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    Efna3 ephrin A3 [ Mus musculus (house mouse) ]

    Gene ID: 13638, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Efna3provided by MGI
    Official Full Name
    ephrin A3provided by MGI
    Primary source
    MGI:MGI:106644
    See related
    Ensembl:ENSMUSG00000028039 AllianceGenome:MGI:106644
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Epl3; EFL-2; Ehk1-L; LERK-3
    Summary
    Enables ephrin receptor binding activity. Involved in ephrin receptor signaling pathway. Predicted to be located in side of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human EFNA3 (ephrin A3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 18.6), cortex adult (RPKM 12.4) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Efna3 in Genome Data Viewer
    Location:
    3 F1; 3 39.06 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89221200..89231359, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89313899..89322939, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ephrin A1 Neighboring gene VISTA enhancer mm1415 Neighboring gene predicted gene, 33845 Neighboring gene predicted gene, 34014 Neighboring gene predicted gene 15998 Neighboring gene STARR-seq mESC enhancer starr_08230 Neighboring gene predicted gene, 34118 Neighboring gene ephrin A4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ephrin-A3 suppresses Wnt signaling to control retinal stem cell potency. Fang Y, et al. Stem Cells, 2013 Feb. PMID 23165658, Free PMC Article
    2. Ephrin-A3 not only increases the density of hair follicles but also accelerates anagen development in neonatal mice. Yamada Y, et al. J Dermatol Sci, 2008 Dec. PMID 18640011
    3. Heparan sulfate regulates ephrin-A3/EphA receptor signaling. Irie F, et al. Proc Natl Acad Sci U S A, 2008 Aug 26. PMID 18715996, Free PMC Article
    4. Normal muscle fiber type distribution is recapitulated in aged ephrin-A3(-/-) mice that previously lacked most slow myofibers. Arpke RW, et al. Am J Physiol Cell Physiol, 2023 Mar 1. PMID 36717102, Free PMC Article
    5. Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders. Wurzman R, et al. Behav Brain Res, 2015 Feb 1. PMID 25281279, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcriptional regulation of the mouse EphA4, Ephrin-B2 and Ephrin-A3 genes by the circadian clock machinery.
      Title: Transcriptional regulation of the mouse EphA4, Ephrin-B2 and Ephrin-A3 genes by the circadian clock machinery.
    2. Ephrin-A3 is required for tonotopic map precision and auditory functions in the mouse auditory brainstem.
      Title: Ephrin-A3 is required for tonotopic map precision and auditory functions in the mouse auditory brainstem.
    3. Findings suggest a putative novel mechanism for desipramine to modulate long-term potentiation through the regulation of the ephrinA3/EphA4 signaling pathway
      Title: Desipramine targets astrocytes to attenuate synaptic plasticity via modulation of the ephrinA3/EphA4 signalling.
    4. The ephrin-A2/-A3 DKO mice have utility as a novel ASD model with an emphasis on sensory abnormalities and restricted, repetitive behavioral symptoms.
      Title: Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders.
    5. Ephrin-A2 and -A3 are negative regulators of the proliferative and neurogenic potentials of Muller cells.
      Title: Ephrin-A2 and -A3 are negative regulators of the regenerative potential of Möller cells.
    6. Ephrin-A3 suppresses Wnt signaling to control retinal stem cell potency.
      Title: Ephrin-A3 suppresses Wnt signaling to control retinal stem cell potency.
    7. Downregulation of the EphA4 receptor via siRNA transfection reduced the repulsive effect of ephrin-A3, indicating that EphA4 mediates at least in part the repulsive effect of ephrin-A3.
      Title: Ephrins guide migrating cortical interneurons in the basal telencephalon.
    8. Data show that a number of Eph receptors and ephrins were expressed in hematopoietic stem cells.
      Title: Activation of ephrin A proteins influences hematopoietic stem cell adhesion and trafficking patterns.
    9. These results suggest that EphA4/ephrin-A3 signaling is a critical mechanism for astrocytes to regulate synaptic function and plasticity.
      Title: Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport.
    10. Results suggest that the interaction between neuronal EphA4 and glial ephrin-A3 bidirectionally controls synapse morphology and glial glutamate transport, ultimately regulating hippocampal function.
      Title: Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129300, MGC129301

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ephrin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ephrin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ephrin-A3
    Names
    EHK1 ligand
    EPH-related receptor tyrosine kinase ligand 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377116.1 → NP_001364045.1  ephrin-A3 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC132327, AC171273
      UniProtKB/TrEMBL
      A0A0G2JGE9
      Related
      ENSMUSP00000143539.2, ENSMUST00000200436.2
      Conserved Domains (1) summary
      cd10425
      Location:31 → 158
      Ephrin-A_Ectodomain; Ectodomain of Ephrin A

    2. NM_001377117.1 → NP_001364046.1  ephrin-A3 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform c.
      Source sequence(s)
      AC132327, AC171273
      Conserved Domains (1) summary
      cl19115
      Location:1 → 77
      Cupredoxin; Cupredoxin superfamily

    3. NM_001377118.1 → NP_001364047.1  ephrin-A3 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform c.
      Source sequence(s)
      AC132327, AC171273
      Conserved Domains (1) summary
      cl19115
      Location:1 → 77
      Cupredoxin; Cupredoxin superfamily

    4. NM_001377119.1 → NP_001364048.1  ephrin-A3 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform c.
      Source sequence(s)
      AC132327, AC171273
      Conserved Domains (1) summary
      cl19115
      Location:1 → 77
      Cupredoxin; Cupredoxin superfamily

    5. NM_001377120.1 → NP_001364049.1  ephrin-A3 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 7, encodes isoform d.
      Source sequence(s)
      AC132327, AC171273
      Conserved Domains (1) summary
      cl19115
      Location:1 → 77
      Cupredoxin; Cupredoxin superfamily

    6. NM_001377121.1 → NP_001364050.1  ephrin-A3 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 6, encodes isoform d.
      Source sequence(s)
      AC132327, AC171273
      Conserved Domains (1) summary
      cl19115
      Location:1 → 77
      Cupredoxin; Cupredoxin superfamily

    7. NM_010108.2 → NP_034238.1  ephrin-A3 isoform a precursor

      See identical proteins and their annotated locations for NP_034238.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC132327, AC171273
      Consensus CDS
      CCDS38488.1
      UniProtKB/Swiss-Prot
      O08545, O55217, Q08AV0
      Related
      ENSMUSP00000029673.6, ENSMUST00000029673.10
      Conserved Domains (1) summary
      cd10425
      Location:31 → 158
      Ephrin-A_Ectodomain; Ectodomain of Ephrin A

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89221200..89231359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162885.1 → XP_036018778.1  ephrin-A3 isoform X1

      Conserved Domains (1) summary
      cl19115
      Location:1 → 77
      Cupredoxin; Cupredoxin superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08545.4 GenPept UniProtKB/Swiss-Prot:O08545

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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