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    Cep104 centrosomal protein 104 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246295, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Cep104provided by RGD
    Official Full Name
    centrosomal protein 104provided by RGD
    Primary source
    RGD:708505
    See related
    EnsemblRapid:ENSRNOG00000025000 AllianceGenome:RGD:708505
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GlyBP
    Summary
    Enables glutamate binding activity; glycine binding activity; and thienylcyclohexylpiperidine binding activity. Predicted to be located in centriole. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in Joubert syndrome 25 and autosomal recessive intellectual developmental disorder 77. Orthologous to human CEP104 (centrosomal protein 104). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Kidney (RPKM 113.5), Adrenal (RPKM 79.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep104 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (169817383..169849681)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (164534773..164567260)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (171262278..171294560)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 1 open reading frame 174 Neighboring gene DNA fragmentation factor subunit beta Neighboring gene leucine rich repeat containing 47 Neighboring gene uncharacterized LOC120103048 Neighboring gene small integral membrane protein 1 (Vel blood group) Neighboring gene coiled-coil domain containing 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding protein: isolation and immunochemical characterization. Babcock KK, et al. Neurochem Int, 1996 Nov. PMID 8939461
    2. Cloning of the cDNA for a brain glycine-, glutamate- and thienylcyclohexylpiperidine-binding protein. Kumar KN, et al. Biochem Biophys Res Commun, 1995 Nov 2. PMID 7488117
    3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutamate binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycine binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables thienylcyclohexylpiperidine binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 104 kDa
    Names
    gly-, L-Glu and TCP-binding protein
    glycine-, glutamate- and thienylcyclohexylpiperidine-binding protein
    glycine-, glutamate-, thienylcyclohexylpiperidine-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145082.2 → NP_659550.2  centrosomal protein of 104 kDa

      Status: VALIDATED

      Source sequence(s)
      AA924538, BI289406, CB544954, CB792008, CK843167, CO390283, CV797293, DV722335, FM108776, JAXUCZ010000005, U53513
      UniProtKB/Swiss-Prot
      A0A0G2JUH6, D3Z8X7, Q62965
      Related
      ENSRNOP00000034972.6, ENSRNOT00000031138.7
      Conserved Domains (2) summary
      PHA03247
      Location:300 → 418
      PHA03247; large tegument protein UL36; Provisional
      sd00044
      Location:431 → 468
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      169817383..169849681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109277.2 → XP_038965205.1  centrosomal protein of 104 kDa isoform X2

      UniProtKB/Swiss-Prot
      A0A0G2JUH6, D3Z8X7, Q62965
      UniProtKB/TrEMBL
      A0A1P0QEF5
      Related
      ENSRNOP00000069101.2, ENSRNOT00000077307.3
      Conserved Domains (2) summary
      PHA03247
      Location:300 → 418
      PHA03247; large tegument protein UL36; Provisional
      sd00044
      Location:431 → 468
      HEAT; HEAT repeat [structural motif]

    2. XM_039109278.2 → XP_038965206.1  centrosomal protein of 104 kDa isoform X3

      UniProtKB/Swiss-Prot
      A0A0G2JUH6, D3Z8X7, Q62965
      Related
      ENSRNOP00000077236.2, ENSRNOT00000108344.2
      Conserved Domains (2) summary
      PHA03247
      Location:300 → 418
      PHA03247; large tegument protein UL36; Provisional
      sd00044
      Location:431 → 468
      HEAT; HEAT repeat [structural motif]

    3. XM_039109276.2 → XP_038965204.1  centrosomal protein of 104 kDa isoform X1

      UniProtKB/Swiss-Prot
      A0A0G2JUH6, D3Z8X7, Q62965
      UniProtKB/TrEMBL
      A0A8L2QJT0
      Conserved Domains (2) summary
      PHA03247
      Location:300 → 418
      PHA03247; large tegument protein UL36; Provisional
      sd00044
      Location:431 → 468
      HEAT; HEAT repeat [structural motif]

    4. XM_039109279.2 → XP_038965207.1  centrosomal protein of 104 kDa isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y1C2
      Related
      ENSRNOP00000077901.2, ENSRNOT00000109206.2
      Conserved Domains (2) summary
      PHA03247
      Location:251 → 369
      PHA03247; large tegument protein UL36; Provisional
      sd00044
      Location:382 → 419
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3Z8X7.3 GenPept UniProtKB/Swiss-Prot:D3Z8X7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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