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    Sult2a1 sulfotransferase family 2A member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24912, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Sult2a1provided by RGD
    Official Full Name
    sulfotransferase family 2A member 1provided by RGD
    Primary source
    RGD:621337
    See related
    EnsemblRapid:ENSRNOG00000078002 AllianceGenome:RGD:621337
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    STa; St2; Sth2; Smp-2; St2a1
    Summary
    Enables 3'-phosphoadenosine 5'-phosphosulfate binding activity and alcohol sulfotransferase activity. Involved in several processes, including cellular response to vitamin D; response to activity; and sulfation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human SULT2A1 (sulfotransferase family 2A member 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Restricted expression toward (RPKM 6959.5) See more
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    Genomic context

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    See Sult2a1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (84582011..84639001, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (75451178..75508113, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (76558721..76614315, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene nucleolin, pseudogene 3 Neighboring gene alcohol sulfotransferase-like Neighboring gene U6 spliceosomal RNA Neighboring gene signal recognition particle 72, pseudogene 1 Neighboring gene nucleolin, pseudogene 2 Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA glycine (anticodon ACC) 2 Neighboring gene sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Androgen metabolism and JAK/STAT pathway genes and prostate cancer risk. Kwon EM, et al. Cancer Epidemiol, 2012 Aug. PMID 22542949, Free PMC Article
    2. Changes in hepatic androgen sensitivity and gene expression during aging. Chatterjee B, et al. J Steroid Biochem Mol Biol, 1990 Nov 20. PMID 2257247
    3. Calorie restriction delays age-dependent loss in androgen responsiveness of the rat liver. Chatterjee B, et al. FASEB J, 1989 Feb. PMID 2464518
    4. Molecular cloning and characterization of cDNA for androgen-repressible rat liver protein, SMP-2. Chatterjee B, et al. J Biol Chem, 1987 Jan 15. PMID 3805009
    5. Formation of tamoxifen-DNA adducts via O-sulfonation, not O-acetylation, of alpha-hydroxytamoxifen in rat and human livers. Kim SY, et al. Drug Metab Dispos, 2005 Nov. PMID 16099924

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that the physiological functions of SULT2A1 in different brain regions can be affected by methamphetamine.
      Title: Methamphetamine regulation of sulfotransferase 1A1 and 2A1 expression in rat brain sections.
    2. Data suggest that Sult2a1 and Sult1a1 can be induced in small intestinal mucosa by dietary factors (here, by various levels of caffeine); induction is gender specific and organ specific. Consumption of caffeine may enhance xenobiotic detoxification.
      Title: Caffeine induction of sulfotransferases in rat liver and intestine.
    3. there is a stress regulation mechanism of SULT2A1 at the gene transcription level, possibly occurring via hormones
      Title: Stress regulation of sulfotransferases in male rat liver.
    4. the SULT2A1 gene is mediated by SF1 and indirectly regulated by T(3)
      Title: Indirect regulation of human dehydroepiandrosterone sulfotransferase family 1A member 2 by thyroid hormones.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-phosphoadenosine 5'-phosphosulfate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3'-phosphoadenosine 5'-phosphosulfate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alcohol sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables bile-salt sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to vitamin D IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ethanol catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to activity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to insecticide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in steroid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within sulfation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sulfotransferase 2A1
    Names
    ST
    ST-20
    alcohol sulfotransferase
    bile salt sulfotransferase
    bile-salt sulfotransferase 2A1
    hydroxysteroid sulfotransferase a
    hydroxysteroid sulfotransferase-like
    sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
    sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA) -preferring, member 1
    sulfotransferase hydroxysteroid gene 2
    sulfotransferase, hydroxysteroid preferring 2
    NP_571978.1
    XP_063137138.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131903.1 → NP_571978.1  sulfotransferase 2A1

      See identical proteins and their annotated locations for NP_571978.1

      Status: PROVISIONAL

      Source sequence(s)
      D14987
      UniProtKB/TrEMBL
      A0A8L2R491
      Related
      ENSRNOP00000070596.2, ENSRNOT00000089371.3
      Conserved Domains (1) summary
      pfam00685
      Location:33 → 277
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      84582011..84639001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281068.1 → XP_063137138.1  sulfotransferase 2A1 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_133616.1: Suppressed sequence

      Description
      NM_133616.1: This RefSeq was permanently suppressed because it was based on a sequence from a different organism.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15709.4 GenPept UniProtKB/Swiss-Prot:P15709

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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