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    Phkg2 phosphorylase kinase, gamma 2 (testis) [ Mus musculus (house mouse) ]

    Gene ID: 68961, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Phkg2provided by MGI
    Official Full Name
    phosphorylase kinase, gamma 2 (testis)provided by MGI
    Primary source
    MGI:MGI:1916211
    See related
    Ensembl:ENSMUSG00000030815 AllianceGenome:MGI:1916211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500017I02Rik
    Summary
    Enables phosphorylase kinase activity. Involved in glycogen catabolic process and positive regulation of glycogen catabolic process. Predicted to be located in cytosol. Predicted to be part of phosphorylase kinase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease IXc; and liver cirrhosis. Orthologous to human PHKG2 (phosphorylase kinase catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 599.3) and thymus adult (RPKM 26.5) See more
    Orthologs
    human all
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    Genomic context

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    See Phkg2 in Genome Data Viewer
    Location:
    7 F3; 7 69.6 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127169252..127182479)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127573345..127583307)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Snf2-related CREBBP activator protein Neighboring gene small nucleolar RNA, H/ACA box 30 Neighboring gene transmembrane protein 265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134716729-134716937 Neighboring gene STARR-positive B cell enhancer ABC_E6607 Neighboring gene cilia and flagella associated protein 119 Neighboring gene ring finger protein 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of liver GSD IX γ2 pathophysiology in a novel Phkg2(-/-) mouse model. Gibson RA, et al. Mol Genet Metab, 2021 Jul. PMID 34083142, Free PMC Article
    2. Elucidation of the molecular mechanisms underlying adverse reactions associated with a kinase inhibitor using systems toxicology. Amemiya T, et al. NPJ Syst Biol Appl, 2015. PMID 28725458, Free PMC Article
    3. Circular RNA profile in liver tissue of EpCAM knockout mice. Yang Y, et al. Int J Mol Med, 2019 Sep. PMID 31524221, Free PMC Article
    4. Analysis of a lung defect in autophagy-deficient mouse strains. Cheong H, et al. Autophagy, 2014 Jan. PMID 24275123, Free PMC Article
    5. Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Bowman CE, et al. Mol Cell Biol, 2016 Aug 1. PMID 27215380, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphorylase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorylase kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphorylase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycogen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phosphorylase kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphorylase kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phosphorylase kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphorylase b kinase gamma catalytic chain, liver/testis isoform
    Names
    PHK-gamma-LT
    PHK-gamma-T
    phosphorylase kinase subunit gamma-2
    serine/threonine-protein kinase PHKG2
    NP_001347670.1
    NP_081164.2
    XP_006508230.1
    XP_006508231.1
    XP_006508232.1
    XP_030098816.1
    XP_030098817.1
    XP_030098818.1
    XP_030098819.1
    XP_036009301.1
    XP_036009302.1
    XP_036009303.1
    XP_036009304.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360741.1 → NP_001347670.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction and lacks an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC122417
      Conserved Domains (1) summary
      cl21453
      Location:1 → 182
      PKc_like; Protein Kinases, catalytic domain

    2. NM_026888.3 → NP_081164.2  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform 1

      See identical proteins and their annotated locations for NP_081164.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA198694, AK005277, AK079680, BQ176174
      Consensus CDS
      CCDS21869.1
      UniProtKB/Swiss-Prot
      A6H632, Q9DB30
      Related
      ENSMUSP00000033086.2, ENSMUST00000033086.8
      Conserved Domains (1) summary
      cl21453
      Location:13 → 291
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127169252..127182479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153408.1 → XP_036009301.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1

      UniProtKB/Swiss-Prot
      A6H632, Q9DB30
      Related
      ENSMUSP00000113533.2, ENSMUST00000121004.3
      Conserved Domains (1) summary
      cl21453
      Location:13 → 291
      PKc_like; Protein Kinases, catalytic domain

    2. XM_036153410.1 → XP_036009303.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1 → 189
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006508167.4 → XP_006508230.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1

      See identical proteins and their annotated locations for XP_006508230.1

      UniProtKB/Swiss-Prot
      A6H632, Q9DB30
      Conserved Domains (1) summary
      cl21453
      Location:13 → 291
      PKc_like; Protein Kinases, catalytic domain

    4. XM_030242958.1 → XP_030098818.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1 → 182
      PKc_like; Protein Kinases, catalytic domain

    5. XM_030242957.1 → XP_030098817.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1 → 189
      PKc_like; Protein Kinases, catalytic domain

    6. XM_036153411.1 → XP_036009304.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1 → 189
      PKc_like; Protein Kinases, catalytic domain

    7. XM_006508168.3 → XP_006508231.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X2

      See identical proteins and their annotated locations for XP_006508231.1

      Conserved Domains (1) summary
      cl21453
      Location:10 → 194
      PKc_like; Protein Kinases, catalytic domain

    8. XM_030242956.1 → XP_030098816.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1 → 189
      PKc_like; Protein Kinases, catalytic domain

    9. XM_006508169.4 → XP_006508232.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X2

      See identical proteins and their annotated locations for XP_006508232.1

      Conserved Domains (1) summary
      cl21453
      Location:10 → 194
      PKc_like; Protein Kinases, catalytic domain

    10. XM_036153409.1 → XP_036009302.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:10 → 194
      PKc_like; Protein Kinases, catalytic domain

    11. XM_030242959.1 → XP_030098819.1  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1 → 182
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DB30.2 GenPept UniProtKB/Swiss-Prot:Q9DB30

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