: Nrf2 expands the intracellular pool of the chaperone AHSP in a cellular model of β-thalassemia.
eNOS reduced AHSP-bound alpha-globin approximately 6-fold faster than did the major erythrocyte hemoglobin reductases (cytochrome B5 reductase plus cytochrome B5). Our data support a model whereby redox-sensitive shuttling of EC alpha-globin between AHSP and eNOS regulates EC NO degradation and vascular tone.
Title: Endothelial cell α-globin and its molecular chaperone α-hemoglobin-stabilizing protein regulate arteriolar contractility.
role of alpha-hemoglobin stabilizing protein in hemoglobin assembly
Title: Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein.
Endogenous AHSP is not limiting for alpha-globin detoxification in beta-thalassemic mice.
Title: Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia.
The expression of AHSP in a subclone of murine erythroleukemia cells in relationship to prion protein on the cell surface is reported.
Title: Expression of alpha-hemoglobin stabilizing protein and cellular prion protein in a subclone of murine erythroleukemia cell line MEL.
AHSP also acts as a molecular chaperone to stabilize nascent alpha-globin for hemoglobin A assembly
Title: An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis.
activin A does not appear to affect the exocrine or endocrine components of the pancreas, but promotes differentiation of pancreatic tissue into intestine via a Shh-dependent mechanism
Title: Shh-dependent differentiation of intestinal tissue from embryonic pancreas by activin A.
developmental stage- and differentiation state-specific regulation of the nuclear transport of EKLF might be one of the steps necessary for the switch-on of the mammalian adult beta globin gene transcription
Title: Subcellular transport of EKLF and switch-on of murine adult beta maj globin gene transcription.
An abundant erythroid protein that stabilizes free alpha-haemoglobin.
Title: An abundant erythroid protein that stabilizes free alpha-haemoglobin.
These results support the hypothesis that EKLF acts as a transcription factor and a chromatin modulator for the AHSP and beta-globin genes and indicate that EKLF may play similar roles for other erythroid genes.
Title: Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hemoglobin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in erythrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein stabilization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: alpha-hemoglobin-stabilizing protein

Names: erythroid differentiation-related factor; erythroid-associated factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.