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    ppara.S peroxisome proliferator activated receptor alpha S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 398843, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ppara.S
    Official Full Name
    peroxisome proliferator activated receptor alpha S homeolog
    Primary source
    Xenbase:XB-GENE-17339020
    Locus tag
    XELAEV_18019740mg
    See related
    EnsemblRapid:ENSXLAG00005000228
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    nr1c1; ppara; xppara; PPARalpha; xPPARalpha
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    Genomic context

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    See ppara.S in Genome Data Viewer
    Location:
    chromosome: 3S
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (1708406..1725456, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3S NC_030729.1 (1706878..1723655, complement)

    Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene tubulin tyrosine ligase like 1 S homeolog Neighboring gene uncharacterized LOC121402085 Neighboring gene malonyl-CoA-acyl carrier protein transacylase S homeolog Neighboring gene uncharacterized LOC121402086 Neighboring gene uncharacterized LOC121402087

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Xenopus peroxisome proliferator activated receptors: genomic organization, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids. Krey G, et al. J Steroid Biochem Mol Biol, 1993 Dec. PMID 8274443
    2. Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Dreyer C, et al. Cell, 1992 Mar 6. PMID 1312391
    3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC68537

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cholesterol storage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peroxisome proliferator-activated receptor alpha
    Names
    PPAR-alpha
    nuclear receptor subfamily 1 group C member 1
    xPPAR alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089813.1 → NP_001083282.1  peroxisome proliferator-activated receptor alpha

      See identical proteins and their annotated locations for NP_001083282.1

      Status: PROVISIONAL

      Source sequence(s)
      BC060004
      UniProtKB/Swiss-Prot
      P37232
      UniProtKB/TrEMBL
      Q6PAY0
      Conserved Domains (2) summary
      cd06932
      Location:208 → 473
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:108 → 191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      1708406..1725456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041587556.1 → XP_041443490.1  peroxisome proliferator-activated receptor alpha isoform X3

      UniProtKB/TrEMBL
      A0A8J1MR19
      Conserved Domains (2) summary
      cd06932
      Location:108 → 373
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cl02596
      Location:76 → 91
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    2. XM_041587555.1 → XP_041443489.1  peroxisome proliferator-activated receptor alpha isoform X2

      UniProtKB/TrEMBL
      A0A8J1MNX3
      Conserved Domains (2) summary
      cd06932
      Location:132 → 397
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cl02596
      Location:55 → 115
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    3. XM_041587552.1 → XP_041443486.1  peroxisome proliferator-activated receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      P37232
      UniProtKB/TrEMBL
      A0A974D847, Q6AXA9
      Conserved Domains (2) summary
      cd06932
      Location:208 → 473
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:108 → 191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

    4. XM_041587553.1 → XP_041443487.1  peroxisome proliferator-activated receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      P37232
      UniProtKB/TrEMBL
      A0A974D847, Q6AXA9
      Conserved Domains (2) summary
      cd06932
      Location:208 → 473
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:108 → 191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

    5. XM_041587554.1 → XP_041443488.1  peroxisome proliferator-activated receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      P37232
      UniProtKB/TrEMBL
      A0A974D847, Q6AXA9
      Conserved Domains (2) summary
      cd06932
      Location:208 → 473
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:108 → 191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

    6. XM_041587551.1 → XP_041443485.1  peroxisome proliferator-activated receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      P37232
      UniProtKB/TrEMBL
      A0A974D847, Q6AXA9
      Related
      ENSXLAP00005000573.1, ENSXLAT00005000600.1
      Conserved Domains (2) summary
      cd06932
      Location:208 → 473
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:108 → 191
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37232.1 GenPept UniProtKB/Swiss-Prot:P37232

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