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    fscn1.L fascin actin-bundling protein 1 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 397934, updated on 18-Sep-2024

    Summary

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    Official Symbol
    fscn1.L
    Official Full Name
    fascin actin-bundling protein 1 L homeolog
    Primary source
    Xenbase:XB-GENE-488983
    Locus tag
    XELAEV_18045057mg
    See related
    EnsemblRapid:ENSXLAG00005025200
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    fscn; fscn1
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    Genomic context

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    See fscn1.L in Genome Data Viewer
    Location:
    chromosome: 9_10L
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (95365233..95389901)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (84786345..84811104)

    Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene trinucleotide repeat-containing gene 18 protein Neighboring gene F-box and leucine-rich repeat protein 18 L homeolog Neighboring gene ring finger protein 216 L homeolog Neighboring gene SMAD specific E3 ubiquitin protein ligase 1 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A vertebrate homolog of the actin-bundling protein fascin. Holthuis JC, et al. Biochim Biophys Acta, 1994 Sep 13. PMID 8086462
    2. Protein interactomes of protein phosphatase 2A B55 regulatory subunits reveal B55-mediated regulation of replication protein A under replication stress. Wang F, et al. Sci Rep, 2018 Feb 8. PMID 29422626, Free PMC Article
    3. Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nishiyama A, et al. Nat Commun, 2020 Mar 6. PMID 32144273, Free PMC Article
    4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within establishment or maintenance of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell projection membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in filopodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microvillus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fascin
    Names
    fascin homolog 1, actin-bundling protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001088112.1 → NP_001081581.1  fascin

      See identical proteins and their annotated locations for NP_001081581.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097600
      UniProtKB/Swiss-Prot
      Q91837
      UniProtKB/TrEMBL
      A0A974H4B7, Q4QR37
      Related
      ENSXLAP00005074883.1, ENSXLAT00005076463.1
      Conserved Domains (2) summary
      cd00257
      Location:5 → 126
      Fascin; Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an ...
      pfam06268
      Location:260 → 369
      Fascin; Fascin domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      95365233..95389901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91837.1 GenPept UniProtKB/Swiss-Prot:Q91837

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.