txnrd3.L thioredoxin reductase 3 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: txnrd3.L
Official Full Name: thioredoxin reductase 3 L homeolog
Primary source: Xenbase:XB-GENE-973843
Locus tag: XELAEV_18023974mg
See related: EnsemblRapid:ENSXLAG00005025208
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: txnrd3
Summary: The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals and some vertebrates. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes the third TrxR, which unlike the other two isozymes, contains an additional N-terminal glutaredoxin (Grx) domain, and shows highest expression in testis. The Grx domain allows this isozyme to participate in both Trx and glutathione systems. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. A homeolog of this gene is found on chromosome 4S. [provided by RefSeq, Jul 2017]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4L

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (133121598..133152242, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (127874871..127905263, complement)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables glutathione-disulfide reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables thioredoxin-disulfide reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell redox homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glutathione metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thioredoxin reductase 3 L homeolog

NP_001087660.2

EC 1.8.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001094191.3 → NP_001087660.2 thioredoxin reductase 3 L homeolog

Status: REVIEWED

Source sequence(s)

BC081053, BJ068183, BJ637734, BQ733110, DC097890, DR721822, EB476942

UniProtKB/TrEMBL

A0A8J0PYE6, A0A974HPT5, Q66J56

Related

ENSXLAP00005075194.1, ENSXLAT00005076774.1

Conserved Domains (2) summary

cd03419
Location:21 → 102

GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

TIGR01438
Location:110 → 598

TGR; thioredoxin and glutathione reductase selenoprotein

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

133121598..133152242 complement

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GenBank, FASTA, Sequence Viewer (Graphics)