Fbxo6 F-box protein 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxo6provided by MGI
Official Full Name: F-box protein 6provided by MGI
Primary source: MGI:MGI:1354743
See related: Ensembl:ENSMUSG00000055401 AllianceGenome:MGI:1354743
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FBG2; Fbs2; Fbx6b; Fbxo6b
Summary: Enables carbohydrate binding activity. Contributes to ubiquitin protein ligase activity. Involved in ERAD pathway and SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within glycoprotein catabolic process. Located in endoplasmic reticulum quality control compartment. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and lung. Orthologous to human FBXO6 (F-box protein 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 22.6), liver adult (RPKM 18.1) and 28 other tissues See more
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Genomic context

Location:: 4 E2; 4 78.67 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (148230173..148236592, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (148145716..148152135, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis.
Title: Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis.
FBXO6 regulates the antiviral immune responses via mediating alveolar macrophages survival.
Title: FBXO6 regulates the antiviral immune responses via mediating alveolar macrophages survival.
Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase.
Title: Loss of peptide:N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase.
Fbs2 is a novel member of F-box protein family that recognizes N-glycans and plays a role in ERAD
Title: Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124777 (e-PCR)
- UniSTS:161599

AV001623 (e-PCR)
- UniSTS:165368

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to ubiquitin protein ligase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycoprotein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycoprotein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum quality control compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum quality control compartment	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: F-box only protein 6

Names: F-box only protein 6b; F-box protein that recognizes sugar chains 2; F-box/G-domain protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163704.1 → NP_001157176.1 F-box only protein 6

See identical proteins and their annotated locations for NP_001157176.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.

Source sequence(s)

AK150612, AK165867, BB854497

Consensus CDS

CCDS18933.1

UniProtKB/Swiss-Prot

A2A7H0, A2A7H2, B2KFL0, B2KFL2, Q3TML5, Q3UCB0, Q9QZN4

UniProtKB/TrEMBL

Z4YN00

Related

ENSMUSP00000030858.8, ENSMUST00000030858.14

Conserved Domains (2) summary

pfam04300
Location:70 → 248

FBA; F-box associated region

pfam12937
Location:4 → 47

F-box-like
NM_001163705.1 → NP_001157177.1 F-box only protein 6

See identical proteins and their annotated locations for NP_001157177.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.

Source sequence(s)

AK165867, AK171483, BB854497, BY260050

Consensus CDS

CCDS18933.1

UniProtKB/Swiss-Prot

A2A7H0, A2A7H2, B2KFL0, B2KFL2, Q3TML5, Q3UCB0, Q9QZN4

UniProtKB/TrEMBL

Z4YN00

Conserved Domains (2) summary

pfam04300
Location:70 → 248

FBA; F-box associated region

pfam12937
Location:4 → 47

F-box-like
NM_001163706.1 → NP_001157178.1 F-box only protein 6

See identical proteins and their annotated locations for NP_001157178.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.

Source sequence(s)

AK165867, AK171483

Consensus CDS

CCDS18933.1

UniProtKB/Swiss-Prot

A2A7H0, A2A7H2, B2KFL0, B2KFL2, Q3TML5, Q3UCB0, Q9QZN4

UniProtKB/TrEMBL

Z4YN00

Related

ENSMUSP00000062348.6, ENSMUST00000056965.12

Conserved Domains (2) summary

pfam04300
Location:70 → 248

FBA; F-box associated region

pfam12937
Location:4 → 47

F-box-like
NM_001163707.1 → NP_001157179.1 F-box only protein 6

See identical proteins and their annotated locations for NP_001157179.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.

Source sequence(s)

AK165867, AK171483, BY164736

Consensus CDS

CCDS18933.1

UniProtKB/Swiss-Prot

A2A7H0, A2A7H2, B2KFL0, B2KFL2, Q3TML5, Q3UCB0, Q9QZN4

UniProtKB/TrEMBL

Z4YN00

Related

ENSMUSP00000130188.2, ENSMUST00000168503.8

Conserved Domains (2) summary

pfam04300
Location:70 → 248

FBA; F-box associated region

pfam12937
Location:4 → 47

F-box-like
NM_015797.4 → NP_056612.1 F-box only protein 6

See identical proteins and their annotated locations for NP_056612.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-6 encode the same protein.

Source sequence(s)

AK165867, BB854497

Consensus CDS

CCDS18933.1

UniProtKB/Swiss-Prot

A2A7H0, A2A7H2, B2KFL0, B2KFL2, Q3TML5, Q3UCB0, Q9QZN4

UniProtKB/TrEMBL

Z4YN00

Related

ENSMUSP00000101331.2, ENSMUST00000105706.8

Conserved Domains (2) summary

pfam04300
Location:70 → 248

FBA; F-box associated region

pfam12937
Location:4 → 47

F-box-like