U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Marco macrophage receptor with collagenous structure [ Mus musculus (house mouse) ]

    Gene ID: 17167, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Marcoprovided by MGI
    Official Full Name
    macrophage receptor with collagenous structureprovided by MGI
    Primary source
    MGI:MGI:1309998
    See related
    Ensembl:ENSMUSG00000026390 AllianceGenome:MGI:1309998
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly112; Scara2
    Summary
    Predicted to enable amyloid-beta binding activity and cargo receptor activity. Acts upstream of or within apoptotic cell clearance. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of collagen trimer. Predicted to be active in extracellular matrix and extracellular space. Is expressed in spleen. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human MARCO (macrophage receptor with collagenous structure). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E18 (RPKM 27.1), liver E14 (RPKM 17.6) and 4 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Marco in Genome Data Viewer
    Location:
    1 E2.3; 1 52.71 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (120402267..120432753, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (120474538..120505024, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene complement component 1, q subcomponent-like 2 Neighboring gene STARR-seq mESC enhancer starr_02057 Neighboring gene predicted gene, 46154 Neighboring gene STARR-seq mESC enhancer starr_02059 Neighboring gene STARR-seq mESC enhancer starr_02060 Neighboring gene STARR-seq mESC enhancer starr_02061 Neighboring gene STARR-seq mESC enhancer starr_02062 Neighboring gene predicted gene, 41939 Neighboring gene STARR-seq mESC enhancer starr_02064 Neighboring gene engrailed 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages. Gomes IN, et al. Parasite Immunol, 2009 Apr. PMID 19292770
    2. Therapeutic inflammatory monocyte modulation using immune-modifying microparticles. Getts DR, et al. Sci Transl Med, 2014 Jan 15. PMID 24431111, Free PMC Article
    3. Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure. Murthy S, et al. FASEB J, 2015 Aug. PMID 25953850, Free PMC Article
    4. Macrophage Receptor with Collagenous Structure (MARCO) Is Processed by either Macropinocytosis or Endocytosis-Autophagy Pathway. Hirano S, et al. PLoS One, 2015. PMID 26545255, Free PMC Article
    5. Examination of MARCO activity on dendritic cell phenotype and function using a gene knockout mouse. Komine H, et al. PLoS One, 2013. PMID 23840879, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of the scavenger receptor MARCO results in uncontrolled vomocytosis of fungi from macrophages.
      Title: Loss of the scavenger receptor MARCO results in uncontrolled vomocytosis of fungi from macrophages.
    2. TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain.
      Title: TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain.
    3. MARCO(+) lymphatic endothelial cells sequester arthritogenic alphaviruses to limit viremia and viral dissemination.
      Title: MARCO(+) lymphatic endothelial cells sequester arthritogenic alphaviruses to limit viremia and viral dissemination.
    4. Cigarette smoke extract decreased basal and lipopolysaccharide-induced expression of MARCO via degradation of p300.
      Title: Cigarette smoke extract decreased basal and lipopolysaccharide-induced expression of MARCO via degradation of p300.
    5. Scavenger receptor MARCO contributes to cellular internalization of exosomes by dynamin-dependent endocytosis and macropinocytosis.
      Title: Scavenger receptor MARCO contributes to cellular internalization of exosomes by dynamin-dependent endocytosis and macropinocytosis.
    6. The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.
      Title: The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.
    7. Age-dependent effect between MARCO and TLR4 on PMMA particle phagocytosis by macrophages.
      Title: Age-dependent effect between MARCO and TLR4 on PMMA particle phagocytosis by macrophages.
    8. Clearance from the circulation of chikungunya and o'nyong 'nyong virus was independent of natural antibodies or complement factor C3, and instead relied on scavenger receptor SR-A6 (MARCO).
      Title: Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses.
    9. the absence of MARCO does not interfere with the efficiency of HSV-1 entry and that the inhibitory effect on viral adsorption by poly(I), a ligand of MARCO, is independent of MARCO.
      Title: Entry of Herpes Simplex Virus 1 into Epidermis and Dermal Fibroblasts Is Independent of the Scavenger Receptor MARCO.
    10. presence of MARCO allows rapid Adenovirus (AD) gene expression and strong virus-stimulated innate responses; blockage or lack of MARCO results in strong impairment of these processes;. MARCO is involved in innate Ad recognition and the elevated Ad sensitivity of MARCO-expressing macrophages is due to the expression of this receptor on the cell surface
      Title: Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cargo receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cargo receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amyloid-beta clearance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amyloid-beta clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phagocytosis, engulfment IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    macrophage receptor MARCO

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010766.3 → NP_034896.1  macrophage receptor MARCO

      See identical proteins and their annotated locations for NP_034896.1

      Status: VALIDATED

      Source sequence(s)
      AA185896, BC132338
      Consensus CDS
      CCDS15234.1
      UniProtKB/Swiss-Prot
      Q60754
      UniProtKB/TrEMBL
      A2RT24, Q3TF99
      Related
      ENSMUSP00000027639.2, ENSMUST00000027639.8
      Conserved Domains (3) summary
      pfam01391
      Location:150 → 207
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:423 → 518
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:428 → 518
      SRCR; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      120402267..120432753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60754.1 GenPept UniProtKB/Swiss-Prot:Q60754

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous