Chi3l1 chitinase 3 like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chi3l1provided by MGI
Official Full Name: chitinase 3 like 1provided by MGI
Primary source: MGI:MGI:1340899
See related: Ensembl:ENSMUSG00000064246 AllianceGenome:MGI:1340899
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gp39; Brp39; Chil1
Summary: Predicted to enable chitin binding activity. Involved in positive regulation of interleukin-8 production; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of protein phosphorylation. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; limb; liver; and skeleton. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to human CHI3L1 (chitinase 3 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward lung adult (RPKM 398.3) See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 58.15 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (134109894..134117769)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (134182156..134190031)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus.
Title: Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus.
Chitinase 3-Like 1 and C-X-C motif chemokine ligand 5 proteins and the hair cycle.
Title: Chitinase 3-Like 1 and C-X-C motif chemokine ligand 5 proteins and the hair cycle.
BRP39 Regulates Neutrophil Recruitment in NLRP3 Inflammasome-Induced Liver Inflammation.
Title: BRP39 Regulates Neutrophil Recruitment in NLRP3 Inflammasome-Induced Liver Inflammation.
IL13Ralpha2 as a crucial receptor for Chi3l1 in osteoclast differentiation and bone resorption through the MAPK/AKT pathway.
Title: IL13Rα2 as a crucial receptor for Chi3l1 in osteoclast differentiation and bone resorption through the MAPK/AKT pathway.
An Association of Chitinase-3 Like-Protein-1 With Neuronal Deterioration in Multiple Sclerosis.
Title: An Association of Chitinase-3 Like-Protein-1 With Neuronal Deterioration in Multiple Sclerosis.
The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer.
Title: The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer.
Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Abeta burden and restores memory functions in 5xFAD mice.
Title: Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice.
EGR1 mediates METTL3/m[6]A/CHI3L1 to promote osteoclastogenesis in osteoporosis.
Title: EGR1 mediates METTL3/m(6)A/CHI3L1 to promote osteoclastogenesis in osteoporosis.
E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1.
Title: E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1.
Chitinase-3-like 1 regulates TH2 cells, TFH cells and IgE responses to helminth infection.
Title: Chitinase-3-like 1 regulates T(H)2 cells, T(FH) cells and IgE responses to helminth infection.

Submit: New GeneRIF Correction See all GeneRIFs (64)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chitin binding	ISO Inferred from Sequence Orthology more info
enables chitin binding	ISS Inferred from Sequence or Structural Similarity more info
NOT enables chitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of NF-kappaB-inducing kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	ISS Inferred from Sequence or Structural Similarity more info
involved_in chitin catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung development	ISO Inferred from Sequence Orthology more info
involved_in lung development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-8 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-1	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to interleukin-6	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to mechanical stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to tumor necrosis factor	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: chitinase-3-like protein 1

Names: CGP-39; GP-39; YKL-40; breast regression protein 39; cartilage glycoprotein 39; chitinase-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374626.1 → NP_001361555.1 chitinase-3-like protein 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC137104

Consensus CDS

CCDS87878.1

Related

ENSMUSP00000119205.2, ENSMUST00000156873.8

Conserved Domains (1) summary

cd02872
Location:22 → 378

GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
NM_007695.4 → NP_031721.2 chitinase-3-like protein 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_031721.2

Status: VALIDATED

Source sequence(s)

AC137104

Consensus CDS

CCDS48368.1

UniProtKB/Swiss-Prot

B0FEU7, D3Z2P2, Q3U291, Q4FJW9, Q61362, Q8BKL8, Q99J84

Related

ENSMUSP00000080717.4, ENSMUST00000082060.10

Conserved Domains (1) summary

cd02872
Location:32 → 388

GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...