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    hnrnpk.S heterogeneous nuclear ribonucleoprotein K S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 380255, updated on 17-Aug-2024

    Summary

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    Official Symbol
    hnrnpk.S
    Official Full Name
    heterogeneous nuclear ribonucleoprotein K S homeolog
    Primary source
    Xenbase:XB-GENE-6253918
    Locus tag
    XELAEV_18010151mg
    See related
    EnsemblRapid:ENSXLAG00005012078
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    hnrpk; hnrnpk
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    Genomic context

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    See hnrnpk.S in Genome Data Viewer
    Location:
    chromosome: 1S
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (124082986..124094218, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (109325400..109336993, complement)

    Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene ubiquilin 1 S homeolog Neighboring gene FERM domain containing 3 S homeolog Neighboring gene recQ-mediated genome instability protein 1-like Neighboring gene solute carrier family 28 member 3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel role for the nuclear localization signal in regulating hnRNP K protein stability in vivo. Hutchins EJ, et al. Biochem Biophys Res Commun, 2016 Sep 16. PMID 27501755
    2. Phosphorylation of heterogeneous nuclear ribonucleoprotein K at an extracellular signal-regulated kinase phosphorylation site promotes neurofilament-medium protein expression and axon outgrowth in Xenopus. Hutchins EJ, et al. Neurosci Lett, 2015 Oct 21. PMID 26409787
    3. Heterogeneous nuclear ribonucleoprotein K, an RNA-binding protein, is required for optic axon regeneration in Xenopus laevis. Liu Y, et al. J Neurosci, 2012 Mar 7. PMID 22399778, Free PMC Article
    4. A crucial role for hnRNP K in axon development in Xenopus laevis. Liu Y, et al. Development, 2008 Sep. PMID 18725517
    5. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel role for the nuclear localization signal in regulating hnRNP K protein stability in vivo has been described.
      Title: A novel role for the nuclear localization signal in regulating hnRNP K protein stability in vivo.
    2. a previously unidentified function of phosphorylation at this phylogenetically conserved site and implicates hnRNPK as an intracellular molecular target of ERK-mediated signaling in axon outgrowth.
      Title: Phosphorylation of heterogeneous nuclear ribonucleoprotein K at an extracellular signal-regulated kinase phosphorylation site promotes neurofilament-medium protein expression and axon outgrowth in Xenopus.
    3. hnRNP K is essential for successful optic axon regeneration via a novel post-transcriptional regulatory pathway.
      Title: Heterogeneous nuclear ribonucleoprotein K, an RNA-binding protein, is required for optic axon regeneration in Xenopus laevis.
    4. A crucial role is reported for hnrpk in axon development in Xenoops laevis.
      Title: A crucial role for hnRNP K in axon development in Xenopus laevis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC53459

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein K S homeolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001087094.1 → NP_001080563.1  heterogeneous nuclear ribonucleoprotein K S homeolog

      See identical proteins and their annotated locations for NP_001080563.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044711
      UniProtKB/TrEMBL
      A0A974I191, Q7ZXK8, Q9PSI1
      Related
      ENSXLAP00005035377.1, ENSXLAT00005036270.1
      Conserved Domains (3) summary
      cd00105
      Location:322 → 385
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:119 → 183
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam08067
      Location:6 → 40
      ROKNT; ROKNT (NUC014) domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      124082986..124094218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018233808.2 → XP_018089297.1  heterogeneous nuclear ribonucleoprotein K S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A974I191, Q7ZXK8, Q9PSI1

    2. XM_018233813.2 → XP_018089302.1  heterogeneous nuclear ribonucleoprotein K S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A974I191, Q7ZXK8, Q9PSI1

    3. XM_018233820.2 → XP_018089309.1  heterogeneous nuclear ribonucleoprotein K S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A974I191, Q7ZXK8, Q9PSI1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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