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    Haao 3-hydroxyanthranilate 3,4-dioxygenase [ Mus musculus (house mouse) ]

    Gene ID: 107766, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Haaoprovided by MGI
    Official Full Name
    3-hydroxyanthranilate 3,4-dioxygenaseprovided by MGI
    Primary source
    MGI:MGI:1349444
    See related
    Ensembl:ENSMUSG00000000673 AllianceGenome:MGI:1349444
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3HAO; 3-HAO; 3-HAOxase; 0610007K21Rik; 0610012J07Rik
    Summary
    Enables 3-hydroxyanthranilate 3,4-dioxygenase activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; response to cadmium ion; and response to zinc ion. Predicted to be located in cytosol and mitochondrial membrane. Predicted to be active in cytoplasm. Is expressed in ductus deferens; epididymis; esophagus; metanephros; and testis. Orthologous to human HAAO (3-hydroxyanthranilate 3,4-dioxygenase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 126.1), kidney adult (RPKM 31.2) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Haao in Genome Data Viewer
    Location:
    17 E4; 17 54.85 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (84138777..84157589, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (83831348..83848981, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene metastasis associated 3 Neighboring gene predicted gene, 46597 Neighboring gene STARR-seq mESC enhancer starr_43408 Neighboring gene predicted gene, 41637 Neighboring gene STARR-positive B cell enhancer ABC_E1202 Neighboring gene RIKEN cDNA C430042M11 gene Neighboring gene chaperonin containing Tcp1, subunit 7 (eta) pseudogene Neighboring gene nuclear encoded tRNA isoleucine 17 (anticodon TAT)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NAD deficiency due to environmental factors or gene-environment interactions causes congenital malformations and miscarriage in mice. Cuny H, et al. Proc Natl Acad Sci U S A, 2020 Feb 18. PMID 32015132, Free PMC Article
    2. High levels of quinolinic acid in brain of epilepsy-prone E1 mice. Nakano K, et al. Brain Res, 1993 Aug 13. PMID 8374778
    3. Abnormally high activity of 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice. Nakano K, et al. Brain Res, 1992 Feb 14. PMID 1611505
    4. Differential expression of the astrocytic enzymes 3-hydroxyanthranilic acid oxygenase, kynurenine aminotransferase and glutamine synthetase in seizure-prone and non-epileptic mice. Eastman CL, et al. Epilepsy Res, 1994 Jul. PMID 7805640
    5. Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation. Parrott JM, et al. Transl Psychiatry, 2016 Oct 18. PMID 27754481, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-hydroxyanthranilate 3,4-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxyanthranilate 3,4-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-hydroxyanthranilate 3,4-dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ferrous iron binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxygen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' NAD biosynthetic process from tryptophan IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in NAD biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in anthranilate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron cellular homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in quinolinate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in quinolinate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in quinolinate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in quinolinate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to zinc ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to zinc ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tryptophan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    3-hydroxyanthranilate 3,4-dioxygenase
    Names
    3-hydroxyanthranilate oxygenase
    3-hydroxyanthranilic acid dioxygenase
    HAD
    NP_079601.1
    XP_006523526.1
    XP_006523528.1
    XP_030105301.1
    XP_030105302.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025325.2 → NP_079601.1  3-hydroxyanthranilate 3,4-dioxygenase

      See identical proteins and their annotated locations for NP_079601.1

      Status: PROVISIONAL

      Source sequence(s)
      BC094021
      Consensus CDS
      CCDS37709.1
      UniProtKB/Swiss-Prot
      Q52L88, Q78JT3
      Related
      ENSMUSP00000000687.8, ENSMUST00000000687.9
      Conserved Domains (2) summary
      cd06123
      Location:10 → 159
      cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain
      cl40423
      Location:209 → 260
      cupin_RmlC-like; RmlC-like cupin superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      84138777..84157589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523463.5 → XP_006523526.1  3-hydroxyanthranilate 3,4-dioxygenase isoform X1

      See identical proteins and their annotated locations for XP_006523526.1

      UniProtKB/Swiss-Prot
      Q52L88, Q78JT3
      Conserved Domains (2) summary
      cd06123
      Location:10 → 159
      cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain
      cl40423
      Location:209 → 260
      cupin_RmlC-like; RmlC-like cupin superfamily

    2. XM_030249442.2 → XP_030105302.1  3-hydroxyanthranilate 3,4-dioxygenase isoform X3

      Conserved Domains (2) summary
      cd06123
      Location:1 → 98
      cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain
      cl40423
      Location:148 → 199
      cupin_RmlC-like; RmlC-like cupin superfamily

    3. XM_006523465.5 → XP_006523528.1  3-hydroxyanthranilate 3,4-dioxygenase isoform X2

      Conserved Domains (2) summary
      cd06123
      Location:1 → 125
      cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain
      cl40423
      Location:175 → 226
      cupin_RmlC-like; RmlC-like cupin superfamily

    4. XM_030249441.2 → XP_030105301.1  3-hydroxyanthranilate 3,4-dioxygenase isoform X1

      UniProtKB/Swiss-Prot
      Q52L88, Q78JT3
      Conserved Domains (2) summary
      cd06123
      Location:10 → 159
      cupin_HAO; 3-Hydroxyanthranilate-3,4-dioxygenase, cupin domain
      cl40423
      Location:209 → 260
      cupin_RmlC-like; RmlC-like cupin superfamily

    RNA

    1. XR_385257.5 RNA Sequence

    2. XR_004939459.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q78JT3.1 GenPept UniProtKB/Swiss-Prot:Q78JT3

    Gene LinkOut

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