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    Rpain RPA interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 69723, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rpainprovided by MGI
    Official Full Name
    RPA interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1916973
    See related
    Ensembl:ENSMUSG00000018449 AllianceGenome:MGI:1916973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rip; 2400006N03Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within DNA metabolic process and response to UV. Predicted to be located in PML body; cytoplasm; and fibrillar center. Predicted to be active in nucleus. Is expressed in several structures, including cerebral cortex ventricular layer; egg cylinder; and oocyte. Orthologous to human RPAIN (RPA interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 17.5), testis adult (RPKM 16.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rpain in Genome Data Viewer
    Location:
    11 B4; 11 43.21 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70860403..70868759)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70970130..70977933)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene rabaptin, RAB GTPase binding effector protein 1 Neighboring gene ribosomal protein L23A, pseudogene 2 Neighboring gene predicted gene 12322 Neighboring gene nucleoporin 88 Neighboring gene STARR-seq mESC enhancer starr_29882 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70783671-70783780 Neighboring gene complement component 1, q subcomponent binding protein Neighboring gene DEAH-box helicase 33 Neighboring gene STARR-positive B cell enhancer ABC_E2359 Neighboring gene predicted gene, 22297 Neighboring gene STARR-positive B cell enhancer ABC_E256 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70833281-70833468 Neighboring gene Der1-like domain family, member 2 Neighboring gene MIS12 kinetochore complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Species-specific variation of RPA-interacting protein (RIP) splice isoforms. Kim K, et al. BMB Rep, 2009 Jan 31. PMID 19192389
    2. Sumoylation of the novel protein hRIP{beta} is involved in replication protein A deposition in PML nuclear bodies. Park J, et al. Mol Cell Biol, 2005 Sep. PMID 16135809, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The alternative splicing of RIPalpha in the Drosophila, Xenopus, and mouse system, was examined.
      Title: Species-specific variation of RPA-interacting protein (RIP) splice isoforms.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RPA-interacting protein
    Names
    RPA interacting protein delta 2
    RPA interacting protein epsilon

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252413.2 → NP_001239342.1  RPA-interacting protein isoform 3

      See identical proteins and their annotated locations for NP_001239342.1

      Status: VALIDATED

      Source sequence(s)
      AL596136, BC047996, BY576068, CB588111, DQ810269
      Consensus CDS
      CCDS56791.1
      UniProtKB/TrEMBL
      Q0PL81, Q0PL82
      Related
      ENSMUSP00000127315.2, ENSMUST00000167509.2
      Conserved Domains (3) summary
      pfam14766
      Location:8 → 46
      RPA_interact_N; Replication protein A interacting N-terminal
      pfam14767
      Location:59 → 123
      RPA_interact_M; Replication protein A interacting middle
      pfam14768
      Location:137 → 164
      RPA_interact_C; Replication protein A interacting C-terminal

    2. NM_001252414.2 → NP_001239343.1  RPA-interacting protein isoform 4

      See identical proteins and their annotated locations for NP_001239343.1

      Status: VALIDATED

      Source sequence(s)
      AL596136, BC047996, BY576068, CB588111, DQ810271
      Consensus CDS
      CCDS56792.1
      UniProtKB/TrEMBL
      Q0PL79, Q0PL80
      Related
      ENSMUSP00000128903.2, ENSMUST00000169965.8
      Conserved Domains (1) summary
      pfam14766
      Location:8 → 46
      RPA_interact_N; Replication protein A interacting N-terminal

    3. NM_001252415.2 → NP_001239344.1  RPA-interacting protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596136, BC047996, BY576068, CB588111, DQ810268
      Consensus CDS
      CCDS56790.1
      UniProtKB/TrEMBL
      J3QN46, Q0PL82
      Related
      ENSMUSP00000136592.2, ENSMUST00000178822.8
      Conserved Domains (3) summary
      pfam14766
      Location:8 → 46
      RPA_interact_N; Replication protein A interacting N-terminal
      pfam14767
      Location:59 → 123
      RPA_interact_M; Replication protein A interacting middle
      pfam14768
      Location:137 → 165
      RPA_interact_C; Replication protein A interacting C-terminal

    4. NM_027186.3 → NP_081462.1  RPA-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_081462.1

      Status: VALIDATED

      Source sequence(s)
      AK010289, AL596136, BC047996, BY576068, CB588111
      Consensus CDS
      CCDS24969.1
      UniProtKB/Swiss-Prot
      Q9CWY9
      UniProtKB/TrEMBL
      Q0PL83
      Related
      ENSMUSP00000018593.4, ENSMUST00000018593.10
      Conserved Domains (3) summary
      pfam14766
      Location:8 → 46
      RPA_interact_N; Replication protein A interacting N-terminal
      pfam14767
      Location:59 → 123
      RPA_interact_M; Replication protein A interacting middle
      pfam14768
      Location:137 → 217
      RPA_interact_C; Replication protein A interacting C-terminal

    RNA

    1. NR_156443.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL596136

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70860403..70868759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003949500.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWY9.1 GenPept UniProtKB/Swiss-Prot:Q9CWY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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