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    nedd4l.S NEDD4 like E3 ubiquitin protein ligase S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 399396, updated on 4-Nov-2024

    Summary

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    Official Symbol
    nedd4l.S
    Official Full Name
    NEDD4 like E3 ubiquitin protein ligase S homeolog
    Primary source
    Xenbase:XB-GENE-865849
    Locus tag
    XELAEV_18011058mg
    See related
    EnsemblRapid:ENSXLAG00005001699 AllianceGenome:Xenbase:XB-GENE-865849
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    nedd4; nedd4l; nedd4-2
    Summary
    Predicted to enable sodium channel inhibitor activity and ubiquitin protein ligase activity. Predicted to act upstream of or within several processes, including negative regulation of cation transmembrane transport; protein polyubiquitination; and regulation of dendrite morphogenesis. Predicted to be located in cytoplasm. Is expressed in mesoderm and musculoskeletal system. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human NEDD4L (NEDD4 like E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nedd4l.S in Genome Data Viewer
    Location:
    chromosome: 1S
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (189691751..189946983, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (169894163..170149458, complement)

    Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121399540 Neighboring gene MALT1 paracaspase S homeolog Neighboring gene alpha kinase 2 S homeolog Neighboring gene uncharacterized LOC108707325 Neighboring gene ATPase phospholipid transporting 8B1 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. E3 ligase Nedd4 promotes axon branching by downregulating PTEN. Drinjakovic J, et al. Neuron, 2010 Feb 11. PMID 20159448, Free PMC Article
    2. Molecular cloning of Nedd4 from Xenopus laevis. Rebhun JF, et al. DNA Seq, 1998. PMID 10524756
    3. NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling. Zhang Y, et al. Dev Biol, 2014 Aug 1. PMID 24833518
    4. Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases. Embark HM, et al. Kidney Int, 2004 Nov. PMID 15496163
    5. Participation of the ubiquitin-conjugating enzyme UBE2E3 in Nedd4-2-dependent regulation of the epithelial Na+ channel. Debonneville C, et al. Mol Cell Biol, 2004 Mar. PMID 14993279, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these findings suggest that regulation of Dvl protein levels by NEDD4L is essential for convergent extension during early Xenopus embryogenesis.
      Title: NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling.
    2. Results suggest a mechanism for epithelial Na+ channel regulation in which AMP-activated kinase promotes ENaC-Nedd4-2 interaction, inhibiting ENaC by increasing Nedd4-2-dependent ENaC retrieval from the plasma membrane.
      Title: AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2.
    3. results indicate that AMPK inhibits KCNQ1 activity by promoting Nedd4-2-dependent channel ubiquitination and retrieval from the plasma membrane.
      Title: AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells.
    4. This study suggested that Nedd4-regulated PTEN is a key regulator of terminal arborization in vivo.
      Title: E3 ligase Nedd4 promotes axon branching by downregulating PTEN.
    5. ENaC-beta regulation that occurs through IKKbeta-dependent Nedd4-2 phosphorylation at a recognized SGK1 and protein kinase A target site.
      Title: Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables sodium channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of sodium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NEDD4 like E3 ubiquitin protein ligase S homeolog
    Names
    neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase S homeolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001090789.1 → NP_001084258.1  NEDD4 like E3 ubiquitin protein ligase S homeolog

      See identical proteins and their annotated locations for NP_001084258.1

      Status: PROVISIONAL

      Source sequence(s)
      BC074133
      UniProtKB/TrEMBL
      O42573, Q6GMD5
      Related
      ENSXLAP00005005040.1, ENSXLAT00005005146.1
      Conserved Domains (4) summary
      cd04033
      Location:18 → 150
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:545 → 577
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:638 → 967
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:383 → 412
      WW; WW domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      189691751..189946983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018235316.2 → XP_018090805.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X17

      UniProtKB/TrEMBL
      A0A8J0TV22, O42573

    2. XM_018235308.2 → XP_018090797.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X16

      UniProtKB/TrEMBL
      A0A8J0TTB2, O42573

    3. XM_018235302.2 → XP_018090791.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X15

      UniProtKB/TrEMBL
      A0A8J0TLD4, O42573
      Related
      ENSXLAP00005005038.1, ENSXLAT00005005144.1

    4. XM_018235293.2 → XP_018090782.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X14

      UniProtKB/TrEMBL
      A0A8J0TW88, A0A974I2D9

    5. XM_018235324.2 → XP_018090813.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X20

      UniProtKB/TrEMBL
      A0A8J1LLQ4, A0A974I2D9
      Conserved Domains (4) summary
      smart00456
      Location:435 → 486
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:547 → 876
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:273 → 302
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain

    6. XM_041574475.1 → XP_041430409.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X13

      UniProtKB/TrEMBL
      A0A8J1LMM8
      Related
      ENSXLAP00005005031.1, ENSXLAT00005005137.1
      Conserved Domains (3) summary
      smart00456
      Location:480 → 510
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:776 → 1105
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cl14603
      Location:386 → 439
      C2; C2 domain

    7. XM_041574473.1 → XP_041430407.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X12

      UniProtKB/TrEMBL
      A0A8J1LLM2
      Conserved Domains (4) summary
      smart00456
      Location:672 → 723
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:784 → 1113
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:482 → 510
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cl14603
      Location:386 → 439
      C2; C2 domain

    8. XM_041574470.1 → XP_041430404.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X11

      UniProtKB/TrEMBL
      A0A8J1LMM4
      Related
      ENSXLAP00005005030.1, ENSXLAT00005005136.1
      Conserved Domains (4) summary
      smart00456
      Location:730 → 781
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:842 → 1171
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:681 → 711
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cl14603
      Location:386 → 439
      C2; C2 domain

    9. XM_018235284.2 → XP_018090773.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X10

      UniProtKB/TrEMBL
      A0A8J0TLC1

    10. XM_018235220.2 → XP_018090709.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X2

      UniProtKB/TrEMBL
      A0A8J0TTQ9

    11. XM_018235267.2 → XP_018090756.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X8

      UniProtKB/TrEMBL
      A0A8J0TTU4
      Related
      ENSXLAP00005005029.1, ENSXLAT00005005135.1

    12. XM_018235230.2 → XP_018090719.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X3

      UniProtKB/TrEMBL
      A0A8J0TTR7
      Related
      ENSXLAP00005005026.1, ENSXLAT00005005132.1

    13. XM_018235247.2 → XP_018090736.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X6

      UniProtKB/TrEMBL
      A0A8J0TL89

    14. XM_018235210.2 → XP_018090699.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A8J0TW19

    15. XM_041574449.1 → XP_041430383.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X5

      UniProtKB/TrEMBL
      A0A8J1LLD7
      Conserved Domains (4) summary
      smart00456
      Location:679 → 709
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:934 → 1263
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:482 → 510
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cl14603
      Location:386 → 439
      C2; C2 domain

    16. XM_018235275.2 → XP_018090764.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X9

      UniProtKB/TrEMBL
      A0A8J0TW75

    17. XM_018235257.2 → XP_018090746.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X7

      UniProtKB/TrEMBL
      A0A8J0TL98

    18. XM_018235239.2 → XP_018090728.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X4

      UniProtKB/TrEMBL
      A0A8J0TW45
      Related
      ENSXLAP00005005028.1, ENSXLAT00005005134.1

    19. XM_041574503.1 → XP_041430437.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X19

      UniProtKB/TrEMBL
      A0A8J1LLP9, A0A974I2D9
      Conserved Domains (4) summary
      smart00456
      Location:299 → 329
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:574 → 903
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:413 → 443
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cl14603
      Location:6 → 59
      C2; C2 domain

    20. XM_041574498.1 → XP_041430432.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X18

      UniProtKB/TrEMBL
      A0A8J1LLP5, A0A974I2D9
      Related
      ENSXLAP00005005025.1, ENSXLAT00005005131.1
      Conserved Domains (4) summary
      smart00456
      Location:316 → 346
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:591 → 920
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00201
      Location:430 → 460
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cl14603
      Location:23 → 76
      C2; C2 domain

    21. XM_041574508.1 → XP_041430442.1  NEDD4 like E3 ubiquitin protein ligase S homeolog isoform X20

      UniProtKB/TrEMBL
      A0A8J1LLQ4, A0A974I2D9
      Conserved Domains (4) summary
      smart00456
      Location:435 → 486
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:547 → 876
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00397
      Location:273 → 302
      WW; WW domain
      cl14603
      Location:1 → 32
      C2; C2 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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