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    STK26 serine/threonine kinase 26 [ Homo sapiens (human) ]

    Gene ID: 51765, updated on 3-Nov-2024

    Summary

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    Official Symbol
    STK26provided by HGNC
    Official Full Name
    serine/threonine kinase 26provided by HGNC
    Primary source
    HGNC:HGNC:18174
    See related
    Ensembl:ENSG00000134602 MIM:300547; AllianceGenome:HGNC:18174
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MASK; MST4
    Summary
    The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in endometrium (RPKM 22.0), bone marrow (RPKM 21.7) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    Xq26.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (132023302..132075943)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (130347539..130400176)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (131157330..131209971)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene firre intergenic repeating RNA element Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:130937096-130937596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:130937597-130938097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29965 Neighboring gene Sharpr-MPRA regulatory region 13107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29967 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:130960090-130960590 Neighboring gene PNKD pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:131057048-131058247 Neighboring gene RNA, 5S ribosomal pseudogene 514 Neighboring gene Sharpr-MPRA regulatory region 3545 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:131156878-131157424 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:131157425-131157972 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21004 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:131253207-131254142 Neighboring gene FERM domain containing 7 Neighboring gene AGK pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mst4, a novel cardiac STRIPAK complex-associated kinase, regulates cardiomyocyte growth and survival and is upregulated in human cardiomyopathy.
      Title: Mst4, a novel cardiac STRIPAK complex-associated kinase, regulates cardiomyocyte growth and survival and is upregulated in human cardiomyopathy.
    2. MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages.
      Title: MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages.
    3. STE20-type kinases MST3 and MST4 promote the progression of hepatocellular carcinoma: Evidence from human cell culture and expression profiling of liver biopsies.
      Title: STE20-type kinases MST3 and MST4 promote the progression of hepatocellular carcinoma: Evidence from human cell culture and expression profiling of liver biopsies.
    4. The mammalian Sterile 20-like kinase 4 (MST4) signaling in tumor progression: Implications for therapy.
      Title: The mammalian Sterile 20-like kinase 4 (MST4) signaling in tumor progression: Implications for therapy.
    5. MST4: A Potential Oncogene and Therapeutic Target in Breast Cancer.
      Title: MST4: A Potential Oncogene and Therapeutic Target in Breast Cancer.
    6. An MST4-pbeta-Catenin(Thr40) Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis.
      Title: An MST4-pβ-Catenin(Thr40) Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis.
    7. A network-based variable selection approach for identification of modules and biomarker genes associated with end-stage kidney disease.
      Title: A network-based variable selection approach for identification of modules and biomarker genes associated with end-stage kidney disease.
    8. Tripartite motif containing 59 (TRIM59) promotes esophageal cancer progression via promoting MST4 expression and ERK pathway.
      Title: Tripartite motif containing 59 (TRIM59) promotes esophageal cancer progression via promoting MST4 expression and ERK pathway.
    9. MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway.
      Title: MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway.
    10. Downregulation of MST4 Underlies a Novel Inhibitory Role of MicroRNA Let-7a in the Progression of Retinoblastoma.
      Title: Downregulation of MST4 Underlies a Novel Inhibitory Role of MicroRNA Let-7a in the Progression of Retinoblastoma.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microvillus assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi-associated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 26
    Names
    Mst3 and SOK1-related kinase
    STE20-like kinase 4
    STE20-like kinase MST4
    mammalian Ste20-like protein kinase 4
    mammalian sterile 20-like 4
    serine/threonine protein kinase 26
    serine/threonine protein kinase MST4
    serine/threonine-protein kinase MASK
    NP_001035917.1
    NP_001035918.1
    NP_057626.2
    XP_047298111.1
    XP_047298112.1
    XP_054183158.1
    XP_054183159.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029562.1 RefSeqGene

      Range
      5086..57727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042452.2 → NP_001035917.1  serine/threonine-protein kinase 26 isoform 3

      See identical proteins and their annotated locations for NP_001035917.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3) is shorter compared to isoform 1, and lacks kinase activity.
      Source sequence(s)
      AF344883, AL109749, BC070056
      Consensus CDS
      CCDS43995.1
      UniProtKB/TrEMBL
      Q499L9
      Related
      ENSP00000419702.1, ENST00000496850.1
      Conserved Domains (1) summary
      cl21453
      Location:19 → 233
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001042453.2 → NP_001035918.1  serine/threonine-protein kinase 26 isoform 2

      See identical proteins and their annotated locations for NP_001035918.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AK075107, BC070056, DA760264
      Consensus CDS
      CCDS48168.1
      UniProtKB/TrEMBL
      Q9NWX4
      Related
      ENSP00000377868.2, ENST00000394335.6
      Conserved Domains (1) summary
      cl21453
      Location:15 → 218
      PKc_like; Protein Kinases, catalytic domain

    3. NM_016542.4 → NP_057626.2  serine/threonine-protein kinase 26 isoform 1

      See identical proteins and their annotated locations for NP_057626.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF231012, BC070056, DA760264
      Consensus CDS
      CCDS14631.1
      UniProtKB/Swiss-Prot
      B2RAU2, Q3ZB77, Q8NC04, Q9BXC3, Q9BXC4, Q9P289
      UniProtKB/TrEMBL
      Q499L9
      Related
      ENSP00000377867.2, ENST00000394334.7
      Conserved Domains (1) summary
      cd06640
      Location:19 → 295
      STKc_MST4; Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      132023302..132075943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442155.1 → XP_047298111.1  serine/threonine-protein kinase 26 isoform X1

    2. XM_047442156.1 → XP_047298112.1  serine/threonine-protein kinase 26 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      130347539..130400176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327183.1 → XP_054183158.1  serine/threonine-protein kinase 26 isoform X1

    2. XM_054327184.1 → XP_054183159.1  serine/threonine-protein kinase 26 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P289.2 GenPept UniProtKB/Swiss-Prot:Q9P289

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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