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    Bend6 BEN domain containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 320705, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Bend6provided by MGI
    Official Full Name
    BEN domain containing 6provided by MGI
    Primary source
    MGI:MGI:2444572
    See related
    Ensembl:ENSMUSG00000042182 AllianceGenome:MGI:2444572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230209C24Rik
    Summary
    Enables chromatin binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of Notch signaling pathway and positive regulation of neuron differentiation. Located in nucleus. Is expressed in telencephalon. Orthologous to human BEND6 (BEN domain containing 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 60.3), cortex adult (RPKM 30.9) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bend6 in Genome Data Viewer
    Location:
    1 B; 1 12.85 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (33891133..33946925, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (33852052..33907933, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00543 Neighboring gene zinc finger protein 451 Neighboring gene predicted gene 15455 Neighboring gene STARR-positive B cell enhancer ABC_E7716 Neighboring gene predicted gene, 38471 Neighboring gene STARR-seq mESC enhancer starr_00549 Neighboring gene dystonin Neighboring gene STARR-seq mESC enhancer starr_00551 Neighboring gene predicted gene, 53546 Neighboring gene predicted gene, 23792 Neighboring gene STARR-seq mESC enhancer starr_00553 Neighboring gene STARR-seq mESC enhancer starr_00560 Neighboring gene STARR-seq mESC enhancer starr_00563 Neighboring gene STARR-seq mESC enhancer starr_00567 Neighboring gene microRNA 6896

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family. Dai Q, et al. Genes Dev, 2015 Jan 1. PMID 25561495, Free PMC Article
    2. BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. Dai Q, et al. Development, 2013 May. PMID 23571214, Free PMC Article
    3. Regulation of embryonic and adult neurogenesis by Ars2. Yu Y, et al. Development, 2020 Jan 22. PMID 31969356, Free PMC Article
    4. Transcriptional programs in transient embryonic zones of the cerebral cortex defined by high-resolution mRNA sequencing. Ayoub AE, et al. Proc Natl Acad Sci U S A, 2011 Sep 6. PMID 21873192, Free PMC Article
    5. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BEND6 knock down increases neural stem cell self-renewal in neocortex.
      Title: BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BEN domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310484.1 → NP_001297413.1  BEN domain-containing protein 6 isoform 2

      See identical proteins and their annotated locations for NP_001297413.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate 5' exon compared to variant 1, which results in translation initiation at a downstream AUG. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK044633, BC057378
      Consensus CDS
      CCDS78557.1
      UniProtKB/Swiss-Prot
      Q6PFX2
      Related
      ENSMUSP00000110814.2, ENSMUST00000115161.8
      Conserved Domains (1) summary
      smart01025
      Location:128 → 209
      BEN; The BEN domain is found in diverse animal proteins

    2. NM_177235.3 → NP_796209.2  BEN domain-containing protein 6 isoform 1

      See identical proteins and their annotated locations for NP_796209.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC057378
      Consensus CDS
      CCDS35533.1
      UniProtKB/Swiss-Prot
      Q6PFX2, Q8BLC9, Q8BXN2
      Related
      ENSMUSP00000052919.9, ENSMUST00000062289.11
      Conserved Domains (1) summary
      smart01025
      Location:190 → 271
      BEN; The BEN domain is found in diverse animal proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      33891133..33946925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321224.3 → XP_017176713.1  BEN domain-containing protein 6 isoform X1

      Conserved Domains (1) summary
      PRK00252
      Location:66 → 102
      alaS; alanyl-tRNA synthetase; Reviewed
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PFX2.1 GenPept UniProtKB/Swiss-Prot:Q6PFX2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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