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    Tpd52l2 tumor protein D52-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 66314, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tpd52l2provided by MGI
    Official Full Name
    tumor protein D52-like 2provided by MGI
    Primary source
    MGI:MGI:1913564
    See related
    Ensembl:ENSMUSG00000000827 AllianceGenome:MGI:1913564
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D54; 2810411G23Rik
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Orthologous to human TPD52L2 (TPD52 like 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 19.2), bladder adult (RPKM 18.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tpd52l2 in Genome Data Viewer
    Location:
    2 H4; 2 103.63 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181138951..181160103)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181497142..181517962)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 46 Neighboring gene predicted gene, 22708 Neighboring gene STARR-positive B cell enhancer mm9_chr2:181218272-181218572 Neighboring gene STARR-seq mESC enhancer starr_06754 Neighboring gene STARR-positive B cell enhancer ABC_E274 Neighboring gene abhydrolase domain containing 16B Neighboring gene predicted gene, 25184 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 Neighboring gene STARR-positive B cell enhancer ABC_E3426 Neighboring gene uridine-cytidine kinase 1-like 1 Neighboring gene uridine-cytidine kinase 1-like 1, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Adissu HA, et al. Dis Model Mech, 2014 May. PMID 24652767, Free PMC Article
    2. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. McLelland GL, et al. Elife, 2018 Apr 20. PMID 29676259, Free PMC Article
    3. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
    4. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683
    5. Proteomic and yeast 2-hybrid screens to identify PTEN binding partners. Tibarewal P, et al. Adv Biol Regul, 2024 Jan. PMID 37839992

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tumor protein D54

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291197.2 → NP_001278126.1  tumor protein D54 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AL929094
      UniProtKB/TrEMBL
      Q9CZ22
      Conserved Domains (1) summary
      pfam04201
      Location:55 → 212
      TPD52; Tumour protein D52 family

    2. NM_001291200.2 → NP_001278129.1  tumor protein D54 isoform c

      See identical proteins and their annotated locations for NP_001278129.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
      Source sequence(s)
      AL929094
      Consensus CDS
      CCDS71219.1
      UniProtKB/TrEMBL
      Q3TAI4, Q9CZ22
      Related
      ENSMUSP00000000844.9, ENSMUST00000000844.15
      Conserved Domains (1) summary
      pfam04201
      Location:55 → 197
      TPD52; Tumour protein D52 family

    3. NM_001291201.2 → NP_001278130.1  tumor protein D54 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
      Source sequence(s)
      AL929094
      UniProtKB/TrEMBL
      Q3TUJ9, Q8BKP1
      Conserved Domains (1) summary
      pfam04201
      Location:55 → 163
      TPD52; tumor protein D52 family

    4. NM_001291202.2 → NP_001278131.1  tumor protein D54 isoform e

      See identical proteins and their annotated locations for NP_001278131.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (e) that is shorter than isoform a.
      Source sequence(s)
      AL929094
      Consensus CDS
      CCDS71220.1
      UniProtKB/TrEMBL
      Q8BKP1, Q9CZ22
      Related
      ENSMUSP00000068888.3, ENSMUST00000069712.9
      Conserved Domains (1) summary
      pfam04201
      Location:55 → 191
      TPD52; Tumour protein D52 family

    5. NM_001291203.2 → NP_001278132.1  tumor protein D54 isoform f

      See identical proteins and their annotated locations for NP_001278132.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon in both the central and 3' coding regions, compared to variant 1, resulting in an isoform (f) that is shorter than isoform a.
      Source sequence(s)
      AL929094
      Consensus CDS
      CCDS71221.1
      UniProtKB/TrEMBL
      Q3TUJ9, Q9CZ22
      Related
      ENSMUSP00000104428.2, ENSMUST00000108800.8
      Conserved Domains (1) summary
      pfam04201
      Location:55 → 177
      TPD52; Tumour protein D52 family

    6. NM_001291204.2 → NP_001278133.1  tumor protein D54 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks three alternate exons that result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (g) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AL929094
      UniProtKB/TrEMBL
      Q3TAI4, Q3TUJ9

    7. NM_001373959.2 → NP_001360888.1  tumor protein D54 isoform h

      Status: VALIDATED

      Source sequence(s)
      AL929094
      Consensus CDS
      CCDS89610.1
      UniProtKB/TrEMBL
      A2AUD5, Q9CZ22
      Related
      ENSMUSP00000104427.4, ENSMUST00000108799.10
      Conserved Domains (1) summary
      pfam04201
      Location:55 → 220
      TPD52; tumor protein D52 family

    8. NM_001373960.2 → NP_001360889.1  tumor protein D54 isoform i

      Status: VALIDATED

      Source sequence(s)
      AL929094
      UniProtKB/TrEMBL
      Q9CZ22
      Conserved Domains (1) summary
      pfam04201
      Location:55 → 201
      TPD52; tumor protein D52 family

    9. NM_001373961.2 → NP_001360890.1  tumor protein D54 isoform j

      Status: VALIDATED

      Source sequence(s)
      AL929094
      UniProtKB/TrEMBL
      Q9CZ22
      Conserved Domains (1) summary
      pfam04201
      Location:55 → 200
      TPD52; tumor protein D52 family

    10. NM_001406353.1 → NP_001393282.1  tumor protein D54 isoform k

      Status: VALIDATED

      Source sequence(s)
      AL929094

    11. NM_001406354.1 → NP_001393283.1  tumor protein D54 isoform l

      Status: VALIDATED

      Source sequence(s)
      AL929094

    12. NM_001406355.1 → NP_001393284.1  tumor protein D54 isoform m

      Status: VALIDATED

      Source sequence(s)
      AL929094

    13. NM_001406356.1 → NP_001393285.1  tumor protein D54 isoform n

      Status: VALIDATED

      Source sequence(s)
      AL929094
      Related
      ENSMUSP00000138837.2, ENSMUST00000184849.8

    14. NM_001406357.1 → NP_001393286.1  tumor protein D54 isoform o

      Status: VALIDATED

      Source sequence(s)
      AL929094

    15. NM_001406358.1 → NP_001393287.1  tumor protein D54 isoform p

      Status: VALIDATED

      Source sequence(s)
      AL929094

    16. NM_001406359.1 → NP_001393288.1  tumor protein D54 isoform q

      Status: VALIDATED

      Source sequence(s)
      AL929094

    17. NM_001406360.1 → NP_001393289.1  tumor protein D54 isoform r

      Status: VALIDATED

      Source sequence(s)
      AL929094

    18. NM_001406361.1 → NP_001393290.1  tumor protein D54 isoform s

      Status: VALIDATED

      Source sequence(s)
      AL929094

    19. NM_001406362.1 → NP_001393291.1  tumor protein D54 isoform t

      Status: VALIDATED

      Source sequence(s)
      AL929094

    20. NM_001406363.1 → NP_001393292.1  tumor protein D54 isoform u

      Status: VALIDATED

      Source sequence(s)
      AL929094

    21. NM_025482.4 → NP_079758.2  tumor protein D54 isoform b

      See identical proteins and their annotated locations for NP_079758.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AL929094
      Consensus CDS
      CCDS17214.1
      UniProtKB/Swiss-Prot
      Q3TVY1, Q9CYZ2
      UniProtKB/TrEMBL
      Q9CZ22
      Related
      ENSMUSP00000117690.2, ENSMUST00000149163.8
      Conserved Domains (1) summary
      pfam04201
      Location:55 → 211
      TPD52; Tumour protein D52 family

    RNA

    1. NR_111899.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks an alternate exon in both the 5' and 3' regions, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL929094

    2. NR_176048.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL929094

    3. NR_176049.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL929094

    4. NR_176050.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL929094

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      181138951..181160103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500701.2 → XP_006500764.1  tumor protein D54 isoform X4

      UniProtKB/TrEMBL
      F6VQ81
      Related
      ENSMUST00000183956.8
      Conserved Domains (1) summary
      pfam04201
      Location:55 → 139
      TPD52; tumor protein D52 family

    2. XM_036162449.1 → XP_036018342.1  tumor protein D54 isoform X3

      Conserved Domains (1) summary
      pfam04201
      Location:55 → 138
      TPD52; tumor protein D52 family

    3. XM_036162448.1 → XP_036018341.1  tumor protein D54 isoform X2

      Conserved Domains (1) summary
      pfam04201
      Location:55 → 158
      TPD52; tumor protein D52 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CYZ2.1 GenPept UniProtKB/Swiss-Prot:Q9CYZ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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