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    Ranbp3l RAN binding protein 3-like [ Mus musculus (house mouse) ]

    Gene ID: 223332, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ranbp3lprovided by MGI
    Official Full Name
    RAN binding protein 3-likeprovided by MGI
    Primary source
    MGI:MGI:2444654
    See related
    Ensembl:ENSMUSG00000048424 AllianceGenome:MGI:2444654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C130037N17Rik
    Summary
    Enables SMAD binding activity. Involved in mesenchymal cell differentiation involved in bone development; negative regulation of osteoblast differentiation; and positive regulation of myoblast differentiation. Predicted to be located in nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. Is expressed in meninges. Orthologous to human RANBP3L (RAN binding protein 3 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 3.4), frontal lobe adult (RPKM 1.3) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ranbp3l in Genome Data Viewer
    Location:
    15 A1; 15 3.82 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (8997209..9071355)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (8967949..9067335)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 3 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 53883 Neighboring gene STARR-positive B cell enhancer ABC_E1904 Neighboring gene STARR-seq mESC enhancer starr_37924 Neighboring gene NAD kinase 2, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E3131 Neighboring gene S-phase kinase-associated protein 2 Neighboring gene LMBR1 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_37931 Neighboring gene STARR-seq mESC enhancer starr_37932 Neighboring gene UDP glycosyltransferases 3 family pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype. Chernyakov D, et al. J Exp Clin Cancer Res, 2021 Jul 7. PMID 34233711, Free PMC Article
    2. Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation. Chen F, et al. Mol Cell Biol, 2015 May. PMID 25755279, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype.
      Title: Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype.
    2. Results demonstrate that RanBP3L, as a nuclear exporter for BMP-specific Smads, plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation.
      Title: Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SMAD binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mesenchymal cell differentiation involved in bone development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ran-binding protein 3-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198024.2 → NP_932141.1  ran-binding protein 3-like

      See identical proteins and their annotated locations for NP_932141.1

      Status: VALIDATED

      Source sequence(s)
      AC119167, AK132406, BC058706
      UniProtKB/Swiss-Prot
      Q3V1J9, Q6PDH4
      Related
      ENSMUSP00000154327.3, ENSMUST00000227191.3
      Conserved Domains (1) summary
      cd13180
      Location:316 → 431
      RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      8997209..9071355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159318.1 → XP_036015211.1  ran-binding protein 3-like isoform X1

      Conserved Domains (1) summary
      cd13180
      Location:316 → 431
      RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

    2. XM_036159319.1 → XP_036015212.1  ran-binding protein 3-like isoform X2

      Conserved Domains (1) summary
      cl17171
      Location:316 → 366
      PH-like; Pleckstrin homology-like domain

    3. XM_036159320.1 → XP_036015213.1  ran-binding protein 3-like isoform X3

      UniProtKB/TrEMBL
      A0A2I3BQU7
      Conserved Domains (1) summary
      cd13180
      Location:195 → 310
      RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain

    4. XM_036159321.1 → XP_036015214.1  ran-binding protein 3-like isoform X4

      Conserved Domains (1) summary
      cd13180
      Location:72 → 187
      RanBD_RanBP3; Ran-binding protein 3 Ran-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PDH4.1 GenPept UniProtKB/Swiss-Prot:Q6PDH4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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