dhrs3.L dehydrogenase/reductase (SDR family) member 3 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: dhrs3.L
Official Full Name: dehydrogenase/reductase (SDR family) member 3 L homeolog
Primary source: Xenbase:XB-GENE-955331
Locus tag: XELAEV_18035730mg
See related: EnsemblRapid:ENSXLAG00005016394
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: dhrs3
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Genomic context

Location:: chromosome: 7L

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7L	NC_054383.1 (99627471..99645567)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	7L	NC_030736.1 (89783076..89801527)

Chromosome 7L - NC_054383.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

dhrs3 participates in atRA metabolism by reducing atRAL levels and is required for proper anteroposterior axis formation, neuroectoderm patterning, and somitogenesis.
Title: Dhrs3 protein attenuates retinoic acid signaling and is required for early embryonic patterning.
Data show that dhrs3 was activated at the onset of gastrulation, and remained highly expressed at later stages of embryonic development.
Title: Developmental expression of Xenopus short-chain dehydrogenase/reductase 3.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of retinoic acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of retinoic acid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinoid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in lipid droplet	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dehydrogenase/reductase (SDR family) member 3 L homeolog

Names: dehydrogenase/reductase 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001092373.1 → NP_001085842.1 dehydrogenase/reductase (SDR family) member 3 L homeolog precursor

See identical proteins and their annotated locations for NP_001085842.1

Status: PROVISIONAL

Source sequence(s)

BC073416

UniProtKB/TrEMBL

A0A974CGU3, B9VVF7, Q6GNT6

Related

ENSXLAP00005048264.1, ENSXLAT00005049379.1

Conserved Domains (2) summary

cd05339
Location:53 → 281

17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

PRK09072
Location:35 → 288

PRK09072; short chain dehydrogenase; Provisional