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    Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29747, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Kcnmb1provided by RGD
    Official Full Name
    potassium calcium-activated channel subfamily M regulatory beta subunit 1provided by RGD
    Primary source
    RGD:2961
    See related
    EnsemblRapid:ENSRNOG00000005465 AllianceGenome:RGD:2961
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BKbeta; BKbeta1; slo-beta; slo-beta-1; k(VCA)beta-1
    Summary
    Enables potassium channel regulator activity. Involved in several processes, including cellular response to bile acid; cellular response to ethanol; and cellular response to hypoxia. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Used to study hypertension. Biomarker of hypertension and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Uterus (RPKM 45.2), Kidney (RPKM 10.4) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcnmb1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (19062014..19119005)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (18557510..18614824)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (18910586..18922856)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel interacting protein 1 Neighboring gene large ribosomal subunit protein eL29-like Neighboring gene uncharacterized LOC120095245 Neighboring gene uncharacterized LOC134480773 Neighboring gene lymphocyte cytosolic protein 2 Neighboring gene similar to human chromosome 5 open reading frame 58

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. BKbeta1 subunits contribute to BK channel diversity in rat hypothalamic neurons. Salzmann M, et al. Cell Mol Neurobiol, 2010 Aug. PMID 20443052
    2. Differential expression of the alpha and beta subunits of the large-conductance calcium-activated potassium channel: implication for channel diversity. Chang CP, et al. Brain Res Mol Brain Res, 1997 Apr. PMID 9105668
    3. Developmental regulation of the A-type potassium-channel current in hippocampal neurons: role of the Kvbeta 1.1 subunit. Falk T, et al. Neuroscience, 2003. PMID 12890510
    4. Downregulation of the BK channel beta1 subunit in genetic hypertension. Amberg GC, et al. Circ Res, 2003 Nov 14. PMID 14551242
    5. PKC activates BKCa channels in rat pulmonary arterial smooth muscle via cGMP-dependent protein kinase. Barman SA, et al. Am J Physiol Lung Cell Mol Physiol, 2004 Jun. PMID 14966080

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interspecies and regional variability of alcohol action on large cerebral arteries: regulation by KCNMB1 proteins.
      Title: Interspecies and regional variability of alcohol action on large cerebral arteries: regulation by KCNMB1 proteins.
    2. Cholesterol activates BK channels by increasing KCNMB1 protein levels in the plasmalemma.
      Title: Cholesterol activates BK channels by increasing KCNMB1 protein levels in the plasmalemma.
    3. Aging influences cerebrovascular myogenic reactivity and BK channel function in a sex-specific manner.
      Title: Aging influences cerebrovascular myogenic reactivity and BK channel function in a sex-specific manner.
    4. Antenatal Dexamethasone Exposure Impairs the High-Conductance Ca(2+)-Activated K(+) Channels via Epigenetic Alteration at Gene Promoter in Male Offspring.
      Title: Antenatal Dexamethasone Exposure Impairs the High-Conductance Ca(2+)-Activated K(+) Channels via Epigenetic Alteration at Gene Promoter in Male Offspring.
    5. Data show that potassium channel subfamily M regulatory beta subunit 1 (beta1 Subunit) surface trafficking is Impaired in cerebral arteries of stroke-prone spontaneously hypertensive rats (SP-SHRs).
      Title: Impaired Trafficking of β1 Subunits Inhibits BK Channels in Cerebral Arteries of Hypertensive Rats.
    6. hypertension and aging exert opposing effects on DNA methylation at BKbeta1 promoter, subsequently resulting in different beta1 expression
      Title: BK(Ca) channel activity and vascular contractility alterations with hypertension and aging via β1 subunit promoter methylation in mesenteric arteries.
    7. Study showed that in human and rat arterial myocytes, membrane depolarization rapidly increased the cell surface abundance of auxiliary BK beta1 subunits but not that of the pore-forming BKalpha channels. Membrane depolarization stimulated voltage-dependent Ca(2+) channels, leading to Ca(2+) influx and the activation of Rho kinase (ROCK) 1 and 2.
      Title: Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction.
    8. n-3 PUFAs protect the coronary BK channel function and coronary vasoreactivity in diabetic rats as a result of not only increasing BK-beta1 protein expressions, but also decreasing coronary artery tension and coronary smooth muscle cytosolic Ca2+ concentrations.
      Title: Regulation of Coronary Arterial Large Conductance Ca2+-Activated K+ Channel Protein Expression and Function by n-3 Polyunsaturated Fatty Acids in Diabetic Rats.
    9. Data show that leukotriene B4, but not other leukotrienes of the LT4 family, activates recombinant (cbv1-beta1) Lrge-conductance calcium-activated potassium (BK) channels.
      Title: Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4.
    10. aging decreases capability of MaxiK channel in regulating vascular tone in the MA, which may be partially mediated by unparallel downregulation of alpha- and beta1-subunit expression
      Title: Aging decreases the contribution of MaxiK channel in regulating vascular tone in mesenteric artery by unparallel downregulation of α- and β1-subunit expression.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to bile acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to ethanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in detection of calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to calcium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vasodilation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium-activated potassium channel subunit beta-1
    Names
    BK channel subunit beta-1
    calcium-activated potassium channel beta subunit
    calcium-activated potassium channel subunit beta
    calcium-activated potassium channel, subfamily M subunit beta-1
    charybdotoxin receptor subunit beta-1
    maxi K channel subunit beta-1
    potassium channel subfamily M regulatory beta subunit 1
    potassium large conductance calcium-activated channel, subfamily M, beta member 1
    slowpoke-beta

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019273.1 → NP_062146.1  calcium-activated potassium channel subunit beta-1

      See identical proteins and their annotated locations for NP_062146.1

      Status: PROVISIONAL

      Source sequence(s)
      AF020712
      UniProtKB/Swiss-Prot
      O35337, O88805, P97678, Q9ESK7, Q9QWI7
      UniProtKB/TrEMBL
      A6HDH5, B5U130
      Related
      ENSRNOP00000103628.1, ENSRNOT00000159821.1
      Conserved Domains (1) summary
      pfam03185
      Location:7 → 190
      CaKB; Calcium-activated potassium channel, beta subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      19062014..19119005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085796.2 → XP_038941724.1  calcium-activated potassium channel subunit beta-1 isoform X2

      Conserved Domains (1) summary
      pfam03185
      Location:7 → 102
      CaKB; Calcium-activated potassium channel, beta subunit

    2. XM_039085797.2 → XP_038941725.1  calcium-activated potassium channel subunit beta-1 isoform X3

      UniProtKB/TrEMBL
      A6HDH4
      Related
      ENSRNOP00000071161.2, ENSRNOT00000090659.3
      Conserved Domains (1) summary
      pfam03185
      Location:7 → 126
      CaKB; Calcium-activated potassium channel, beta subunit

    3. XM_006246089.5 → XP_006246151.1  calcium-activated potassium channel subunit beta-1 isoform X1

      See identical proteins and their annotated locations for XP_006246151.1

      UniProtKB/Swiss-Prot
      O35337, O88805, P97678, Q9ESK7, Q9QWI7
      UniProtKB/TrEMBL
      A6HDH5, B5U130
      Conserved Domains (1) summary
      pfam03185
      Location:7 → 190
      CaKB; Calcium-activated potassium channel, beta subunit

    4. XM_063268844.1 → XP_063124914.1  calcium-activated potassium channel subunit beta-1 isoform X3

      UniProtKB/TrEMBL
      A6HDH4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97678.4 GenPept UniProtKB/Swiss-Prot:P97678

    Gene LinkOut

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