Wdfy2 WD repeat and FYVE domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdfy2provided by MGI
Official Full Name: WD repeat and FYVE domain containing 2provided by MGI
Primary source: MGI:MGI:2442811
See related: Ensembl:ENSMUSG00000014547 AllianceGenome:MGI:2442811
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ProF; ZFYVE22; 5830485M08; B130024L21Rik
Summary: Predicted to enable metal ion binding activity. Involved in positive regulation of fat cell differentiation. Located in cytoplasm. Is expressed in central nervous system; male reproductive system; and urinary system. Orthologous to human WDFY2 (WD repeat and FYVE domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 5.1), adrenal adult (RPKM 5.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 33.23 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (63075110..63198958)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (62837661..62961509)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls Endosomal Localization of the Insulin Receptor and IRS1/2.
Title: WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls Endosomal Localization of the Insulin Receptor and IRS1/2.
Data show that ProF binds to Foxo1, a negative regulator of insulin action and adipogenesis, and facilitates the phosphorylation and thus inactivation of Foxo1 by Akt.
Title: Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis.
The ProF protein partially co-localizes with EEA1 on vesicular structures and binds to the protein kinases Akt and PKCzeta/lambda (protein kinase Czeta/lambda) via its WD-repeat propeller.
Title: A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487771

NoName (e-PCR)
- UniSTS:237204

NoName (e-PCR)
- UniSTS:237209

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: WD repeat and FYVE domain-containing protein 2

Names: WD40- and FYVE domain-containing protein 2; propeller-FYVE protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175546.4 → NP_780755.2 WD repeat and FYVE domain-containing protein 2

See identical proteins and their annotated locations for NP_780755.2

Status: VALIDATED

Source sequence(s)

AK086275, AK151817, CB520148

Consensus CDS

CCDS27192.1

UniProtKB/Swiss-Prot

Q3U9F3, Q8BUB4

Related

ENSMUSP00000014691.9, ENSMUST00000014691.10

Conserved Domains (3) summary

cd15718
Location:279 → 348

FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins

sd00039
Location:159 → 197

7WD40; WD40 repeat [structural motif]

cl29593
Location:16 → 272

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

63075110..63198958

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519064.2 → XP_006519127.1 WD repeat and FYVE domain-containing protein 2 isoform X2

Conserved Domains (3) summary

cd15718
Location:190 → 259

FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins

sd00039
Location:70 → 108

7WD40; WD40 repeat [structural motif]

cl29593
Location:11 → 183

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036158611.1 → XP_036014504.1 WD repeat and FYVE domain-containing protein 2 isoform X1

Conserved Domains (3) summary

cd15718
Location:213 → 282

FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins

sd00039
Location:93 → 131

7WD40; WD40 repeat [structural motif]

cl29593
Location:2 → 210

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036158612.1 → XP_036014505.1 WD repeat and FYVE domain-containing protein 2 isoform X2

Conserved Domains (3) summary

cd15718
Location:190 → 259

FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins

sd00039
Location:70 → 108

7WD40; WD40 repeat [structural motif]

cl29593
Location:11 → 183

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...